1 |
YWHAZ | parental protein | 335 | 0.049 | 63934.846 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
2 |
AANAT | interactor | 1 | 0 | 0 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family |
3 |
ABL1 | oncoprotein | 32 | 0.385 | 84.518 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
4 |
ADORA3 | interactor | 2 | 1.000 | 0 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
5 |
AJUBA | oncoprotein | 7 | 0.429 | 5.029 | LIM (PF00412, IPR001781, SM00132): LIM domain |
6 |
AKT1 | oncoprotein | 41 | 0.208 | 270.554 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
7 |
AKT1S1 | interactor | 10 | 0.444 | 6.143 | Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1 |
8 |
AP3B1 | interactor | 7 | 0.333 | 3.419 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex |
9 |
APP | protein found in more fusions | 72 | 0.096 | 1458.099 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
10 |
ARAF | oncoprotein | 15 | 0.562 | 16.886 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
11 |
ARHGEF2 | oncoprotein | 15 | 0.495 | 12.858 | IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
12 |
ARRB1 | interactor | 27 | 0.308 | 98.105 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
13 |
ATG9A | interactor | 3 | 1.000 | 0 | APG9 (PF04109, IPR007241): Autophagy protein Apg9 PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b |
14 |
ATP5A1 | protein found in more fusions | 35 | 0.431 | 63.344 | ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain |
15 |
B4GALT7 | interactor | 1 | 0 | 0 | Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7 |
16 |
BAD | oncoprotein | 20 | 0.389 | 54.740 | Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD |
17 |
BAG3 | oncoprotein | 29 | 0.249 | 137.683 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
18 |
BARD1 | suppressor | 22 | 0.310 | 59.045 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
19 |
BCAR1 | oncoprotein | 9 | 0.528 | 9.283 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain |
20 |
BDP1 | interactor | 1 | 0 | 0 | SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DUF2917 (PF11142, IPR021317): Protein of unknown function (DUF2917) UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542 Myb_DNA-bind_7 (PF15963): Myb DNA-binding like |
21 |
BRAF | oncoprotein | 17 | 0.583 | 18.226 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
22 |
BRCA1 | suppressor | 35 | 0.251 | 185.981 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
23 |
BRD4 | oncoprotein | 8 | 0.643 | 3.737 | Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4 |
24 |
BTRC | oncoprotein | 30 | 0.298 | 111.770 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
25 |
CAPNS1 | interactor | 14 | 0.516 | 11.753 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
26 |
CBL | suppressor | 28 | 0.362 | 80.205 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
27 |
CBX4 | oncoprotein | 8 | 0.619 | 2.552 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region CBX7_C (PF17218): CBX family C-terminal motif |
28 |
CCDC84 | interactor | 1 | 0 | 0 | CCDC84 (PF14968, IPR028015): Coiled coil protein 84 |
29 |
CDC25A | oncoprotein | 16 | 0.525 | 11.662 | M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
30 |
CDC25B | oncoprotein | 13 | 0.577 | 8.265 | M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
31 |
CDC25C | oncoprotein | 11 | 0.655 | 3.654 | M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
32 |
CDC5L | interactor | 46 | 0.252 | 337.259 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
33 |
CDCA7 | interactor | 5 | 0.600 | 0.346 | zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1 Imm51 (PF15595, IPR028956): Immunity protein 51 |
34 |
CDK11B | oncoprotein | 9 | 0.714 | 2.660 | DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) |
35 |
CDK16 | oncoprotein | 10 | 0.644 | 1.948 | Pkinase (PF00069, IPR000719): Protein kinase domain |
36 |
CDK2 | suppressor | 54 | 0.235 | 425.854 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
37 |
CDKN1B | suppressor | 20 | 0.395 | 37.528 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH |
38 |
CENPJ | interactor | 16 | 0.267 | 45.489 | DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) |
39 |
CEP126 | interactor | 2 | 1.000 | 0 | Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa) K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy |
40 |
CGNL1 | interactor | 3 | 1.000 | 0 | Abhydrolase_4 (PF08386, IPR013595): TAP-like protein Myosin_tail_1 (PF01576, IPR002928): Myosin tail |
41 |
CHAF1A | interactor | 12 | 0.455 | 7.038 | CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA |
42 |
CLK3 | interactor | 11 | 0.356 | 6.662 | Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
43 |
COPB1 | protein found in more fusions | 20 | 0.404 | 21.199 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform |
44 |
COPS5 | protein found in more fusions | 57 | 0.253 | 433.755 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
45 |
COPS7B | interactor | 11 | 0.600 | 7.963 | PCI (PF01399, IPR000717, SM00088): PCI domain |
46 |
