Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZBTB16 (from a repository: Thu Nov 17 17:25:05 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 115 The number (and %) of the onco-proteins 34 (29.57 %) The number (and %) of the tumor suppressors 17 (14.78 %) Total number of binary PPIs (saturation %) 546 (8.33 %) The number (and %) of affected PPIs 115 (21.06 %) The number of possible different fusions 21 PPI diameter 2 PPI radius 1 The average degree of PPI 8.504 Assortativity coefficient -0.3502 The network average Clustering coefficient 0.485 The number (and %) of a zero Clustering coefficients 23 (20.00 %) The number (and %) of a zero Betweenness Centrality 42 (36.52 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ZBTB16	All fusions
Proteins found in more fusions	TAB2 (see 1 fusions); RARA/PML (see 20 fusions); VDR (see 2 fusions); CEP70 (see 1 fusions); NR3C1 (see 8 fusions); HDAC7 (see 1 fusions); BCL6 (see 2 fusions); HDAC4 (see 1 fusions); RUNX1T1 (see 1 fusions); TXNIP (see 2 fusions); RARA (see 4 fusions); RXRA (see 2 fusions); HDAC5 (see 1 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRKCE (see 3 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ZBTB16	parental protein	115	0.058	10100.651	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
2	ADAMTS4	interactor	1	0	0	ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1 Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease Toxin_21 (PF08091, IPR012626): Spider insecticidal peptide TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3	AGTR2	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4	ANAPC5	interactor	2	1.000	0	TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
5	ANXA7	suppressor	4	0.667	0.833	Annexin (PF00191, IPR018502, SM00335): Annexin
6	AR	oncoprotein	22	0.357	74.535	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
7	ATP6AP2	interactor	3	1.000	0	Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase Renin_r (PF07850, IPR012493): Renin receptor-like protein
8	ATP7B	interactor	1	0	0	E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase HMA (PF00403, IPR006121): Heavy-metal-associated domain Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
9	BCL6	oncoprotein	18	0.463	49.017	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10	BMI1	oncoprotein	15	0.308	48.286	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11	C16orf70	interactor	1	0	0	UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
12	CASP3	interactor	5	0.667	0.733	Peptidase_C14 (PF00656, IPR011600): Caspase domain
13	CBX5	suppressor	4	0.667	1.000	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
14	CCDC130	interactor	4	0.667	1.667	DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
15	CCDC85B	interactor	4	0.500	2.000	CCDC85 (PF10226, IPR019359): CCDC85 family
16	CD81	interactor	3	1.000	0	Tetraspannin (PF00335, IPR018499): Tetraspanin family
17	CDK1	oncoprotein	9	0.679	2.239	Pkinase (PF00069, IPR000719): Protein kinase domain
18	CDK4	oncoprotein	8	0.393	13.500	Pkinase (PF00069, IPR000719): Protein kinase domain
19	CDKN1A	suppressor	22	0.316	103.316	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
20	CEBPA	suppressor	13	0.545	10.694	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21	CEP70	protein found in more fusions	6	0.400	5.000	IncA (PF04156, IPR007285): IncA protein Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
22	CEP72	interactor	1	0	0	LRR_9 (PF14580): Leucine-rich repeat FAM76 (PF16046, IPR032017): FAM76 protein
23	CFH	oncoprotein	4	1.000	0	DUF1962 (PF09227, IPR015308): Domain of unknown function (DUF1962) Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
24	CIDEA	interactor	1	0	0	CIDE-N (PF02017, IPR003508): CIDE-N domain DUF3721 (PF12518, IPR022196): Protein of unknown function
25	COQ6	interactor	2	0	0	FAD_binding_3 (PF01494, IPR002938): FAD binding domain Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
26	DLST	oncoprotein	2	1.000	0	2-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
27	DNAAF5	interactor	1	0	0	HEAT (PF02985, IPR000357): HEAT repeat Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
28	DNM2	interactor	3	0.667	0.667	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
29	DPM1	interactor	2	1.000	0	Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
30	EEF1A1	suppressor	15	0.275	51.867	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31	EIF2S2	interactor	3	1.000	0	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 Cytochrom_c3_2 (PF14537): Cytochrome c3
32	ENOX1	interactor	2	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
33	EP300	oncoprotein	33	0.250	244.064	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
34	ESR1	suppressor	28	0.342	141.112	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35	FCHO1	interactor	1	0	0	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
36	FHL2	oncoprotein	7	0.733	1.518	LIM (PF00412, IPR001781, SM00132): LIM domain zf-ribbon_3 (PF13248): zinc-ribbon domain
37	FHL3	interactor	8	0.571	4.465	LIM (PF00412, IPR001781, SM00132): LIM domain Med27 (PF11571, IPR021627): Mediator complex subunit 27
38	FSHR	interactor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
39	GATA1	oncoprotein	8	0.536	5.010	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
40	GATA2	oncoprotein	11	0.345	22.703	GATA (PF00320, IPR000679, SM00401): GATA zinc finger
41	GCSH	interactor	1	0	0	GCV_H (PF01597, IPR002930): Glycine cleavage H-protein
42	GOLGA2	interactor	8	0.464	7.612	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
43	GRB7	interactor	1	0	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
44	GSTM4	interactor	3	1.000	0	GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
45	HBEGF	interactor	2	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain
46	HDAC1	suppressor	28	0.419	80.005	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
47	HDAC2	suppressor	20	0.497	32.045	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
48	HDAC3	suppressor	19	0.464	31.904	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
49	HDAC4	oncoprotein	20	0.427	50.810	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
50	HDAC5	protein found in more fusions	23	0.403	68.969	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
51	HDAC6	oncoprotein	9	0.393	11.945	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
