Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins YWHAZ (from a repository: Wed Nov 16 23:49:44 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 335 The number (and %) of the onco-proteins 110 (32.84 %) The number (and %) of the tumor suppressors 50 (14.93 %) Total number of binary PPIs (saturation %) 3219 (5.75 %) The number (and %) of affected PPIs 335 (10.41 %) The number of possible different fusions 72 PPI diameter 2 PPI radius 1 The average degree of PPI 18.418 Assortativity coefficient -0.2395 The network average Clustering coefficient 0.486 The number (and %) of a zero Clustering coefficients 16 (4.78 %) The number (and %) of a zero Betweenness Centrality 46 (13.73 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: YWHAZ	All fusions
Proteins found in more fusions	GRK5 (see 3 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); COPB1 (see 2 fusions); GRB2 (see 1 fusions); SLC9A3R1 (see 2 fusions); YWHAH (see 2 fusions); MDM4 (see 2 fusions); OPTN (see 1 fusions); EWSR1 (see 2 fusions); PIAS1 (see 2 fusions); YWHAZ (see 1 fusions); SORBS2 (see 4 fusions); MARK3 (see 1 fusions); RAB11FIP2 (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); FAN1 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); APP (see 4 fusions); VCP (see 4 fusions); PRMT5 (see 2 fusions); HUWE1 (see 2 fusions); HDAC4 (see 1 fusions); MARK2 (see 2 fusions); PAK4 (see 1 fusions); NEDD4L (see 3 fusions); BAG3 (see 4 fusions); KAT8 (see 1 fusions); HSPB1 (see 3 fusions); ECHS1 (see 1 fusions); ZAK (see 2 fusions); TGM2 (see 4 fusions); ATP5A1 (see 1 fusions); PRKCE (see 3 fusions); ERRFI1 (see 1 fusions); TUBG1 (see 1 fusions); PPFIBP1 (see 1 fusions); STAU1 (see 2 fusions); MAP3K2 (see 2 fusions); CBL (see 1 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); PRKCD (see 2 fusions); CUL3 (see 1 fusions); MAPRE1 (see 1 fusions); KIF11 (see 1 fusions); VCL (see 2 fusions); COPS5 (see 1 fusions); FN1/YWHAG (see 1 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); LRRK2 (see 1 fusions); MTOR (see 1 fusions); LIMK1 (see 1 fusions); TP53 (see 3 fusions); TAB2 (see 1 fusions); YWHAG (see 1 fusions); FOXO1 (see 1 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); ATP5A1/HUWE1 (see 2 fusions); HNRNPL (see 2 fusions); MAPT (see 1 fusions); EDC3 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); BRAF (see 3 fusions); G6PD (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	YWHAZ	parental protein	335	0.049	63934.846	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
2	AANAT	interactor	1	0	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
3	ABL1	oncoprotein	32	0.385	84.518	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4	ADORA3	interactor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5	AJUBA	oncoprotein	7	0.429	5.029	LIM (PF00412, IPR001781, SM00132): LIM domain
6	AKT1	oncoprotein	41	0.208	270.554	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
7	AKT1S1	interactor	10	0.444	6.143	Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
8	AP3B1	interactor	7	0.333	3.419	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
9	APP	protein found in more fusions	72	0.096	1458.099	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10	ARAF	oncoprotein	15	0.562	16.886	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11	ARHGEF2	oncoprotein	15	0.495	12.858	IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12	ARRB1	interactor	27	0.308	98.105	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
13	ATG9A	interactor	3	1.000	0	APG9 (PF04109, IPR007241): Autophagy protein Apg9 PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
14	ATP5A1	protein found in more fusions	35	0.431	63.344	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
15	B4GALT7	interactor	1	0	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
16	BAD	oncoprotein	20	0.389	54.740	Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
17	BAG3	oncoprotein	29	0.249	137.683	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
18	BARD1	suppressor	22	0.310	59.045	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
19	BCAR1	oncoprotein	9	0.528	9.283	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
20	BDP1	interactor	1	0	0	SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DUF2917 (PF11142, IPR021317): Protein of unknown function (DUF2917) UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542 Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
21	BRAF	oncoprotein	17	0.583	18.226	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
22	BRCA1	suppressor	35	0.251	185.981	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
23	BRD4	oncoprotein	8	0.643	3.737	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
24	BTRC	oncoprotein	30	0.298	111.770	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
25	CAPNS1	interactor	14	0.516	11.753	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
26	CBL	suppressor	28	0.362	80.205	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
27	CBX4	oncoprotein	8	0.619	2.552	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region CBX7_C (PF17218): CBX family C-terminal motif
28	CCDC84	interactor	1	0	0	CCDC84 (PF14968, IPR028015): Coiled coil protein 84
29	CDC25A	oncoprotein	16	0.525	11.662	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
30	CDC25B	oncoprotein	13	0.577	8.265	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
31	CDC25C	oncoprotein	11	0.655	3.654	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