CRY1 | interactor | 18 | 0.434 | 17.003 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
47 |
CSF2RB | interactor | 2 | 0 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Tissue_fac (PF01108, IPR003961): Tissue factor |
48 |
CSNK1D | interactor | 9 | 0.333 | 10.638 | Pkinase (PF00069, IPR000719): Protein kinase domain |
49 |
CTNNB1 | oncoprotein | 40 | 0.249 | 202.920 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
50 |
CUL1 | suppressor | 48 | 0.302 | 220.433 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
51 |
CUL2 | suppressor | 35 | 0.303 | 133.673 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
52 |
CUL3 | protein found in more fusions | 64 | 0.249 | 557.774 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
53 |
CUL7 | protein found in more fusions | 43 | 0.292 | 188.860 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
54 |
CWC27 | interactor | 2 | 1.000 | 0 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
55 |
CYFIP1 | interactor | 5 | 0.600 | 1.225 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family |
56 |
CYFIP2 | interactor | 8 | 0.607 | 3.467 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger |
57 |
DCAF7 | interactor | 14 | 0.495 | 12.700 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
58 |
DDIT4 | interactor | 4 | 0.667 | 0.237 | RTP801_C (PF07809, IPR012918): RTP801 C-terminal region |
59 |
DFFA | suppressor | 12 | 0.455 | 9.796 | CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus |
60 |
DISC1 | interactor | 8 | 0.643 | 6.509 | HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding |
61 |
DMTN | interactor | 8 | 0.464 | 2.866 | VHP (PF02209, IPR003128, SM00153): Villin headpiece domain AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM |
62 |
DNAJB4 | suppressor | 6 | 0.600 | 1.462 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
63 |
DOCK7 | interactor | 16 | 0.400 | 19.359 | DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus |
64 |
DTL | interactor | 10 | 0.600 | 2.354 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
65 |
ECHS1 | protein found in more fusions | 14 | 0.385 | 18.230 | ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase |
66 |
ECT2 | suppressor | 11 | 0.327 | 15.836 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal |
67 |
EDC3 | protein found in more fusions | 7 | 0.867 | 0.096 | FDF (PF09532, IPR019050, SM01199): FDF domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus LSM14 (PF12701, IPR025609): Scd6-like Sm domain Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3 DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096) |
68 |
EFNB3 | interactor | 1 | 0 | 0 | Ephrin (PF00812, IPR001799): Ephrin |
69 |
EGFR | oncoprotein | 56 | 0.193 | 590.944 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
70 |
EIF3A | oncoprotein | 18 | 0.320 | 30.419 | DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
71 |
EIF4B | interactor | 15 | 0.484 | 11.102 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3774 (PF12609, IPR022251): Wound-induced protein PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family |
72 |
EIF5 | interactor | 18 | 0.595 | 15.336 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon |
73 |
ENO1 | oncoprotein | 39 | 0.294 | 184.460 | Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain |
74 |
EP300 | oncoprotein | 42 | 0.174 | 390.887 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
75 |
EPB41L2 | interactor | 7 | 0.714 | 1.378 | 4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain SAB (PF04382, IPR007477): SAB domain TCP (PF03634, IPR005333): TCP family transcription factor |
76 |
EPB41L3 | suppressor | 15 | 0.467 | 29.274 | 4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain |
77 |
ERP44 | interactor | 14 | 0.385 | 27.672 | Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain |
78 |
ERRFI1 | suppressor | 10 | 0.611 | 7.697 | GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 |
79 |
EWSR1 | oncoprotein | 43 | 0.245 | 296.132 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
80 |
EXO1 | interactor | 7 | 0.857 | 0.130 | XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain |
81 |
FAM13B | interactor | 4 | 1.000 | 0 | COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MazG (PF03819, IPR004518): MazG nucleotide pyrophosphohydrolase domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Drc1-Sld2 (PF11719, IPR021110): DNA replication and checkpoint protein GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking |
82 |
FAM189A2 | interactor | 8 | 0.500 | 5.948 | CD20 (PF04103, IPR007237): CD20-like family |
83 |
FAM53C | interactor | 5 | 0.800 | 0.128 | FAM53 (PF15242, IPR029356): Family of FAM53 |
84 |
FAM65B | interactor | 3 | 0.667 | 0.167 | Glu-tRNAGln (PF02686, IPR003837): Glu-tRNAGln amidotransferase C subunit HEAT_2 (PF13646): HEAT repeats PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65 |
85 |
FAN1 | protein found in more fusions | 4 | 0.667 | 0.056 | VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TPR_12 (PF13424): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) |
