1 |
YWHAH | parental protein | 180 | 0.063 | 18760.774 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
2 |
ABCA2 | interactor | 1 | 0 | 0 | ABC_tran (PF00005, IPR003439): ABC transporter ABC2_membrane_3 (PF12698): ABC-2 family transporter protein AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162) |
3 |
ABCE1 | interactor | 12 | 0.327 | 14.554 | ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain |
4 |
ABL1 | oncoprotein | 19 | 0.542 | 22.322 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
5 |
ALDH7A1 | interactor | 12 | 0.561 | 11.197 | Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family |
6 |
ARAF | oncoprotein | 10 | 0.844 | 1.356 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
7 |
ARHGEF2 | oncoprotein | 14 | 0.582 | 16.559 | IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
8 |
ARRB1 | interactor | 11 | 0.764 | 2.309 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
9 |
ARRB2 | interactor | 17 | 0.515 | 28.577 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
10 |
BAD | oncoprotein | 12 | 0.697 | 6.264 | Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD |
11 |
BAG3 | oncoprotein | 14 | 0.564 | 13.208 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
12 |
BRAF | oncoprotein | 14 | 0.654 | 11.728 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
13 |
C10orf2 | interactor | 1 | 0 | 0 | T2SSE (PF00437, IPR001482): Type II/IV secretion system protein SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain AAA_25 (PF13481): AAA domain |
14 |
CAPNS1 | interactor | 19 | 0.474 | 32.854 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
15 |
CBL | suppressor | 15 | 0.604 | 15.286 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
16 |
CC2D2A | interactor | 1 | 0 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240) SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain |
17 |
CCDC8 | interactor | 22 | 0.352 | 69.706 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
18 |
CCDC88A | protein found in more fusions | 10 | 0.417 | 9.849 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) HOOK (PF05622, IPR008636): HOOK protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 KxDL (PF10241, IPR019371): Uncharacterized conserved protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain |
19 |
CDC25B | oncoprotein | 8 | 0.857 | 0.452 | M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
20 |
CDC25C | oncoprotein | 8 | 0.929 | 0.452 | M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain |
21 |
CDCA7 | interactor | 3 | 1.000 | 0 | zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1 Imm51 (PF15595, IPR028956): Immunity protein 51 |
22 |
CDK16 | oncoprotein | 8 | 0.857 | 0.452 | Pkinase (PF00069, IPR000719): Protein kinase domain |
23 |
CDK2 | suppressor | 25 | 0.348 | 84.479 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
24 |
CENPJ | interactor | 12 | 0.409 | 15.748 | DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) |
25 |
CEP128 | interactor | 15 | 0.429 | 34.373 | DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
26 |
CEP135 | interactor | 10 | 0.489 | 13.771 | DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family LPP (PF04728, IPR006817): Lipoprotein leucine-zipper RasGAP_C (PF03836, IPR000593): RasGAP C-terminus Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPD52 (PF04201, IPR007327): Tumour protein D52 family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
27 |
CEP152 | interactor | 10 | 0.422 | 17.019 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18 FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase YtxH (PF12732, IPR024623): YtxH-like protein ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
28 |
CEP162 | interactor | 11 | 0.564 | 13.311 | DivIC (PF04977, IPR007060): Septum formation initiator HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553) DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073) PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69 WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
29 |
CEP170 | interactor | 22 | 0.312 | 88.006 | FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus |
30 |
CEP290 | interactor | 8 | 0.536 | 9.133 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DivIC (PF04977, IPR007060): Septum formation initiator DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) Fez1 (PF06818): Fez1 HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper HemY_N (PF07219, IPR010817): HemY protein N-terminus Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Mnd1 (PF03962, IPR005647): Mnd1 family NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Rho_Binding (PF08912, IPR015008): Rho Binding Sec20 (PF03908, IPR005606): Sec20 Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Swi5 (PF07061, IPR010760): Swi5 TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase KxDL (PF10241, IPR019371): Uncharacterized conserved protein bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290 |
