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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZMYND11 (from a repository: Sun Dec 4 10:55:10 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins16 (30.77 %)
The number (and %) of the tumor suppressors12 (23.08 %)
Total number of binary PPIs (saturation %)208 (15.69 %)
The number (and %) of affected PPIs52 (25.00 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI7.038
Assortativity coefficient-0.3199
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients6 (11.54 %)
The number (and %) of a zero Betweenness Centrality14 (26.92 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZMYND11 All fusions
Proteins found in more fusions ZMYND11 (see 1 fusions); BMPR1A (see 1 fusions); TRAF6 (see 1 fusions); SNRNP200 (see 3 fusions); PABPC1 (see 2 fusions); EZH2 (see 1 fusions); PRPF8 (see 3 fusions); PIAS1 (see 2 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SRSF1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZMYND11parental protein520.1041853.252DUF1002 (PF06207, IPR009343): Protein of unknown function (DUF1002)
DUF1353 (PF07087, IPR010767): Protein of unknown function (DUF1353)
PWWP (PF00855, IPR000313, SM00293): PWWP domain
zf-MYND (PF01753, IPR002893): MYND finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
2 BMPR1Asuppressor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 CDK2suppressor110.33322.667Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 E2F6oncoprotein40.8330.667BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
5 EFTUD2interactor90.6078.119EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
6 ELAVL1oncoprotein130.37928.619RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 EMSYoncoprotein31.0000ENT (PF03735, IPR005491): ENT domain
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
GTA_TIM (PF13547, IPR025195): GTA TIM-barrel-like domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
8 EP400oncoprotein31.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
DDHD (PF02862, IPR004177, SM01127): DDHD domain
GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
HSA (PF07529, IPR014012, SM00573): HSA
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
EP400_N (PF15790, IPR031575): E1A-binding protein p400, N-terminal
9 ETS2suppressor31.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
10 EZH1suppressor41.0000TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
11 EZH2suppressor120.32729.633CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
12 GBAinteractor100Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
13 H3F3Aoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HDAC1suppressor130.28841.467FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
15 HIST3H3interactor40.8330.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HOXD4interactor100SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
17 LTBRoncoprotein60.9000.400Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
18 MAGEC2interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
APOC4 (PF15119, IPR028120): Apolipoprotein C4
19 MAGOHBinteractor21.0000Mago_nashi (PF02792, IPR004023): Mago nashi protein
20 MYBoncoprotein60.6673.500Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
21 NCOR1oncoprotein70.6195.667BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
22 PABPC1oncoprotein90.46411.300RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
23 PDLIM7interactor70.6194.733LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
24 PIAS1suppressor70.8001.667Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
25 PNNsuppressor80.5368.700Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
26 PPIGinteractor31.0000Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
27 PRPF8oncoprotein90.6075.433PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
28 RNU4-1interactor100NA
29 RNU5A-1interactor21.0000NA
30 RNU6-1interactor100NA
31 RPL10suppressor30.6671.000Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
32 SAP18interactor60.5333.519SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
33 SMAD2suppressor70.7331.733MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
34 SMAD3oncoprotein70.7332.167MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
35 SMARCA2suppressor40.6671.167DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
36 SNRNP200protein found in more fusions100.5837.219DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
37 SRPK1interactor90.52811.167FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
38 SRRM1interactor90.5289.433DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
PWI (PF01480, IPR002483, SM00311): PWI domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
39 SRRM2interactor110.52712.686cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
40 SRSF1protein found in more fusions160.34348.933Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
41 SRSF10interactor50.7001.567RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
42 SRSF4interactor60.6672.686Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
43 TAB1interactor40.6672.000PP2C (PF00481, IPR001932): Protein phosphatase 2C
44 TP53suppressor170.32562.133DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
45 TRADDinteractor60.9000.400Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
46 TRAF1oncoprotein70.7332.000HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
47 TRAF2interactor120.47320.133MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
48 TRAF3oncoprotein80.6194.533ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
49 TRAF5interactor80.6194.500Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
50 TRAF6protein found in more fusions100.47213.533SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
51 UBE2Iinteractor150.31946.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
52 ZHX1interactor50.8330.500Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain

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