86 |
FBXO6 | interactor | 35 | 0.254 | 154.253 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
87 |
FBXW11 | interactor | 37 | 0.259 | 185.626 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
88 |
FERMT2 | interactor | 17 | 0.449 | 26.740 | FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
89 |
FHOD1 | interactor | 7 | 0.733 | 0.939 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain |
90 |
FN1 | oncoprotein | 49 | 0.269 | 253.733 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
91 |
FOXO1 | suppressor | 9 | 0.464 | 4.475 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
92 |
FOXO3 | suppressor | 16 | 0.442 | 17.900 | Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
93 |
FUS | suppressor | 37 | 0.428 | 102.356 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
94 |
G6PD | protein found in more fusions | 24 | 0.522 | 40.889 | G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain |
95 |
GABARAPL2 | interactor | 12 | 0.288 | 23.167 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
96 |
GCH1 | interactor | 3 | 1.000 | 0 | GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I |
97 |
GINS4 | interactor | 3 | 0.667 | 0.400 | Sld5 (PF05916, IPR021151): GINS complex protein SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus |
98 |
GP1BA | interactor | 1 | 0 | 0 | LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
99 |
GP1BB | interactor | 1 | 0 | 0 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
100 |
GRB2 | oncoprotein | 47 | 0.277 | 345.748 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
101 |
GRK5 | protein found in more fusions | 19 | 0.242 | 64.540 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
102 |
H2AFX | suppressor | 25 | 0.403 | 58.321 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
103 |
HDAC4 | oncoprotein | 19 | 0.451 | 37.361 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
104 |
HDAC5 | protein found in more fusions | 43 | 0.274 | 245.311 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
105 |
HDAC6 | oncoprotein | 26 | 0.293 | 89.037 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
106 |
HDAC7 | protein found in more fusions | 20 | 0.433 | 32.713 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO |
107 |
HDAC9 | interactor | 9 | 0.536 | 4.207 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein |
108 |
HIST1H3A | interactor | 27 | 0.338 | 92.051 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
109 |
HIST1H4A | interactor | 28 | 0.307 | 95.258 | CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold |
110 |
HIVEP2 | interactor | 6 | 0.800 | 0.363 | Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
111 |
HMGN1 | interactor | 4 | 1.000 | 0 | HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17 |
112 |
HNF1A | oncoprotein | 8 | 0.667 | 0.955 | HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
113 |
HNRNPA1 | interactor | 51 | 0.337 | 232.650 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
114 |
HNRNPL | protein found in more fusions | 22 | 0.490 | 14.978 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
115 |
HS6ST2 | interactor | 1 | 0 | 0 | Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family Clr2 (PF10383, IPR018839): Transcription-silencing protein Clr2 |
116 |
HSPA1B | interactor | 20 | 0.358 | 24.050 | HSP70 (PF00012, IPR013126): Hsp70 protein |
117 |
HSPB1 | oncoprotein | 51 | 0.259 | 372.072 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
118 |
HUWE1 | oncoprotein | 44 | 0.297 | 214.643 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
119 |
IL9R | interactor | 1 | 0 | 0 | NA |
120 |
ING1 | suppressor | 10 | 0.622 | 1.676 | PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta |
121 |
INPP5A | interactor | 1 | 0 | 0 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family Glyco_hydro_cc (PF11790, IPR024655): Glycosyl hydrolase catalytic core |
122 |
IRS2 | oncoprotein | 12 | 0.727 | 2.003 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
123 |
IRS4 | interactor | 20 | 0.516 | 18.914 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain |
124 |
ISOC1 | interactor | 13 | 0.718 | 6.115 | Isochorismatase (PF00857, IPR000868): Isochorismatase family Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain |
125 |
ITGA4 | interactor | 36 | 0.376 | 83.147 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
126 |
ITGB2 | interactor | 7 | 0.429 | 4.422 | EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain |
127 |
KAT8 | protein found in more fusions | 11 | 0.600 | 7.411 | MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain |
128 |
KIAA0232 | interactor | 2 | 1.000 | 0 | DUF4603 (PF15376, IPR027871): Domain of unknown function (DUF4603) |
129 |
KIAA0930 | interactor | 8 | 0.750 | 0.489 | DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045) |
130 |
KIF11 | protein found in more fusions | 14 | 0.333 | 28.819 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding |
131 |
KIF1C | interactor | 8 | 0.714 | 2.820 | FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Kinesin_assoc (PF16183, IPR032405): Kinesin-associated |