32	CDC5L	interactor	46	0.252	337.259	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
33	CDCA7	interactor	5	0.600	0.346	zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1 Imm51 (PF15595, IPR028956): Immunity protein 51
34	CDK11B	oncoprotein	9	0.714	2.660	DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
35	CDK16	oncoprotein	10	0.644	1.948	Pkinase (PF00069, IPR000719): Protein kinase domain
36	CDK2	suppressor	54	0.235	425.854	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
37	CDKN1B	suppressor	20	0.395	37.528	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
38	CENPJ	interactor	16	0.267	45.489	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
39	CEP126	interactor	2	1.000	0	Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa) K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
40	CGNL1	interactor	3	1.000	0	Abhydrolase_4 (PF08386, IPR013595): TAP-like protein Myosin_tail_1 (PF01576, IPR002928): Myosin tail
41	CHAF1A	interactor	12	0.455	7.038	CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
42	CLK3	interactor	11	0.356	6.662	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
43	COPB1	protein found in more fusions	20	0.404	21.199	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
44	COPS5	protein found in more fusions	57	0.253	433.755	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
45	COPS7B	interactor	11	0.600	7.963	PCI (PF01399, IPR000717, SM00088): PCI domain
46	CRY1	interactor	18	0.434	17.003	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
47	CSF2RB	interactor	2	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Tissue_fac (PF01108, IPR003961): Tissue factor
48	CSNK1D	interactor	9	0.333	10.638	Pkinase (PF00069, IPR000719): Protein kinase domain
49	CTNNB1	oncoprotein	40	0.249	202.920	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
50	CUL1	suppressor	48	0.302	220.433	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
51	CUL2	suppressor	35	0.303	133.673	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
52	CUL3	protein found in more fusions	64	0.249	557.774	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
53	CUL7	protein found in more fusions	43	0.292	188.860	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
54	CWC27	interactor	2	1.000	0	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
55	CYFIP1	interactor	5	0.600	1.225	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
56	CYFIP2	interactor	8	0.607	3.467	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger
57	DCAF7	interactor	14	0.495	12.700	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
58	DDIT4	interactor	4	0.667	0.237	RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
59	DFFA	suppressor	12	0.455	9.796	CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
60	DISC1	interactor	8	0.643	6.509	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
61	DMTN	interactor	8	0.464	2.866	VHP (PF02209, IPR003128, SM00153): Villin headpiece domain AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
62	DNAJB4	suppressor	6	0.600	1.462	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
63	DOCK7	interactor	16	0.400	19.359	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
64	DTL	interactor	10	0.600	2.354	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
65	ECHS1	protein found in more fusions	14	0.385	18.230	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
66	ECT2	suppressor	11	0.327	15.836	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
67	EDC3	protein found in more fusions	7	0.867	0.096	FDF (PF09532, IPR019050, SM01199): FDF domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus LSM14 (PF12701, IPR025609): Scd6-like Sm domain Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3 DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
68	EFNB3	interactor	1	0	0	Ephrin (PF00812, IPR001799): Ephrin
69	EGFR	oncoprotein	56	0.193	590.944	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
70	EIF3A	oncoprotein	18	0.320	30.419	DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
71	EIF4B	interactor	15	0.484	11.102	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3774 (PF12609, IPR022251): Wound-induced protein PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
72	EIF5	interactor	18	0.595	15.336	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
73	ENO1	oncoprotein	39	0.294	184.460	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
74	EP300	oncoprotein	42	0.174	390.887	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
75	EPB41L2	interactor	7	0.714	1.378	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain SAB (PF04382, IPR007477): SAB domain TCP (PF03634, IPR005333): TCP family transcription factor
76	EPB41L3	suppressor	15	0.467	29.274	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain
77	ERP44	interactor	14	0.385	27.672	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
78	ERRFI1	suppressor	10	0.611	7.697	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
79	EWSR1	oncoprotein	43	0.245	296.132	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
80	EXO1	interactor	7	0.857	0.130	XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
81	FAM13B	interactor	4	1.000	0	COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MazG (PF03819, IPR004518): MazG nucleotide pyrophosphohydrolase domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Drc1-Sld2 (PF11719, IPR021110): DNA replication and checkpoint protein GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
82	FAM189A2	interactor	8	0.500	5.948	CD20 (PF04103, IPR007237): CD20-like family
