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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)115
The number (and %) of the onco-proteins34 (29.57 %)
The number (and %) of the tumor suppressors17 (14.78 %)
Total number of binary PPIs (saturation %)546 (8.33 %)
The number (and %) of affected PPIs115 (21.06 %)
The number of possible different fusions21
PPI diameter2
PPI radius1
The average degree of PPI8.504
Assortativity coefficient-0.3502
The network average Clustering coefficient0.485
The number (and %) of a zero Clustering coefficients23 (20.00 %)
The number (and %) of a zero Betweenness Centrality42 (36.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZBTB16 All fusions
Proteins found in more fusions TAB2 (see 1 fusions); RARA/PML (see 20 fusions); VDR (see 2 fusions); CEP70 (see 1 fusions); NR3C1 (see 8 fusions); HDAC7 (see 1 fusions); BCL6 (see 2 fusions); HDAC4 (see 1 fusions); RUNX1T1 (see 1 fusions); TXNIP (see 2 fusions); RARA (see 4 fusions); RXRA (see 2 fusions); HDAC5 (see 1 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRKCE (see 3 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZBTB16parental protein1150.05810100.651BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
2 ADAMTS4interactor100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
Toxin_21 (PF08091, IPR012626): Spider insecticidal peptide
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 AGTR2interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ANAPC5interactor21.0000TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
5 ANXA7suppressor40.6670.833Annexin (PF00191, IPR018502, SM00335): Annexin
6 ARoncoprotein220.35774.535Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
7 ATP6AP2interactor31.0000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
8 ATP7Binteractor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
9 BCL6oncoprotein180.46349.017BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10 BMI1oncoprotein150.30848.286zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11 C16orf70interactor100UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
12 CASP3interactor50.6670.733Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CBX5suppressor40.6671.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
14 CCDC130interactor40.6671.667DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
15 CCDC85Binteractor40.5002.000CCDC85 (PF10226, IPR019359): CCDC85 family
16 CD81interactor31.0000Tetraspannin (PF00335, IPR018499): Tetraspanin family
17 CDK1oncoprotein90.6792.239Pkinase (PF00069, IPR000719): Protein kinase domain
18 CDK4oncoprotein80.39313.500Pkinase (PF00069, IPR000719): Protein kinase domain
19 CDKN1Asuppressor220.316103.316CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
20 CEBPAsuppressor130.54510.694Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21 CEP70protein found in more fusions60.4005.000IncA (PF04156, IPR007285): IncA protein
Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
22 CEP72interactor100LRR_9 (PF14580): Leucine-rich repeat
FAM76 (PF16046, IPR032017): FAM76 protein
23 CFHoncoprotein41.0000DUF1962 (PF09227, IPR015308): Domain of unknown function (DUF1962)
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
24 CIDEAinteractor100CIDE-N (PF02017, IPR003508): CIDE-N domain
DUF3721 (PF12518, IPR022196): Protein of unknown function
25 COQ6interactor200FAD_binding_3 (PF01494, IPR002938): FAD binding domain
Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
26 DLSToncoprotein21.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
27 DNAAF5interactor100HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
28 DNM2interactor30.6670.667Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
29 DPM1interactor21.0000Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
30 EEF1A1suppressor150.27551.867GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31 EIF2S2interactor31.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
Cytochrom_c3_2 (PF14537): Cytochrome c3
32 ENOX1interactor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
33 EP300oncoprotein330.250244.064Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
34 ESR1suppressor280.342141.112Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35 FCHO1interactor100FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
36 FHL2oncoprotein70.7331.518LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
37 FHL3interactor80.5714.465LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
38 FSHRinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
39 GATA1oncoprotein80.5365.010GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
40 GATA2oncoprotein110.34522.703GATA (PF00320, IPR000679, SM00401): GATA zinc finger
41 GCSHinteractor100GCV_H (PF01597, IPR002930): Glycine cleavage H-protein
42 GOLGA2interactor80.4647.612ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
43 GRB7interactor100BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
44 GSTM4interactor31.0000GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
45 HBEGFinteractor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
46 HDAC1suppressor280.41980.005FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
47 HDAC2suppressor200.49732.045Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
48 HDAC3suppressor190.46431.904Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
49 HDAC4oncoprotein200.42750.810Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
50 HDAC5protein found in more fusions230.40368.969Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
51 HDAC6oncoprotein90.39311.945Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