132 |
KIF23 | interactor | 15 | 0.390 | 23.083 | DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1 |
133 |
KIF5B | interactor | 20 | 0.442 | 31.513 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
134 |
KLC1 | interactor | 15 | 0.448 | 26.394 | Gly_radical (PF01228, IPR001150): Glycine radical SOGA (PF11365, IPR027881): Protein SOGA TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II |
135 |
KLC4 | interactor | 10 | 0.778 | 2.542 | Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat LUD_dom (PF02589): LUD domain |
136 |
KLF11 | interactor | 3 | 0.667 | 1.000 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
137 |
KLHL7 | interactor | 6 | 0.900 | 0.053 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_6 (PF13964): Kelch motif |
138 |
LARP1 | interactor | 20 | 0.437 | 35.582 | La (PF05383, IPR006630, SM00715): La domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
139 |
LCA5 | interactor | 11 | 0.509 | 12.856 | IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease |
140 |
LCP2 | interactor | 5 | 0.800 | 0.389 | SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain |
141 |
LDHB | interactor | 30 | 0.369 | 106.514 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
142 |
LIMK1 | oncoprotein | 9 | 0.393 | 6.779 | LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
143 |
LRMP | suppressor | 2 | 1.000 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 MRVI1 (PF05781, IPR008677): MRVI1 protein DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203) EF-hand_9 (PF14658): EF-hand domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
144 |
LRRK2 | oncoprotein | 15 | 0.516 | 18.430 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
145 |
LYST | interactor | 5 | 0.800 | 0.650 | Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4800 (PF16057): Domain of unknown function (DUF4800) |
146 |
MADD | suppressor | 6 | 0.467 | 3.640 | DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus uDENN (PF03456, IPR005113, SM00800): uDENN domain |
147 |
MAP2K1 | oncoprotein | 13 | 0.530 | 14.663 | Pkinase (PF00069, IPR000719): Protein kinase domain DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216) |
148 |
MAP2K5 | oncoprotein | 12 | 0.364 | 22.264 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain |
149 |
MAP3K2 | protein found in more fusions | 14 | 0.449 | 18.205 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain |
150 |
MAP3K4 | suppressor | 6 | 0.500 | 3.150 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pkinase (PF00069, IPR000719): Protein kinase domain PLU-1 (PF08429, IPR013637): PLU-1-like protein Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958) |
151 |
MAP3K5 | oncoprotein | 11 | 0.467 | 7.376 | Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071) |
152 |
MAPK7 | oncoprotein | 20 | 0.398 | 37.444 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
153 |
MAPK8 | oncoprotein | 24 | 0.209 | 114.600 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
154 |
MAPKAPK2 | oncoprotein | 11 | 0.444 | 10.094 | Pkinase (PF00069, IPR000719): Protein kinase domain |
155 |
MAPRE1 | oncoprotein | 25 | 0.275 | 89.705 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
156 |
MAPT | protein found in more fusions | 22 | 0.310 | 63.474 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
157 |
MARK1 | interactor | 7 | 0.619 | 1.431 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
158 |
MARK2 | protein found in more fusions | 26 | 0.410 | 70.805 | DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
159 |
MARK3 | protein found in more fusions | 16 | 0.705 | 7.294 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
160 |
MAST1 | interactor | 7 | 0.619 | 1.479 | DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain |
161 |
MCM2 | oncoprotein | 56 | 0.325 | 300.571 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
162 |
MDC1 | suppressor | 19 | 0.357 | 54.606 | FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
163 |
MDM4 | oncoprotein | 15 | 0.516 | 8.646 | zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
164 |
MEF2C | oncoprotein | 8 | 0.393 | 5.756 | SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat |
165 |
MEPCE | interactor | 14 | 0.319 | 32.376 | Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7 |
166 |
MEX3B | interactor | 5 | 1.000 | 0 | KH_1 (PF00013, IPR004088, SM00322): KH domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
167 |
MGMT | interactor | 10 | 0.533 | 5.160 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
168 |
MOV10 | interactor | 48 | 0.145 | 447.649 | AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain |
169 |
MPHOSPH9 | interactor | 4 | 0.833 | 0.182 | CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus IL15 (PF02372, IPR003443): Interleukin 15 Tup_N (PF08581, IPR013890): Tup N-terminal KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
170 |
MSL2 | interactor | 6 | 0.733 | 0.855 | MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2 zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2 |