83	FAM53C	interactor	5	0.800	0.128	FAM53 (PF15242, IPR029356): Family of FAM53
84	FAM65B	interactor	3	0.667	0.167	Glu-tRNAGln (PF02686, IPR003837): Glu-tRNAGln amidotransferase C subunit HEAT_2 (PF13646): HEAT repeats PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
85	FAN1	protein found in more fusions	4	0.667	0.056	VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TPR_12 (PF13424): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
86	FBXO6	interactor	35	0.254	154.253	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
87	FBXW11	interactor	37	0.259	185.626	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
88	FERMT2	interactor	17	0.449	26.740	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
89	FHOD1	interactor	7	0.733	0.939	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
90	FN1	oncoprotein	49	0.269	253.733	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
91	FOXO1	suppressor	9	0.464	4.475	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
92	FOXO3	suppressor	16	0.442	17.900	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
93	FUS	suppressor	37	0.428	102.356	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
94	G6PD	protein found in more fusions	24	0.522	40.889	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
95	GABARAPL2	interactor	12	0.288	23.167	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
96	GCH1	interactor	3	1.000	0	GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
97	GINS4	interactor	3	0.667	0.400	Sld5 (PF05916, IPR021151): GINS complex protein SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
98	GP1BA	interactor	1	0	0	LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
99	GP1BB	interactor	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
100	GRB2	oncoprotein	47	0.277	345.748	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
101	GRK5	protein found in more fusions	19	0.242	64.540	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
102	H2AFX	suppressor	25	0.403	58.321	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
103	HDAC4	oncoprotein	19	0.451	37.361	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
104	HDAC5	protein found in more fusions	43	0.274	245.311	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
105	HDAC6	oncoprotein	26	0.293	89.037	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
106	HDAC7	protein found in more fusions	20	0.433	32.713	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
107	HDAC9	interactor	9	0.536	4.207	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein
108	HIST1H3A	interactor	27	0.338	92.051	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
109	HIST1H4A	interactor	28	0.307	95.258	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
110	HIVEP2	interactor	6	0.800	0.363	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
111	HMGN1	interactor	4	1.000	0	HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
112	HNF1A	oncoprotein	8	0.667	0.955	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
113	HNRNPA1	interactor	51	0.337	232.650	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
114	HNRNPL	protein found in more fusions	22	0.490	14.978	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
115	HS6ST2	interactor	1	0	0	Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family Clr2 (PF10383, IPR018839): Transcription-silencing protein Clr2
116	HSPA1B	interactor	20	0.358	24.050	HSP70 (PF00012, IPR013126): Hsp70 protein
117	HSPB1	oncoprotein	51	0.259	372.072	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
118	HUWE1	oncoprotein	44	0.297	214.643	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
119	IL9R	interactor	1	0	0	NA
120	ING1	suppressor	10	0.622	1.676	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
121	INPP5A	interactor	1	0	0	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family Glyco_hydro_cc (PF11790, IPR024655): Glycosyl hydrolase catalytic core
122	IRS2	oncoprotein	12	0.727	2.003	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
123	IRS4	interactor	20	0.516	18.914	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
124	ISOC1	interactor	13	0.718	6.115	Isochorismatase (PF00857, IPR000868): Isochorismatase family Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
125	ITGA4	interactor	36	0.376	83.147	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
126	ITGB2	interactor	7	0.429	4.422	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
127	KAT8	protein found in more fusions	11	0.600	7.411	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
128	KIAA0232	interactor	2	1.000	0	DUF4603 (PF15376, IPR027871): Domain of unknown function (DUF4603)
129	KIAA0930	interactor	8	0.750	0.489	DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045)
130	KIF11	protein found in more fusions	14	0.333	28.819	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
131	KIF1C	interactor	8	0.714	2.820	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
132	KIF23	interactor	15	0.390	23.083	DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
133	KIF5B	interactor	20	0.442	31.513	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
134	KLC1	interactor	15	0.448	26.394	Gly_radical (PF01228, IPR001150): Glycine radical SOGA (PF11365, IPR027881): Protein SOGA TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
135	KLC4	interactor	10	0.778	2.542	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat LUD_dom (PF02589): LUD domain
136	KLF11	interactor	3	0.667	1.000	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