31 |
CEP89 | interactor | 9 | 0.583 | 7.131 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 |
32 |
CHRNA4 | interactor | 1 | 0 | 0 | Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region |
33 |
CLK3 | interactor | 6 | 0.600 | 2.500 | Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
34 |
CNTRL | oncoprotein | 11 | 0.545 | 13.887 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat |
35 |
CRY1 | interactor | 10 | 0.694 | 2.444 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
36 |
CUL3 | protein found in more fusions | 29 | 0.365 | 119.196 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
37 |
CYFIP1 | interactor | 6 | 0.467 | 4.056 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family |
38 |
CYFIP2 | interactor | 6 | 0.733 | 1.472 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger |
39 |
DCAF7 | interactor | 9 | 0.750 | 1.898 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
40 |
DCLRE1A | suppressor | 1 | 0 | 0 | DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase Glyco_hydro_45 (PF02015, IPR000334): Glycosyl hydrolase family 45 Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain |
41 |
DMWD | interactor | 5 | 0.700 | 1.821 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
42 |
DOCK7 | interactor | 10 | 0.556 | 9.312 | DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus |
43 |
DTL | interactor | 7 | 0.810 | 1.041 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
44 |
EIF5 | interactor | 21 | 0.533 | 36.462 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon |
45 |
ELAVL1 | oncoprotein | 42 | 0.172 | 423.710 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
46 |
EML3 | protein found in more fusions | 4 | 1.000 | 0 | HELP (PF03451, IPR005108): HELP motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PQQ_2 (PF13360, IPR002372): PQQ-like domain |
47 |
EPB41L3 | suppressor | 14 | 0.527 | 16.604 | 4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain |
48 |
EPPK1 | interactor | 8 | 0.571 | 6.396 | DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HupF_HypC (PF01455, IPR001109): HupF/HypC family Plectin (PF00681, IPR001101, SM00250): Plectin repeat RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal |
49 |
ERMP1 | interactor | 2 | 1.000 | 0 | DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) Peptidase_M28 (PF04389, IPR007484): Peptidase family M28 |
50 |
EVC2 | interactor | 2 | 1.000 | 0 | HBS1_N (PF08938, IPR015033): HBS1 N-terminus DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Histone_HNS (PF00816, IPR001801): H-NS histone family EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein |
51 |
EXO1 | interactor | 7 | 0.857 | 1.200 | XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain |
52 |
FAM192A | interactor | 3 | 0.667 | 0.500 | VIT1 (PF01988, IPR008217): VIT family Nefa_Nip30_N (PF10187, IPR019331): N-terminal domain of NEFA-interacting nuclear protein NIP30 |
53 |
FAM83G | interactor | 2 | 1.000 | 0 | DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) |
54 |
FBXO45 | interactor | 2 | 1.000 | 0 | SPRY (PF00622, IPR003877, SM00449): SPRY domain F-box-like (PF12937, IPR001810): F-box-like |
55 |
FBXW4 | oncoprotein | 2 | 1.000 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box |
56 |
FERMT2 | interactor | 17 | 0.478 | 34.371 | FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
57 |
FN1 | oncoprotein | 22 | 0.494 | 38.529 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
58 |
FOXO3 | suppressor | 8 | 0.750 | 0.831 | Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
59 |
FRMD5 | interactor | 4 | 1.000 | 0 | FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
60 |
FRMD6 | interactor | 6 | 0.800 | 0.725 | FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain HTH_24 (PF13412, IPR011991): Winged helix-turn-helix DNA-binding |
61 |
FRYL | oncoprotein | 6 | 0.667 | 4.286 | MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
62 |
FXR2 | interactor | 5 | 0.833 | 0.500 | Agenet (PF05641, IPR008395, SM00743): Agenet domain REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein) KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2 |
63 |
G6PD | protein found in more fusions | 19 | 0.654 | 13.778 | G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain |
64 |
GNAI3 | interactor | 12 | 0.545 | 9.089 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