171 |
MST1R | suppressor | 10 | 0.778 | 1.048 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain |
172 |
MTOR | oncoprotein | 23 | 0.286 | 68.792 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
173 |
MYCBP2 | interactor | 11 | 0.509 | 9.358 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHR (PF08005, IPR012983): PHR domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SH3_3 (PF08239, IPR003646): Bacterial SH3 domain XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
174 |
MYH9 | suppressor | 29 | 0.283 | 126.463 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
175 |
NADK | interactor | 7 | 0.762 | 0.641 | NAD_kinase (PF01513, IPR002504): ATP-NAD kinase |
176 |
NBEAL2 | interactor | 2 | 1.000 | 0 | Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704) DUF4800 (PF16057): Domain of unknown function (DUF4800) |
177 |
NCAPD3 | interactor | 7 | 0.429 | 3.426 | DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013) CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain |
178 |
NCKAP1 | interactor | 7 | 0.667 | 2.408 | Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein |
179 |
NCOR1 | oncoprotein | 17 | 0.272 | 48.398 | BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region |
180 |
NEDD4L | suppressor | 23 | 0.390 | 67.882 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
181 |
NEDD8 | interactor | 22 | 0.505 | 24.156 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
182 |
NFATC4 | interactor | 2 | 1.000 | 0 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
183 |
NKD2 | interactor | 4 | 0.833 | 0.074 | PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
184 |
NOLC1 | interactor | 17 | 0.404 | 22.986 | DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2 |
185 |
NOS2 | interactor | 16 | 0.438 | 18.756 | FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain |
186 |
NPM1 | suppressor | 63 | 0.265 | 526.045 | Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
187 |
NSL1 | interactor | 1 | 0 | 0 | Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like |
188 |
NTRK1 | oncoprotein | 104 | 0.164 | 2243.711 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
189 |
NXF1 | interactor | 49 | 0.141 | 429.935 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
190 |
OBSL1 | protein found in more fusions | 36 | 0.341 | 117.023 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
191 |
OLA1 | interactor | 19 | 0.357 | 39.501 | Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933) |
192 |
OPTN | protein found in more fusions | 11 | 0.556 | 5.989 | ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
193 |
PABPC4 | interactor | 22 | 0.485 | 23.582 | ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family |
194 |
PAK1 | oncoprotein | 15 | 0.418 | 20.468 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
195 |
PAK2 | protein found in more fusions | 22 | 0.381 | 54.009 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
196 |
PAK4 | protein found in more fusions | 14 | 0.615 | 9.259 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
197 |
PARD3 | interactor | 17 | 0.434 | 39.659 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term |
198 |
PARD6A | interactor | 13 | 0.410 | 21.921 | PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
199 |
PCGF5 | interactor | 3 | 1.000 | 0 | DZR (PF12773, IPR025874): Double zinc ribbon zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2 |
200 |
PCNT | interactor | 6 | 0.400 | 3.832 | Caldesmon (PF02029, IPR006018): Caldesmon CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640) DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SlyX (PF04102, IPR007236): SlyX Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239) WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif FlxA (PF14282, IPR025577): FlxA-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
201 |
PFAS | interactor | 15 | 0.448 | 23.406 | AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain |
202 |
PGK1 | interactor | 25 | 0.447 | 43.392 | PGK (PF00162, IPR001576): Phosphoglycerate kinase |
203 |
PHB | suppressor | 27 | 0.422 | 49.629 | Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290) |
204 |
PHF3 | interactor | 1 | 0 | 0 | Mem_trans (PF03547, IPR004776): Membrane transport protein PHD (PF00628, IPR019787, SM00249): PHD-finger SPOC (PF07744, IPR012921): SPOC domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4724 (PF15852, IPR031711): Domain of unknown function (DUF4724) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR |
205 |
PIAS1 | suppressor | 11 | 0.400 | 16.320 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544 |
206 |
PNMA1 | oncoprotein | 5 | 0.600 | 2.317 | PNMA (PF14893, IPR026523): PNMA |
207 |
PNMA2 | interactor | 3 | 1.000 | 0 | PNMA (PF14893, IPR026523): PNMA |
208 |
POTEKP | interactor | 3 | 0.667 | 1.000 | NA |
209 |
PPFIBP1 | oncoprotein | 13 | 0.530 | 5.180 | DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837) |
210 |
PPP1R14A | interactor | 7 | 0.333 | 8.986 | PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor |
211 |