52 HDAC7protein found in more fusions140.7443.709Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
53 HDXinteractor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
54 IL32interactor41.0000IL32 (PF15225, IPR028067): Interleukin 32
55 IL6oncoprotein100IL6 (PF00489, IPR003573, SM00126): Interleukin-6/G-CSF/MGF family
56 KRT40interactor40.5001.567Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
57 KRTAP4-12interactor41.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
58 LAMTOR5interactor60.4677.500LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
59 LDOC1oncoprotein50.5001.833DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
60 LMTK3interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
61 LSM2interactor30.6671.000LSM (PF01423, IPR001163): LSM domain
62 LYARinteractor30.6670.667DEK_C (PF08766, IPR014876): DEK C terminal domain
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
63 MAGEA11interactor80.4298.605MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
64 MAP3K3oncoprotein200PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
65 MBD3interactor120.45516.297DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
66 MCUBinteractor100MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
67 MTA2interactor100.7113.385BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
68 MTDHinteractor21.0000NST1 (PF13945, IPR025279): Salt tolerance down-regulator
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
69 MX1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
70 NCOR1oncoprotein210.53826.997BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
71 NCOR2oncoprotein220.53232.679CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
72 NLRP7interactor100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
73 NR3C1protein found in more fusions160.50521.635GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
74 PAFAH1B3interactor50.6671.333Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
75 PARP1suppressor150.56016.481BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
76 PGAM5interactor40.6670.619His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
77 PLSCR1interactor50.5003.451Scramblase (PF03803, IPR005552): Scramblase
78 PMAIP1interactor100PMAIP1 (PF15150, IPR024140): Phorbol-12-myristate-13-acetate-induced
79 PMLsuppressor250.337100.821zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
80 PRKCEsuppressor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
81 PSMD11interactor60.6672.633DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
82 PSMD2oncoprotein50.5002.148PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
83 QTRT1interactor100TGT (PF01702, IPR002616): Queuine tRNA-ribosyltransferase
84 RAB27Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
85 RARAoncoprotein160.47627.436zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
86 RFLNBinteractor100FAM101 (PF15068, IPR028215): FAM101 family
87 RUNX1T1oncoprotein110.57810.683NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
88 RXRAoncoprotein140.50021.837zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
89 SH2D4Ainteractor80.28616.667Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2039 (PF10217, IPR019351): Uncharacterized conserved protein (DUF2039)
90 SIN3Aoncoprotein200.49540.728Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
91 SIN3Binteractor80.8211.568Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
92 SMAD3oncoprotein200.41552.762MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
93 SMN1interactor100.44413.650SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
94 SPOPsuppressor50.6670.403BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
95 SPRY2suppressor70.4008.333KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
96 SUMO1interactor90.6077.358Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
97 TAB2oncoprotein120.60010.100CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
98 TERF1interactor60.4005.167TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
99 THNSL2interactor100PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
Thr_synth_N (PF14821, IPR029144): Threonine synthase N terminus
100 TIMP1oncoprotein100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
101 TK1oncoprotein70.6002.869TK (PF00265, IPR001267, SM00203): Thymidine kinase
102 TNK2interactor51.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
103 TOLLIPinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
104 TP53suppressor370.243328.847DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
105 TRAF2interactor80.33311.483MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
106 TRIM27oncoprotein120.41820.157IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
107 TRIM54interactor60.4004.015DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
108 TXNIPsuppressor60.5002.198Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
109 UBE2Iinteractor260.360108.307UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
110 VDRsuppressor120.5649.940zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
111 VTA1interactor30.6671.000Vta1 (PF04652): Vta1 like
112 WDR33interactor40.6671.333Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
113 ZBTB32interactor40.5001.467BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
114 ZNF24interactor50.7002.167SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
115 ZNF281oncoprotein21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
GRP (PF07172, IPR010800): Glycine rich protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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