65 |
GRB2 | oncoprotein | 29 | 0.407 | 96.797 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
66 |
GSS | protein found in more fusions | 9 | 0.643 | 4.571 | GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain |
67 |
HDAC4 | oncoprotein | 12 | 0.764 | 4.025 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
68 |
HDAC5 | protein found in more fusions | 16 | 0.648 | 11.787 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
69 |
HDAC7 | protein found in more fusions | 12 | 0.836 | 3.572 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO |
70 |
HMGB3 | interactor | 5 | 0.700 | 1.167 | HMG_box_2 (PF09011, IPR009071): HMG-box domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
71 |
HNRNPK | oncoprotein | 25 | 0.355 | 77.366 | ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
72 |
HOMER3 | protein found in more fusions | 3 | 1.000 | 0 | COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper |
73 |
HSPB1 | oncoprotein | 22 | 0.538 | 31.945 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
74 |
HUWE1 | oncoprotein | 22 | 0.471 | 38.090 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
75 |
ING1 | suppressor | 7 | 0.857 | 0.250 | PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta |
76 |
IRS1 | interactor | 7 | 0.857 | 0.771 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
77 |
IRS2 | oncoprotein | 12 | 0.712 | 5.515 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
78 |
IRS4 | interactor | 17 | 0.529 | 29.262 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain |
79 |
ISOC1 | interactor | 21 | 0.414 | 75.310 | Isochorismatase (PF00857, IPR000868): Isochorismatase family Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain |
80 |
KIAA0930 | interactor | 7 | 0.857 | 1.200 | DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045) |
81 |
KIF1B | suppressor | 7 | 0.571 | 3.360 | FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated |
82 |
KIF23 | interactor | 9 | 0.583 | 5.773 | DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1 |
83 |
KIF5B | interactor | 13 | 0.526 | 21.779 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
84 |
KLC3 | interactor | 7 | 0.667 | 3.619 | TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TPR_12 (PF13424): Tetratricopeptide repeat |
85 |
LATS2 | suppressor | 18 | 0.301 | 51.686 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
86 |
LCA5 | interactor | 10 | 0.644 | 6.803 | IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease |
87 |
LGMN | interactor | 1 | 0 | 0 | Peptidase_C13 (PF01650, IPR001096): Peptidase C13 family |
88 |
LRRK2 | oncoprotein | 9 | 0.786 | 1.643 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
89 |
MAPK7 | oncoprotein | 11 | 0.800 | 1.921 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
90 |
MARK1 | interactor | 4 | 1.000 | 0 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
91 |
MARK2 | protein found in more fusions | 24 | 0.403 | 78.319 | DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
92 |
MARK3 | protein found in more fusions | 15 | 0.648 | 16.449 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
93 |
MARK4 | oncoprotein | 10 | 0.311 | 14.324 | KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
94 |
MAST1 | interactor | 5 | 0.700 | 3.000 | DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain |
95 |
MCM2 | oncoprotein | 23 | 0.541 | 34.347 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
96 |
MDM4 | oncoprotein | 9 | 0.786 | 0.912 | zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
97 |
MEX3B | interactor | 5 | 1.000 | 0 | KH_1 (PF00013, IPR004088, SM00322): KH domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
98 |
MEX3C | interactor | 5 | 0.500 | 1.686 | KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
99 |
MEX3D | interactor | 3 | 1.000 | 0 | KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
100 |
MOB1A | suppressor | 6 | 0.400 | 4.733 | Mob1_phocein (PF03637, IPR005301): Mob1/phocein family |
101 |
MST1R | suppressor | 9 | 0.806 | 1.160 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain |
102 |
MYCBP2 | interactor | 10 | 0.467 | 15.437 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHR (PF08005, IPR012983): PHR domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SH3_3 (PF08239, IPR003646): Bacterial SH3 domain XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
103 |
MYO1E | interactor | 6 | 0.933 | 0.286 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
104 |
NEDD4L | suppressor | 16 | 0.581 | 17.893 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
105 |