PRCC | oncoprotein | 5 | 0.600 | 0.626 | PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting |
212 |
PRDX2 | interactor | 16 | 0.342 | 26.628 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
213 |
PRKAA1 | suppressor | 18 | 0.314 | 44.500 | Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase |
214 |
PRKCA | interactor | 23 | 0.251 | 106.178 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
215 |
PRKCD | suppressor | 13 | 0.424 | 10.912 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
216 |
PRKCE | suppressor | 10 | 0.361 | 12.287 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
217 |
PRKCI | interactor | 16 | 0.392 | 35.535 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
218 |
PRKCZ | interactor | 21 | 0.368 | 55.699 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
219 |
PRKD1 | oncoprotein | 11 | 0.422 | 11.259 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
220 |
PRMT5 | protein found in more fusions | 21 | 0.247 | 51.652 | PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase |
221 |
PRPF18 | interactor | 1 | 0 | 0 | Prp18 (PF02840, IPR004098): Prp18 domain PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like |
222 |
PRR14L | interactor | 1 | 0 | 0 | Tantalus (PF15386, IPR028149): Drosophila Tantalus-like |
223 |
PSMA5 | oncoprotein | 18 | 0.340 | 20.277 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
224 |
PTPN14 | oncoprotein | 11 | 0.345 | 12.388 | FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
225 |
PTPRA | interactor | 4 | 0.500 | 0.855 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
226 |
PTPRO | interactor | 4 | 0.500 | 1.439 | CDC24 (PF06395, IPR010481): CDC24 Calponin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
227 |
RAB11FIP2 | protein found in more fusions | 7 | 0.933 | 0.250 | C2 (PF00168, IPR000008, SM00239): C2 domain RBD-FIP (PF09457, IPR019018): FIP domain |
228 |
RAD52 | oncoprotein | 6 | 0.500 | 0.805 | Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335) |
229 |
RAF1 | oncoprotein | 32 | 0.325 | 134.454 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
230 |
RAI14 | interactor | 9 | 0.583 | 6.202 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Fez1 (PF06818): Fez1 FliJ (PF02050, IPR012823): Flagellar FliJ protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_13 (PF13166, IPR026866): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
231 |
RALGPS2 | oncoprotein | 4 | 0.833 | 0.041 | PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain |
232 |
RAP1GAP2 | interactor | 3 | 1.000 | 0 | Rap_GAP (PF02145, IPR000331): Rap/ran-GAP |
233 |
RASAL3 | interactor | 2 | 1.000 | 0 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) |
234 |
RASSF2 | suppressor | 7 | 0.762 | 0.878 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
235 |
RBM26 | interactor | 5 | 0.900 | 0.154 | Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TT_ORF1 (PF02956, IPR004219): TT viral orf 1 zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif |
236 |
RBM27 | interactor | 1 | 0 | 0 | DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203) DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif |
237 |
REM1 | interactor | 4 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family AAA_33 (PF13671): AAA domain |
238 |
RFWD2 | suppressor | 13 | 0.439 | 14.298 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain |
239 |
RGS3 | oncoprotein | 4 | 0.833 | 0.133 | C2 (PF00168, IPR000008, SM00239): C2 domain CDC45 (PF02724, IPR003874): CDC45-like protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein |
240 |
RMDN3 | interactor | 5 | 0.700 | 0.956 | TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_16 (PF13432): Tetratricopeptide repeat |
241 |
RPL31 | interactor | 16 | 0.433 | 13.827 | Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e |
242 |
RPRD1A | interactor | 8 | 0.464 | 3.431 | CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour |
243 |
RPS6KA5 | interactor | 8 | 0.321 | 7.954 | Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
244 |
RRAD | interactor | 2 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family AAA_16 (PF13191): AAA ATPase domain |
245 |
SAMD4B | interactor | 6 | 0.667 | 0.791 | PHAT (PF09246, IPR015327): PHAT SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) |
246 |
SAMSN1 | interactor | 7 | 0.857 | 0.130 | SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein |
247 |
SAV1 | oncoprotein | 11 | 0.364 | 13.640 | WW (PF00397, IPR001202, SM00456): WW domain |
248 |
SDF4 | interactor | 9 | 0.306 | 15.219 | Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
249 |
SEC61A1 | interactor | 8 | 0.571 | 2.449 | DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430) SecY (PF00344, IPR002208): SecY translocase Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p |
250 |
SF3B1 | oncoprotein | 22 | 0.390 | 40.580 | Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
251 |
SFN | suppressor | 68 | 0.121 | 935.661 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
252 |
