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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins11 (39.29 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)86 (22.75 %)
The number (and %) of affected PPIs28 (32.56 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI4.571
Assortativity coefficient-0.4576
The network average Clustering coefficient0.556
The number (and %) of a zero Clustering coefficients6 (21.43 %)
The number (and %) of a zero Betweenness Centrality12 (42.86 %)


List of the fusions

PPI for parental proteins: ZNF451 All fusions
: AA489269;
Proteins found in more fusions PIAS1 (see 2 fusions); KDM1A (see 2 fusions); LZTR1 (see 2 fusions); PRPF40A (see 2 fusions); CREB1 (see 2 fusions); ZNF451 (see 1 fusions); SUV39H1 (see 1 fusions); RNF40 (see 2 fusions); UBC (see 1 fusions); PIAS2 (see 2 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ZNF451parental protein280.105556.400zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
2 ARoncoprotein70.6005.333Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 CALCOCO2interactor40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
4 CDC5Linteractor40.6670.667OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
5 CDCA4interactor31.0000SERTA (PF06031, IPR009263): SERTA motif
6 CPTPinteractor100GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP)
7 CREB1oncoprotein50.8330.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
8 FAM118Ainteractor200SIR2_2 (PF13289): SIR2-like domain
9 FXR2interactor40.6671.000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
10 HTTprotein found in more fusions50.8330.500HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
11 JMJD6interactor31.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12 KDM1Aprotein found in more fusions70.4677.667Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
13 LZTR1oncoprotein200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
14 MPP5interactor100L27 (PF02828, IPR014775, SM00569): L27 domain
L27_N (PF09060, IPR015145): L27_N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
15 PCBD1interactor31.0000Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
16 PIAS1suppressor100.52811.733Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
17 PIAS2protein found in more fusions70.8001.400SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
18 PIK3R3interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
19 PRMT1interactor40.6671.000Methyltransf_25 (PF13649): Methyltransferase domain
20 PRMT8interactor31.0000PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
21 PRPF40Aprotein found in more fusions60.7002.167FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
22 RAP1GDS1oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
23 RNF40protein found in more fusions41.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
24 SUMO1interactor70.5335.667Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
25 SUMO2interactor70.6004.333Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
26 SUV39H1protein found in more fusions41.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
27 UBCprotein found in more fusions50.5002.400ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 UBE2Iinteractor120.40026.233UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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