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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZAK (from a repository: Mon Dec 5 00:23:22 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins9 (23.68 %)
The number (and %) of the tumor suppressors5 (13.16 %)
Total number of binary PPIs (saturation %)99 (14.08 %)
The number (and %) of affected PPIs38 (38.38 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.474
Assortativity coefficient-0.3622
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients8 (21.05 %)
The number (and %) of a zero Betweenness Centrality20 (52.63 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K20 All fusions
: AW629613;
Proteins found in more fusions SMARCB1 (see 12 fusions); NEDD4L (see 3 fusions); YWHAZ (see 1 fusions); EZH2 (see 1 fusions); MYC (see 1 fusions); ZAK (see 2 fusions); SRPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZAKparental protein380.0721085.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
2 CCDC69interactor100NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
DUF2441 (PF10386, IPR018840): Protein of unknown function (DUF2441)
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
3 CDC42oncoprotein70.5336.333Ras (PF00071, IPR001806, SM00173): Ras family
4 CRMP1interactor31.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
5 DDAH2interactor21.0000Amidinotransf (PF02274, IPR003198): Amidinotransferase
6 ELAVL1oncoprotein140.25655.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 EMC2interactor100TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
8 EZH2suppressor50.6672.000CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
9 IGHMinteractor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
10 ITSN1interactor60.6003.333C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
11 MAP2K7interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
12 MIDNinteractor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
13 MPP1oncoprotein100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
14 MYConcoprotein70.6673.400HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
15 NEDD4Lsuppressor70.6673.233WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
16 PARD6Ainteractor40.6672.000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
17 RAB5Aoncoprotein30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
18 RBX1oncoprotein41.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
19 RNF19Ainteractor21.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
20 RPL10suppressor21.0000Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
21 RPS6KA5interactor100.22234.667Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
22 SFNsuppressor50.6672.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
23 SMARCB1suppressor50.6671.667SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
24 SRPK2oncoprotein40.6671.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
25 TGFBR1oncoprotein40.8330.667Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
26 UNC119interactor40.8330.667GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
27 VPS33Binteractor21.0000Sec1 (PF00995, IPR001619): Sec1 family
28 XPO1interactor80.46412.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
29 XRCC1interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
SPX (PF03105, IPR004331): SPX domain
XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
30 YWHABinteractor70.42910.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
31 YWHAZprotein found in more fusions80.42910.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 ZFP2interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
33 ZNF33Ainteractor100HNH (PF01844, IPR002711): HNH endonuclease
KRAB (PF01352, IPR001909, SM00349): KRAB box
XPA_N (PF01286, IPR022652): XPA protein N-terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
34 ZNF567interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
35 ZNF593interactor21.0000DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
36 ZNF746interactor21.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
37 ZNF775interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
38 ZWINTinteractor200Zwint (PF15556, IPR029092): ZW10 interactor

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