SGK1 | oncoprotein | 14 | 0.423 | 19.299 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain |
253 |
SH3GL1 | oncoprotein | 6 | 0.500 | 3.333 | BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
254 |
SHMT2 | interactor | 23 | 0.285 | 66.708 | SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase |
255 |
SIK1 | suppressor | 5 | 0.800 | 0.600 | Pkinase (PF00069, IPR000719): Protein kinase domain |
256 |
SIK2 | interactor | 12 | 0.500 | 8.402 | Pkinase (PF00069, IPR000719): Protein kinase domain |
257 |
SIK3 | oncoprotein | 9 | 0.639 | 2.854 | GET2 (PF08690, IPR028143): GET complex subunit GET2 Pkinase (PF00069, IPR000719): Protein kinase domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 |
258 |
SIMC1 | interactor | 3 | 0.667 | 0.400 | FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3 |
259 |
SLC9A3R1 | suppressor | 15 | 0.418 | 17.293 | EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
260 |
SLK | interactor | 4 | 0.833 | 0.041 | Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain Pkinase (PF00069, IPR000719): Protein kinase domain TMPIT (PF07851, IPR012926): TMPIT-like protein TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype) PKK (PF12474, IPR022165): Polo kinase kinase |
261 |
SMC1A | oncoprotein | 19 | 0.327 | 36.654 | SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain |
262 |
SNRNP40 | interactor | 11 | 0.473 | 6.646 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
263 |
SNRPD2P1 | interactor | 2 | 1.000 | 0 | NA |
264 |
SNRPE | interactor | 18 | 0.451 | 21.211 | LSM (PF01423, IPR001163): LSM domain |
265 |
SNRPF | interactor | 17 | 0.412 | 22.267 | LSM (PF01423, IPR001163): LSM domain |
266 |
SNX24 | interactor | 2 | 1.000 | 0 | PX (PF00787, IPR001683, SM00312): PX domain |
267 |
SORBS2 | oncoprotein | 13 | 0.485 | 9.290 | Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
268 |
SOX2 | oncoprotein | 19 | 0.203 | 56.547 | HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor |
269 |
SPIRE2 | interactor | 2 | 1.000 | 0 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA) FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger KIND (PF16474, IPR011019, SM00750): Kinase non-catalytic C-lobe domain |
270 |
SPRYD3 | interactor | 2 | 1.000 | 0 | Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein SPRY (PF00622, IPR003877, SM00449): SPRY domain |
271 |
SQSTM1 | oncoprotein | 33 | 0.244 | 180.266 | PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain |
272 |
SRSF8 | interactor | 4 | 0.500 | 0.277 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX (PF03105, IPR004331): SPX domain |
273 |
SSFA2 | interactor | 9 | 0.444 | 8.031 | KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus |
274 |
SSX2IP | interactor | 12 | 0.309 | 13.936 | ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein |
275 |
STAC | interactor | 3 | 0.667 | 0.333 | SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2 |
276 |
STAU1 | protein found in more fusions | 32 | 0.333 | 96.674 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
277 |
STK38 | interactor | 10 | 0.389 | 7.793 | MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
278 |
SYN2 | interactor | 3 | 1.000 | 0 | LpxD (PF04613, IPR020573): UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD SPX (PF03105, IPR004331): SPX domain Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain Synapsin_N (PF10581, IPR019736): Synapsin N-terminal DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain |
279 |
SYNPO | interactor | 11 | 0.455 | 11.333 | Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) |
280 |
SYNPO2 | suppressor | 5 | 0.800 | 0.239 | Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
281 |
TAB2 | oncoprotein | 14 | 0.474 | 16.860 | CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others |
282 |
TBC1D4 | interactor | 10 | 0.578 | 2.713 | DUF632 (PF04782, IPR006867): Protein of unknown function (DUF632) PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) RecR (PF02132, IPR023628): RecR protein RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350) UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 DUF4806 (PF16064, IPR032071): Domain of unknown function (DUF4806) |
283 |
TBXA2R | interactor | 5 | 0.500 | 0.905 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
284 |
TCEB3 | suppressor | 8 | 0.393 | 6.016 | Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain |
285 |
TERT | oncoprotein | 8 | 0.607 | 2.404 | RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain |
286 |
TESPA1 | interactor | 3 | 1.000 | 0 | PUB (PF09409, IPR018997): PUB domain DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain |
287 |
TGM2 | protein found in more fusions | 22 | 0.329 | 60.969 | Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily |
288 |
TIMM13 | interactor | 8 | 0.393 | 10.465 | zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger |
289 |
TJP2 | oncoprotein | 10 | 0.556 | 4.106 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
290 |
TNFAIP3 | suppressor | 13 | 0.455 | 10.531 | OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain |
291 |