NEK1 | interactor | 3 | 0.667 | 0.500 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) Pkinase (PF00069, IPR000719): Protein kinase domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family AAA_23 (PF13476): AAA domain DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
106 |
NHS | interactor | 3 | 0.667 | 0.500 | Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 NHS (PF15273, IPR024845): NHS-like |
107 |
NIN | oncoprotein | 10 | 0.500 | 8.237 | BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase bZIP_1 (PF00170, IPR004827): bZIP transcription factor DivIC (PF04977, IPR007060): Septum formation initiator DivIVA (PF05103, IPR007793): DivIVA protein DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) ZapB (PF06005, IPR009252): Cell division protein ZapB FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Rho_Binding (PF08912, IPR015008): Rho Binding TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205) Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 FlxA (PF14282, IPR025577): FlxA-like protein DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
108 |
NOS1AP | interactor | 3 | 0.667 | 0.500 | Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) |
109 |
NR3C1 | protein found in more fusions | 5 | 0.833 | 0.286 | GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
110 |
NSUN4 | interactor | 2 | 1.000 | 0 | DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) RSRP (PF17069): Arginine/Serine-Rich protein 1 |
111 |
NTRK1 | oncoprotein | 49 | 0.269 | 421.639 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
112 |
OARD1 | interactor | 1 | 0 | 0 | 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Macro (PF01661, IPR002589, SM00506): Macro domain |
113 |
OPTN | protein found in more fusions | 9 | 0.643 | 3.627 | ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
114 |
OSBPL5 | interactor | 1 | 0 | 0 | Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain |
115 |
PAFAH1B1 | suppressor | 15 | 0.407 | 32.633 | LisH (PF08513, IPR013720, SM00667): LisH Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
116 |
PAK2 | protein found in more fusions | 16 | 0.562 | 16.664 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
117 |
PARD3 | interactor | 19 | 0.462 | 42.610 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term |
118 |
PARD6A | interactor | 13 | 0.474 | 20.157 | PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
119 |
PARD6B | interactor | 11 | 0.582 | 8.973 | PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
120 |
PARD6G | interactor | 7 | 0.810 | 0.959 | PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
121 |
PARK2 | suppressor | 17 | 0.258 | 50.629 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
122 |
PCYT2 | interactor | 4 | 0.667 | 0.722 | CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like DUF765 (PF05570, IPR008484): Circovirus protein of unknown function (DUF765) |
123 |
PDIA4 | interactor | 18 | 0.412 | 47.233 | Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family |
124 |
PDPK1 | interactor | 6 | 0.700 | 0.507 | Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain |
125 |
PIK3CA | oncoprotein | 7 | 0.714 | 1.588 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
126 |
PPP1CA | suppressor | 22 | 0.229 | 79.070 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
127 |
PRKCI | interactor | 18 | 0.353 | 54.742 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
128 |
PRKCZ | interactor | 17 | 0.483 | 27.227 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
129 |
PTMA | oncoprotein | 9 | 0.639 | 7.340 | Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family |
130 |
PTOV1 | interactor | 1 | 0 | 0 | Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 |
131 |
RAE1 | interactor | 7 | 0.476 | 5.556 | Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
132 |
RAF1 | oncoprotein | 18 | 0.588 | 22.028 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
133 |
RASSF2 | suppressor | 7 | 0.762 | 2.733 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
134 |
RASSF8 | suppressor | 13 | 0.487 | 18.317 | ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
135 |
RBM7 | interactor | 7 | 0.714 | 2.098 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
136 |
REEP4 | interactor | 2 | 1.000 | 0 | TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family |
137 |
REM1 | interactor | 4 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family AAA_33 (PF13671): AAA domain |
138 |
RIMS1 | interactor | 1 | 0 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 |
139 |
RIMS2 | interactor | 1 | 0 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
140 |