137	KLHL7	interactor	6	0.900	0.053	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_6 (PF13964): Kelch motif
138	LARP1	interactor	20	0.437	35.582	La (PF05383, IPR006630, SM00715): La domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
139	LCA5	interactor	11	0.509	12.856	IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
140	LCP2	interactor	5	0.800	0.389	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain
141	LDHB	interactor	30	0.369	106.514	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
142	LIMK1	oncoprotein	9	0.393	6.779	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
143	LRMP	suppressor	2	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 MRVI1 (PF05781, IPR008677): MRVI1 protein DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203) EF-hand_9 (PF14658): EF-hand domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
144	LRRK2	oncoprotein	15	0.516	18.430	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
145	LYST	interactor	5	0.800	0.650	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4800 (PF16057): Domain of unknown function (DUF4800)
146	MADD	suppressor	6	0.467	3.640	DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus uDENN (PF03456, IPR005113, SM00800): uDENN domain
147	MAP2K1	oncoprotein	13	0.530	14.663	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
148	MAP2K5	oncoprotein	12	0.364	22.264	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
149	MAP3K2	protein found in more fusions	14	0.449	18.205	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
150	MAP3K4	suppressor	6	0.500	3.150	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pkinase (PF00069, IPR000719): Protein kinase domain PLU-1 (PF08429, IPR013637): PLU-1-like protein Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
151	MAP3K5	oncoprotein	11	0.467	7.376	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
152	MAPK7	oncoprotein	20	0.398	37.444	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
153	MAPK8	oncoprotein	24	0.209	114.600	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
154	MAPKAPK2	oncoprotein	11	0.444	10.094	Pkinase (PF00069, IPR000719): Protein kinase domain
155	MAPRE1	oncoprotein	25	0.275	89.705	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
156	MAPT	protein found in more fusions	22	0.310	63.474	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
157	MARK1	interactor	7	0.619	1.431	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
158	MARK2	protein found in more fusions	26	0.410	70.805	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
159	MARK3	protein found in more fusions	16	0.705	7.294	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
160	MAST1	interactor	7	0.619	1.479	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain
161	MCM2	oncoprotein	56	0.325	300.571	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
162	MDC1	suppressor	19	0.357	54.606	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
163	MDM4	oncoprotein	15	0.516	8.646	zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
164	MEF2C	oncoprotein	8	0.393	5.756	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
165	MEPCE	interactor	14	0.319	32.376	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
166	MEX3B	interactor	5	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
167	MGMT	interactor	10	0.533	5.160	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
168	MOV10	interactor	48	0.145	447.649	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
169	MPHOSPH9	interactor	4	0.833	0.182	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus IL15 (PF02372, IPR003443): Interleukin 15 Tup_N (PF08581, IPR013890): Tup N-terminal KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
170	MSL2	interactor	6	0.733	0.855	MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2 zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
171	MST1R	suppressor	10	0.778	1.048	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain
172	MTOR	oncoprotein	23	0.286	68.792	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
173	MYCBP2	interactor	11	0.509	9.358	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHR (PF08005, IPR012983): PHR domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SH3_3 (PF08239, IPR003646): Bacterial SH3 domain XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
174	MYH9	suppressor	29	0.283	126.463	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
175	NADK	interactor	7	0.762	0.641	NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
176	NBEAL2	interactor	2	1.000	0	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704) DUF4800 (PF16057): Domain of unknown function (DUF4800)
177	NCAPD3	interactor	7	0.429	3.426	DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013) CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
178	NCKAP1	interactor	7	0.667	2.408	Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
179	NCOR1	oncoprotein	17	0.272	48.398	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
180	NEDD4L	suppressor	23	0.390	67.882	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
181	NEDD8	interactor	22	0.505	24.156	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
182	NFATC4	interactor	2	1.000	0	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
183	NKD2	interactor	4	0.833	0.074	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
184	NOLC1	interactor	17	0.404	22.986	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
185	NOS2	interactor	16	0.438	18.756	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
