Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins YWHAH (from a repository: Sat Dec 3 17:11:37 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 180 The number (and %) of the onco-proteins 54 (30.00 %) The number (and %) of the tumor suppressors 22 (12.22 %) Total number of binary PPIs (saturation %) 1246 (7.73 %) The number (and %) of affected PPIs 180 (14.45 %) The number of possible different fusions 37 PPI diameter 2 PPI radius 1 The average degree of PPI 13.222 Assortativity coefficient -0.1986 The network average Clustering coefficient 0.579 The number (and %) of a zero Clustering coefficients 13 (7.22 %) The number (and %) of a zero Betweenness Centrality 35 (19.44 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: YWHAH	All fusions : BF904422; CN353393;
Proteins found in more fusions	TUBG1 (see 1 fusions); CBL (see 1 fusions); HDAC7 (see 1 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); YWHAH (see 2 fusions); MDM4 (see 2 fusions); OPTN (see 1 fusions); UBE2R2 (see 1 fusions); CCDC88A (see 3 fusions); GSS (see 1 fusions); SNCAIP (see 1 fusions); YWHAZ (see 1 fusions); MARK3 (see 1 fusions); PAFAH1B1 (see 1 fusions); VCL (see 2 fusions); HDAC5 (see 1 fusions); FN1/YWHAG (see 1 fusions); PAK2 (see 2 fusions); LRRK2 (see 1 fusions); HOMER3 (see 1 fusions); YWHAE/KIF1B (see 1 fusions); YWHAG (see 1 fusions); VCP (see 4 fusions); NR3C1 (see 8 fusions); NIN (see 1 fusions); HUWE1 (see 2 fusions); HDAC4 (see 1 fusions); MARK2 (see 2 fusions); EML3 (see 1 fusions); NEDD4L (see 3 fusions); BAG3 (see 4 fusions); MCM2 (see 1 fusions); BRAF (see 3 fusions); G6PD (see 3 fusions); HSPB1 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	YWHAH	parental protein	180	0.063	18760.774	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
2	ABCA2	interactor	1	0	0	ABC_tran (PF00005, IPR003439): ABC transporter ABC2_membrane_3 (PF12698): ABC-2 family transporter protein AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
3	ABCE1	interactor	12	0.327	14.554	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
4	ABL1	oncoprotein	19	0.542	22.322	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
5	ALDH7A1	interactor	12	0.561	11.197	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6	ARAF	oncoprotein	10	0.844	1.356	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7	ARHGEF2	oncoprotein	14	0.582	16.559	IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8	ARRB1	interactor	11	0.764	2.309	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9	ARRB2	interactor	17	0.515	28.577	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10	BAD	oncoprotein	12	0.697	6.264	Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
11	BAG3	oncoprotein	14	0.564	13.208	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
12	BRAF	oncoprotein	14	0.654	11.728	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
13	C10orf2	interactor	1	0	0	T2SSE (PF00437, IPR001482): Type II/IV secretion system protein SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain AAA_25 (PF13481): AAA domain
14	CAPNS1	interactor	19	0.474	32.854	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
15	CBL	suppressor	15	0.604	15.286	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
16	CC2D2A	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240) SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
17	CCDC8	interactor	22	0.352	69.706	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
18	CCDC88A	protein found in more fusions	10	0.417	9.849	bZIP_1 (PF00170, IPR004827): bZIP transcription factor ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) HOOK (PF05622, IPR008636): HOOK protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 KxDL (PF10241, IPR019371): Uncharacterized conserved protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
19	CDC25B	oncoprotein	8	0.857	0.452	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
20	CDC25C	oncoprotein	8	0.929	0.452	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21	CDCA7	interactor	3	1.000	0	zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1 Imm51 (PF15595, IPR028956): Immunity protein 51
22	CDK16	oncoprotein	8	0.857	0.452	Pkinase (PF00069, IPR000719): Protein kinase domain
23	CDK2	suppressor	25	0.348	84.479	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
24	CENPJ	interactor	12	0.409	15.748	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
25	CEP128	interactor	15	0.429	34.373	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26	CEP135	interactor	10	0.489	13.771	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family LPP (PF04728, IPR006817): Lipoprotein leucine-zipper RasGAP_C (PF03836, IPR000593): RasGAP C-terminus Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPD52 (PF04201, IPR007327): Tumour protein D52 family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
27	CEP152	interactor	10	0.422	17.019	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18 FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase YtxH (PF12732, IPR024623): YtxH-like protein ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
28	CEP162	interactor	11	0.564	13.311	DivIC (PF04977, IPR007060): Septum formation initiator HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553) DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073) PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69 WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
29	CEP170	interactor	22	0.312	88.006	FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus
30	CEP290	interactor	8	0.536	9.133	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DivIC (PF04977, IPR007060): Septum formation initiator DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) Fez1 (PF06818): Fez1 HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper HemY_N (PF07219, IPR010817): HemY protein N-terminus Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Mnd1 (PF03962, IPR005647): Mnd1 family NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Rho_Binding (PF08912, IPR015008): Rho Binding Sec20 (PF03908, IPR005606): Sec20 Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Swi5 (PF07061, IPR010760): Swi5 TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase KxDL (PF10241, IPR019371): Uncharacterized conserved protein bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
31	CEP89	interactor	9	0.583	7.131	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
32	CHRNA4	interactor	1	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
33	CLK3	interactor	6	0.600	2.500	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
34	CNTRL	oncoprotein	11	0.545	13.887	APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat
35	CRY1	interactor	10	0.694	2.444	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
36	CUL3	protein found in more fusions	29	0.365	119.196	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
37	CYFIP1	interactor	6	0.467	4.056	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
38	CYFIP2	interactor	6	0.733	1.472	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger
39	DCAF7	interactor	9	0.750	1.898	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40	DCLRE1A	suppressor	1	0	0	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase Glyco_hydro_45 (PF02015, IPR000334): Glycosyl hydrolase family 45 Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
41	DMWD	interactor	5	0.700	1.821	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
42	DOCK7	interactor	10	0.556	9.312	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
43	DTL	interactor	7	0.810	1.041	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
44	EIF5	interactor	21	0.533	36.462	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
45	ELAVL1	oncoprotein	42	0.172	423.710	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
46	EML3	protein found in more fusions	4	1.000	0	HELP (PF03451, IPR005108): HELP motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PQQ_2 (PF13360, IPR002372): PQQ-like domain
47	EPB41L3	suppressor	14	0.527	16.604	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain
48	EPPK1	interactor	8	0.571	6.396	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HupF_HypC (PF01455, IPR001109): HupF/HypC family Plectin (PF00681, IPR001101, SM00250): Plectin repeat RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal
49	ERMP1	interactor	2	1.000	0	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
50	EVC2	interactor	2	1.000	0	HBS1_N (PF08938, IPR015033): HBS1 N-terminus DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Histone_HNS (PF00816, IPR001801): H-NS histone family EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
51	EXO1	interactor	7	0.857	1.200	XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
52	FAM192A	interactor	3	0.667	0.500	VIT1 (PF01988, IPR008217): VIT family Nefa_Nip30_N (PF10187, IPR019331): N-terminal domain of NEFA-interacting nuclear protein NIP30
53	FAM83G	interactor	2	1.000	0	DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
54	FBXO45	interactor	2	1.000	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain F-box-like (PF12937, IPR001810): F-box-like
55	FBXW4	oncoprotein	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
56	FERMT2	interactor	17	0.478	34.371	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
57	FN1	oncoprotein	22	0.494	38.529	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
58	FOXO3	suppressor	8	0.750	0.831	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
59	FRMD5	interactor	4	1.000	0	FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
60	FRMD6	interactor	6	0.800	0.725	FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain HTH_24 (PF13412, IPR011991): Winged helix-turn-helix DNA-binding
61	FRYL	oncoprotein	6	0.667	4.286	MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
62	FXR2	interactor	5	0.833	0.500	Agenet (PF05641, IPR008395, SM00743): Agenet domain REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein) KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
63	G6PD	protein found in more fusions	19	0.654	13.778	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
64	GNAI3	interactor	12	0.545	9.089	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
65	GRB2	oncoprotein	29	0.407	96.797	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
66	GSS	protein found in more fusions	9	0.643	4.571	GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
67	HDAC4	oncoprotein	12	0.764	4.025	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
68	HDAC5	protein found in more fusions	16	0.648	11.787	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
69	HDAC7	protein found in more fusions	12	0.836	3.572	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
70	HMGB3	interactor	5	0.700	1.167	HMG_box_2 (PF09011, IPR009071): HMG-box domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
71	HNRNPK	oncoprotein	25	0.355	77.366	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
72	HOMER3	protein found in more fusions	3	1.000	0	COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding WH1 (PF00568, IPR000697, SM00461): WH1 domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
73	HSPB1	oncoprotein	22	0.538	31.945	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
74	HUWE1	oncoprotein	22	0.471	38.090	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
75	ING1	suppressor	7	0.857	0.250	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