52	HDAC7	protein found in more fusions	14	0.744	3.709	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
53	HDX	interactor	1	0	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
54	IL32	interactor	4	1.000	0	IL32 (PF15225, IPR028067): Interleukin 32
55	IL6	oncoprotein	1	0	0	IL6 (PF00489, IPR003573, SM00126): Interleukin-6/G-CSF/MGF family
56	KRT40	interactor	4	0.500	1.567	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
57	KRTAP4-12	interactor	4	1.000	0	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
58	LAMTOR5	interactor	6	0.467	7.500	LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
59	LDOC1	oncoprotein	5	0.500	1.833	DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
60	LMTK3	interactor	1	0	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
61	LSM2	interactor	3	0.667	1.000	LSM (PF01423, IPR001163): LSM domain
62	LYAR	interactor	3	0.667	0.667	DEK_C (PF08766, IPR014876): DEK C terminal domain zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
63	MAGEA11	interactor	8	0.429	8.605	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
64	MAP3K3	oncoprotein	2	0	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
65	MBD3	interactor	12	0.455	16.297	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
66	MCUB	interactor	1	0	0	MCU (PF04678, IPR006769): Mitochondrial calcium uniporter UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
67	MTA2	interactor	10	0.711	3.385	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
68	MTDH	interactor	2	1.000	0	NST1 (PF13945, IPR025279): Salt tolerance down-regulator NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
69	MX1	interactor	4	1.000	0	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
70	NCOR1	oncoprotein	21	0.538	26.997	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
71	NCOR2	oncoprotein	22	0.532	32.679	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
72	NLRP7	interactor	1	0	0	NACHT (PF05729): NACHT domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
73	NR3C1	protein found in more fusions	16	0.505	21.635	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
74	PAFAH1B3	interactor	5	0.667	1.333	Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
75	PARP1	suppressor	15	0.560	16.481	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
76	PGAM5	interactor	4	0.667	0.619	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
77	PLSCR1	interactor	5	0.500	3.451	Scramblase (PF03803, IPR005552): Scramblase
78	PMAIP1	interactor	1	0	0	PMAIP1 (PF15150, IPR024140): Phorbol-12-myristate-13-acetate-induced
79	PML	suppressor	25	0.337	100.821	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
80	PRKCE	suppressor	4	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
81	PSMD11	interactor	6	0.667	2.633	DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat
82	PSMD2	oncoprotein	5	0.500	2.148	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
83	QTRT1	interactor	1	0	0	TGT (PF01702, IPR002616): Queuine tRNA-ribosyltransferase
84	RAB27A	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
85	RARA	oncoprotein	16	0.476	27.436	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
86	RFLNB	interactor	1	0	0	FAM101 (PF15068, IPR028215): FAM101 family
87	RUNX1T1	oncoprotein	11	0.578	10.683	NHR2 (PF08788, IPR014896): NHR2 domain like TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF zf-MYND (PF01753, IPR002893): MYND finger DUF3731 (PF12531, IPR021030): DNA-K related protein
88	RXRA	oncoprotein	14	0.500	21.837	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
89	SH2D4A	interactor	8	0.286	16.667	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2039 (PF10217, IPR019351): Uncharacterized conserved protein (DUF2039)
90	SIN3A	oncoprotein	20	0.495	40.728	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
91	SIN3B	interactor	8	0.821	1.568	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
92	SMAD3	oncoprotein	20	0.415	52.762	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
93	SMN1	interactor	10	0.444	13.650	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
94	SPOP	suppressor	5	0.667	0.403	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain MATH (PF00917, IPR002083, SM00061): MATH domain
95	SPRY2	suppressor	7	0.400	8.333	KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9 Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
96	SUMO1	interactor	9	0.607	7.358	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
97	TAB2	oncoprotein	12	0.600	10.100	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
98	TERF1	interactor	6	0.400	5.167	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
99	THNSL2	interactor	1	0	0	PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme Thr_synth_N (PF14821, IPR029144): Threonine synthase N terminus
100	TIMP1	oncoprotein	1	0	0	TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
101	TK1	oncoprotein	7	0.600	2.869	TK (PF00265, IPR001267, SM00203): Thymidine kinase
102	TNK2	interactor	5	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
103	TOLLIP	interactor	2	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
104	TP53	suppressor	37	0.243	328.847	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
105	TRAF2	interactor	8	0.333	11.483	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
106	TRIM27	oncoprotein	12	0.418	20.157	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
107	TRIM54	interactor	6	0.400	4.015	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) zf-HIT (PF04438, IPR007529): HIT zinc finger zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
108	TXNIP	suppressor	6	0.500	2.198	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
109	UBE2I	interactor	26	0.360	108.307	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
110	VDR	suppressor	12	0.564	9.940	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
111	VTA1	interactor	3	0.667	1.000	Vta1 (PF04652): Vta1 like
112	WDR33	interactor	4	0.667	1.333	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
113	ZBTB32	interactor	4	0.500	1.467	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
114	ZNF24	interactor	5	0.700	2.167	SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
115	ZNF281	oncoprotein	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger GRP (PF07172, IPR010800): Glycine rich protein family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 zf-C2H2_4 (PF13894): C2H2-type zinc finger

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