186	NPM1	suppressor	63	0.265	526.045	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
187	NSL1	interactor	1	0	0	Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
188	NTRK1	oncoprotein	104	0.164	2243.711	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
189	NXF1	interactor	49	0.141	429.935	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
190	OBSL1	protein found in more fusions	36	0.341	117.023	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
191	OLA1	interactor	19	0.357	39.501	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
192	OPTN	protein found in more fusions	11	0.556	5.989	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
193	PABPC4	interactor	22	0.485	23.582	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
194	PAK1	oncoprotein	15	0.418	20.468	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
195	PAK2	protein found in more fusions	22	0.381	54.009	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
196	PAK4	protein found in more fusions	14	0.615	9.259	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
197	PARD3	interactor	17	0.434	39.659	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
198	PARD6A	interactor	13	0.410	21.921	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
199	PCGF5	interactor	3	1.000	0	DZR (PF12773, IPR025874): Double zinc ribbon zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
200	PCNT	interactor	6	0.400	3.832	Caldesmon (PF02029, IPR006018): Caldesmon CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640) DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SlyX (PF04102, IPR007236): SlyX Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239) WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif FlxA (PF14282, IPR025577): FlxA-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
201	PFAS	interactor	15	0.448	23.406	AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
202	PGK1	interactor	25	0.447	43.392	PGK (PF00162, IPR001576): Phosphoglycerate kinase
203	PHB	suppressor	27	0.422	49.629	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
204	PHF3	interactor	1	0	0	Mem_trans (PF03547, IPR004776): Membrane transport protein PHD (PF00628, IPR019787, SM00249): PHD-finger SPOC (PF07744, IPR012921): SPOC domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4724 (PF15852, IPR031711): Domain of unknown function (DUF4724) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
205	PIAS1	suppressor	11	0.400	16.320	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
206	PNMA1	oncoprotein	5	0.600	2.317	PNMA (PF14893, IPR026523): PNMA
207	PNMA2	interactor	3	1.000	0	PNMA (PF14893, IPR026523): PNMA
208	POTEKP	interactor	3	0.667	1.000	NA
209	PPFIBP1	oncoprotein	13	0.530	5.180	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
210	PPP1R14A	interactor	7	0.333	8.986	PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
211	PRCC	oncoprotein	5	0.600	0.626	PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
212	PRDX2	interactor	16	0.342	26.628	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
213	PRKAA1	suppressor	18	0.314	44.500	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
214	PRKCA	interactor	23	0.251	106.178	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
215	PRKCD	suppressor	13	0.424	10.912	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
216	PRKCE	suppressor	10	0.361	12.287	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
217	PRKCI	interactor	16	0.392	35.535	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
218	PRKCZ	interactor	21	0.368	55.699	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
219	PRKD1	oncoprotein	11	0.422	11.259	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
220	PRMT5	protein found in more fusions	21	0.247	51.652	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
221	PRPF18	interactor	1	0	0	Prp18 (PF02840, IPR004098): Prp18 domain PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
222	PRR14L	interactor	1	0	0	Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
223	PSMA5	oncoprotein	18	0.340	20.277	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
224	PTPN14	oncoprotein	11	0.345	12.388	FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
225	PTPRA	interactor	4	0.500	0.855	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
226	PTPRO	interactor	4	0.500	1.439	CDC24 (PF06395, IPR010481): CDC24 Calponin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
227	RAB11FIP2	protein found in more fusions	7	0.933	0.250	C2 (PF00168, IPR000008, SM00239): C2 domain RBD-FIP (PF09457, IPR019018): FIP domain
228	RAD52	oncoprotein	6	0.500	0.805	Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
229	RAF1	oncoprotein	32	0.325	134.454	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
230	RAI14	interactor	9	0.583	6.202	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Fez1 (PF06818): Fez1 FliJ (PF02050, IPR012823): Flagellar FliJ protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_13 (PF13166, IPR026866): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
231	RALGPS2	oncoprotein	4	0.833	0.041	PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
232	RAP1GAP2	interactor	3	1.000	0	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
233	RASAL3	interactor	2	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
234	RASSF2	suppressor	7	0.762	0.878	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
235	RBM26	interactor	5	0.900	0.154	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TT_ORF1 (PF02956, IPR004219): TT viral orf 1 zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