RPGRIP1L | interactor | 11 | 0.436 | 22.678 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FtsL (PF04999, IPR011922): Cell division protein FtsL T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1 BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4497 (PF14924): Protein of unknown function (DUF4497) |
141 |
RPH3A | interactor | 2 | 1.000 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger |
142 |
RPS6KB2 | interactor | 7 | 0.571 | 3.769 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
143 |
RUSC2 | interactor | 2 | 1.000 | 0 | RUN (PF02759, IPR004012, SM00593): RUN domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
144 |
SAMSN1 | interactor | 6 | 1.000 | 0 | SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein |
145 |
SAV1 | oncoprotein | 8 | 0.571 | 5.253 | WW (PF00397, IPR001202, SM00456): WW domain |
146 |
SIK3 | oncoprotein | 7 | 0.810 | 0.536 | GET2 (PF08690, IPR028143): GET complex subunit GET2 Pkinase (PF00069, IPR000719): Protein kinase domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 |
147 |
SNCAIP | protein found in more fusions | 4 | 0.667 | 1.000 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain |
148 |
SNRPD2 | interactor | 10 | 0.489 | 7.426 | LSM (PF01423, IPR001163): LSM domain |
149 |
SNRPE | interactor | 8 | 0.643 | 3.823 | LSM (PF01423, IPR001163): LSM domain |
150 |
SPRYD3 | interactor | 2 | 1.000 | 0 | Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein SPRY (PF00622, IPR003877, SM00449): SPRY domain |
151 |
SRRM2 | interactor | 19 | 0.485 | 34.558 | cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) |
152 |
SRSF8 | interactor | 4 | 0.500 | 0.733 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX (PF03105, IPR004331): SPX domain |
153 |
TBCB | interactor | 16 | 0.542 | 21.144 | CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain |
154 |
TFB1M | interactor | 1 | 0 | 0 | RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase |
155 |
TLX2 | interactor | 1 | 0 | 0 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
156 |
TMEM17 | interactor | 10 | 0.289 | 16.991 | Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043) |
157 |
TNFAIP3 | suppressor | 8 | 0.857 | 0.250 | OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain |
158 |
TNK1 | suppressor | 7 | 1.000 | 0 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase |
159 |
TP53BP2 | suppressor | 24 | 0.322 | 109.364 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
160 |
TRIM32 | suppressor | 9 | 0.964 | 0.125 | NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
161 |
TUBG1 | protein found in more fusions | 13 | 0.348 | 18.225 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
162 |
UBE2R2 | protein found in more fusions | 5 | 1.000 | 0 | NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
163 |
UBFD1 | interactor | 12 | 0.591 | 6.660 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
164 |
USP4 | oncoprotein | 5 | 0.667 | 0.650 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain |
165 |
USP43 | interactor | 4 | 0.667 | 1.333 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
166 |
USP46 | interactor | 4 | 0.833 | 0.667 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
167 |
VCL | oncoprotein | 20 | 0.596 | 20.066 | Vinculin (PF01044, IPR006077): Vinculin family |
168 |
VCP | protein found in more fusions | 32 | 0.441 | 82.742 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
169 |
WDR20 | interactor | 7 | 0.476 | 6.665 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
170 |
WDR62 | interactor | 9 | 0.714 | 2.705 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
171 |
WWC1 | interactor | 10 | 0.600 | 5.408 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein WW (PF00397, IPR001202, SM00456): WW domain |
172 |
XPO1 | interactor | 51 | 0.171 | 635.507 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
173 |
YAP1 | suppressor | 15 | 0.562 | 14.623 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
174 |
YWHAB | interactor | 82 | 0.146 | 1275.968 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
175 |
YWHAE | oncoprotein | 88 | 0.148 | 1555.010 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
176 |
YWHAG | protein found in more fusions | 86 | 0.149 | 1432.467 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
177 |
YWHAQ | interactor | 83 | 0.145 | 1429.070 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
178 |
YWHAZ | protein found in more fusions | 88 | 0.144 | 1534.808 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
179 |
ZC3H14 | interactor | 2 | 1.000 | 0 | PWI (PF01480, IPR002483, SM00311): PWI domain zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger |
180 |
ZFP36 | suppressor | 5 | 0.700 | 0.465 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) |