TNK1 | suppressor | 9 | 0.750 | 0.636 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase |
292 |
TNS1 | interactor | 2 | 1.000 | 0 | Protocadherin (PF08374, IPR013585): Protocadherin PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
293 |
TP53 | suppressor | 71 | 0.160 | 987.201 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
294 |
TP53BP1 | suppressor | 18 | 0.405 | 30.830 | 53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
295 |
TP53BP2 | suppressor | 15 | 0.467 | 20.258 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
296 |
TPH1 | interactor | 2 | 1.000 | 0 | ACT (PF01842, IPR002912): ACT domain Biopterin_H (PF00351, IPR019774): Biopterin-dependent aromatic amino acid hydroxylase |
297 |
TRA2B | interactor | 17 | 0.551 | 16.673 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
298 |
TRIM21 | interactor | 17 | 0.425 | 21.617 | DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
299 |
TRIM32 | suppressor | 15 | 0.582 | 9.301 | NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
300 |
TSC1 | suppressor | 11 | 0.533 | 6.187 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein |
301 |
TSC2 | suppressor | 12 | 0.576 | 9.642 | Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 |
302 |
TUBA3C | interactor | 8 | 0.893 | 0.243 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
303 |
TUBB | interactor | 42 | 0.307 | 177.176 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
304 |
TUBG1 | protein found in more fusions | 22 | 0.290 | 65.163 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
305 |
U2AF2 | protein found in more fusions | 32 | 0.428 | 66.385 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
306 |
UBC | protein found in more fusions | 63 | 0.221 | 615.002 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
307 |
UBE2V1 | interactor | 10 | 0.644 | 4.183 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
308 |
UBE3A | oncoprotein | 16 | 0.362 | 32.710 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A |
309 |
UCHL5 | oncoprotein | 16 | 0.352 | 35.229 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 |
310 |
UCP2 | interactor | 3 | 1.000 | 0 | Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein |
311 |
UCP3 | interactor | 3 | 1.000 | 0 | Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein |
312 |
UHRF1BP1L | oncoprotein | 3 | 0.667 | 0.100 | Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13 VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal |
313 |
UNK | interactor | 21 | 0.290 | 56.846 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
314 |
USP8 | interactor | 13 | 0.727 | 2.663 | DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain SET (PF00856, IPR001214, SM00317): SET domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain |
315 |
VCAM1 | interactor | 32 | 0.339 | 66.534 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
316 |
VCL | oncoprotein | 29 | 0.365 | 91.041 | Vinculin (PF01044, IPR006077): Vinculin family |
317 |
VCP | protein found in more fusions | 63 | 0.272 | 513.943 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
318 |
VIM | suppressor | 31 | 0.349 | 86.944 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region |
319 |
WDR62 | interactor | 10 | 0.556 | 6.362 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
320 |
WNK1 | interactor | 15 | 0.527 | 18.041 | SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal |
321 |
WNK2 | suppressor | 3 | 1.000 | 0 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal |
322 |
WWOX | suppressor | 22 | 0.169 | 102.123 | adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain |
323 |
WWTR1 | interactor | 7 | 0.762 | 0.973 | WW (PF00397, IPR001202, SM00456): WW domain |
324 |
XPO1 | interactor | 80 | 0.128 | 1538.512 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
325 |
XRCC6 | oncoprotein | 36 | 0.284 | 151.753 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain |
326 |
YAP1 | suppressor | 25 | 0.307 | 80.169 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
327 |
YWHAB | interactor | 132 | 0.096 | 4025.562 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
328 |
YWHAE | oncoprotein | 149 | 0.100 | 5470.830 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
329 |
YWHAG | protein found in more fusions | 133 | 0.105 | 3976.240 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
330 |
YWHAH | protein found in more fusions | 88 | 0.144 | 1409.979 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
331 |
YWHAQ | interactor | 137 | 0.107 | 4172.940 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
332 |
ZAK | protein found in more fusions | 8 | 0.429 | 4.899 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) |
333 |
ZFYVE19 | interactor | 7 | 0.571 | 2.958 | Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger |
334 |
ZHX2 | suppressor | 3 | 0.667 | 0.069 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain DUF4343 (PF14243, IPR025643): Domain of unknown function (DUF4343) |
335 |
ZNF839 | interactor | 3 | 0.667 | 0.061 | DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764) |