236	RBM27	interactor	1	0	0	DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit PWI (PF01480, IPR002483, SM00311): PWI domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203) DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
237	REM1	interactor	4	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family AAA_33 (PF13671): AAA domain
238	RFWD2	suppressor	13	0.439	14.298	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain
239	RGS3	oncoprotein	4	0.833	0.133	C2 (PF00168, IPR000008, SM00239): C2 domain CDC45 (PF02724, IPR003874): CDC45-like protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
240	RMDN3	interactor	5	0.700	0.956	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_16 (PF13432): Tetratricopeptide repeat
241	RPL31	interactor	16	0.433	13.827	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
242	RPRD1A	interactor	8	0.464	3.431	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
243	RPS6KA5	interactor	8	0.321	7.954	Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
244	RRAD	interactor	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family AAA_16 (PF13191): AAA ATPase domain
245	SAMD4B	interactor	6	0.667	0.791	PHAT (PF09246, IPR015327): PHAT SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
246	SAMSN1	interactor	7	0.857	0.130	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
247	SAV1	oncoprotein	11	0.364	13.640	WW (PF00397, IPR001202, SM00456): WW domain
248	SDF4	interactor	9	0.306	15.219	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
249	SEC61A1	interactor	8	0.571	2.449	DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430) SecY (PF00344, IPR002208): SecY translocase Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
250	SF3B1	oncoprotein	22	0.390	40.580	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
251	SFN	suppressor	68	0.121	935.661	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
252	SGK1	oncoprotein	14	0.423	19.299	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
253	SH3GL1	oncoprotein	6	0.500	3.333	BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
254	SHMT2	interactor	23	0.285	66.708	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
255	SIK1	suppressor	5	0.800	0.600	Pkinase (PF00069, IPR000719): Protein kinase domain
256	SIK2	interactor	12	0.500	8.402	Pkinase (PF00069, IPR000719): Protein kinase domain
257	SIK3	oncoprotein	9	0.639	2.854	GET2 (PF08690, IPR028143): GET complex subunit GET2 Pkinase (PF00069, IPR000719): Protein kinase domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
258	SIMC1	interactor	3	0.667	0.400	FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
259	SLC9A3R1	suppressor	15	0.418	17.293	EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
260	SLK	interactor	4	0.833	0.041	Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain Pkinase (PF00069, IPR000719): Protein kinase domain TMPIT (PF07851, IPR012926): TMPIT-like protein TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype) PKK (PF12474, IPR022165): Polo kinase kinase
261	SMC1A	oncoprotein	19	0.327	36.654	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
262	SNRNP40	interactor	11	0.473	6.646	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
263	SNRPD2P1	interactor	2	1.000	0	NA
264	SNRPE	interactor	18	0.451	21.211	LSM (PF01423, IPR001163): LSM domain
265	SNRPF	interactor	17	0.412	22.267	LSM (PF01423, IPR001163): LSM domain
266	SNX24	interactor	2	1.000	0	PX (PF00787, IPR001683, SM00312): PX domain
267	SORBS2	oncoprotein	13	0.485	9.290	Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
268	SOX2	oncoprotein	19	0.203	56.547	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
269	SPIRE2	interactor	2	1.000	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA) FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger KIND (PF16474, IPR011019, SM00750): Kinase non-catalytic C-lobe domain
270	SPRYD3	interactor	2	1.000	0	Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein SPRY (PF00622, IPR003877, SM00449): SPRY domain
271	SQSTM1	oncoprotein	33	0.244	180.266	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
272	SRSF8	interactor	4	0.500	0.277	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX (PF03105, IPR004331): SPX domain
273	SSFA2	interactor	9	0.444	8.031	KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
274	SSX2IP	interactor	12	0.309	13.936	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
275	STAC	interactor	3	0.667	0.333	SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
276	STAU1	protein found in more fusions	32	0.333	96.674	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
277	STK38	interactor	10	0.389	7.793	MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
278	SYN2	interactor	3	1.000	0	LpxD (PF04613, IPR020573): UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD SPX (PF03105, IPR004331): SPX domain Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain Synapsin_N (PF10581, IPR019736): Synapsin N-terminal DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
279	SYNPO	interactor	11	0.455	11.333	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
280	SYNPO2	suppressor	5	0.800	0.239	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
281	TAB2	oncoprotein	14	0.474	16.860	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
282	TBC1D4	interactor	10	0.578	2.713	DUF632 (PF04782, IPR006867): Protein of unknown function (DUF632) PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) RecR (PF02132, IPR023628): RecR protein RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350) UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 DUF4806 (PF16064, IPR032071): Domain of unknown function (DUF4806)
283	TBXA2R	interactor	5	0.500	0.905	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
284	TCEB3	suppressor	8	0.393	6.016	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
285	TERT	oncoprotein	8	0.607	2.404	RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
286	TESPA1	interactor	3	1.000	0	PUB (PF09409, IPR018997): PUB domain DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain
287	TGM2	protein found in more fusions	22	0.329	60.969	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
288	TIMM13	interactor	8	0.393	10.465	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
289	TJP2	oncoprotein	10	0.556	4.106	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
290	TNFAIP3	suppressor	13	0.455	10.531	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
291	TNK1	suppressor	9	0.750	0.636	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
292	TNS1	interactor	2	1.000	0	Protocadherin (PF08374, IPR013585): Protocadherin PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
293	TP53	suppressor	71	0.160	987.201	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
294	TP53BP1	suppressor	18	0.405	30.830	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
295	TP53BP2	suppressor	15	0.467	20.258	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
296	TPH1	interactor	2	1.000	0	ACT (PF01842, IPR002912): ACT domain Biopterin_H (PF00351, IPR019774): Biopterin-dependent aromatic amino acid hydroxylase
297	TRA2B	interactor	17	0.551	16.673	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
298	TRIM21	interactor	17	0.425	21.617	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
299	TRIM32	suppressor	15	0.582	9.301	NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
300	TSC1	suppressor	11	0.533	6.187	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
301	TSC2	suppressor	12	0.576	9.642	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
302	TUBA3C	interactor	8	0.893	0.243	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
303	TUBB	interactor	42	0.307	177.176	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
304	TUBG1	protein found in more fusions	22	0.290	65.163	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
305	U2AF2	protein found in more fusions	32	0.428	66.385	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
306	UBC	protein found in more fusions	63	0.221	615.002	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
307	UBE2V1	interactor	10	0.644	4.183	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
308	UBE3A	oncoprotein	16	0.362	32.710	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
309	UCHL5	oncoprotein	16	0.352	35.229	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
310	UCP2	interactor	3	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
311	UCP3	interactor	3	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
312	UHRF1BP1L	oncoprotein	3	0.667	0.100	Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13 VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
313	UNK	interactor	21	0.290	56.846	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
314	USP8	interactor	13	0.727	2.663	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain SET (PF00856, IPR001214, SM00317): SET domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
315	VCAM1	interactor	32	0.339	66.534	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
316	VCL	oncoprotein	29	0.365	91.041	Vinculin (PF01044, IPR006077): Vinculin family
317	VCP	protein found in more fusions	63	0.272	513.943	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
318	VIM	suppressor	31	0.349	86.944	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
319	WDR62	interactor	10	0.556	6.362	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
320	WNK1	interactor	15	0.527	18.041	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
321	WNK2	suppressor	3	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
322	WWOX	suppressor	22	0.169	102.123	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
323	WWTR1	interactor	7	0.762	0.973	WW (PF00397, IPR001202, SM00456): WW domain
324	XPO1	interactor	80	0.128	1538.512	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
325	XRCC6	oncoprotein	36	0.284	151.753	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
326	YAP1	suppressor	25	0.307	80.169	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
327	YWHAB	interactor	132	0.096	4025.562	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
328	YWHAE	oncoprotein	149	0.100	5470.830	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
329	YWHAG	protein found in more fusions	133	0.105	3976.240	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
330	YWHAH	protein found in more fusions	88	0.144	1409.979	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
331	YWHAQ	interactor	137	0.107	4172.940	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
332	ZAK	protein found in more fusions	8	0.429	4.899	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
333	ZFYVE19	interactor	7	0.571	2.958	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
334	ZHX2	suppressor	3	0.667	0.069	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain DUF4343 (PF14243, IPR025643): Domain of unknown function (DUF4343)
335	ZNF839	interactor	3	0.667	0.061	DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764)

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