76	IRS1	interactor	7	0.857	0.771	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
77	IRS2	oncoprotein	12	0.712	5.515	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
78	IRS4	interactor	17	0.529	29.262	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
79	ISOC1	interactor	21	0.414	75.310	Isochorismatase (PF00857, IPR000868): Isochorismatase family Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
80	KIAA0930	interactor	7	0.857	1.200	DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045)
81	KIF1B	suppressor	7	0.571	3.360	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
82	KIF23	interactor	9	0.583	5.773	DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
83	KIF5B	interactor	13	0.526	21.779	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
84	KLC3	interactor	7	0.667	3.619	TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TPR_12 (PF13424): Tetratricopeptide repeat
85	LATS2	suppressor	18	0.301	51.686	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
86	LCA5	interactor	10	0.644	6.803	IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
87	LGMN	interactor	1	0	0	Peptidase_C13 (PF01650, IPR001096): Peptidase C13 family
88	LRRK2	oncoprotein	9	0.786	1.643	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
89	MAPK7	oncoprotein	11	0.800	1.921	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
90	MARK1	interactor	4	1.000	0	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
91	MARK2	protein found in more fusions	24	0.403	78.319	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
92	MARK3	protein found in more fusions	15	0.648	16.449	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
93	MARK4	oncoprotein	10	0.311	14.324	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
94	MAST1	interactor	5	0.700	3.000	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain
95	MCM2	oncoprotein	23	0.541	34.347	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
96	MDM4	oncoprotein	9	0.786	0.912	zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
97	MEX3B	interactor	5	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
98	MEX3C	interactor	5	0.500	1.686	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
99	MEX3D	interactor	3	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
100	MOB1A	suppressor	6	0.400	4.733	Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
101	MST1R	suppressor	9	0.806	1.160	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain
102	MYCBP2	interactor	10	0.467	15.437	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHR (PF08005, IPR012983): PHR domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SH3_3 (PF08239, IPR003646): Bacterial SH3 domain XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
103	MYO1E	interactor	6	0.933	0.286	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
104	NEDD4L	suppressor	16	0.581	17.893	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
105	NEK1	interactor	3	0.667	0.500	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) Pkinase (PF00069, IPR000719): Protein kinase domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family AAA_23 (PF13476): AAA domain DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
106	NHS	interactor	3	0.667	0.500	Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 NHS (PF15273, IPR024845): NHS-like
107	NIN	oncoprotein	10	0.500	8.237	BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase bZIP_1 (PF00170, IPR004827): bZIP transcription factor DivIC (PF04977, IPR007060): Septum formation initiator DivIVA (PF05103, IPR007793): DivIVA protein DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) ZapB (PF06005, IPR009252): Cell division protein ZapB FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Rho_Binding (PF08912, IPR015008): Rho Binding TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205) Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 FlxA (PF14282, IPR025577): FlxA-like protein DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
108	NOS1AP	interactor	3	0.667	0.500	Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
109	NR3C1	protein found in more fusions	5	0.833	0.286	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
110	NSUN4	interactor	2	1.000	0	DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) RSRP (PF17069): Arginine/Serine-Rich protein 1
111	NTRK1	oncoprotein	49	0.269	421.639	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
112	OARD1	interactor	1	0	0	3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Macro (PF01661, IPR002589, SM00506): Macro domain
113	OPTN	protein found in more fusions	9	0.643	3.627	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
114	OSBPL5	interactor	1	0	0	Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain
115	PAFAH1B1	suppressor	15	0.407	32.633	LisH (PF08513, IPR013720, SM00667): LisH Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
116	PAK2	protein found in more fusions	16	0.562	16.664	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
117	PARD3	interactor	19	0.462	42.610	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
118	PARD6A	interactor	13	0.474	20.157	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
119	PARD6B	interactor	11	0.582	8.973	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
120	PARD6G	interactor	7	0.810	0.959	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
121	PARK2	suppressor	17	0.258	50.629	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
122	PCYT2	interactor	4	0.667	0.722	CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like DUF765 (PF05570, IPR008484): Circovirus protein of unknown function (DUF765)
123	PDIA4	interactor	18	0.412	47.233	Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family
124	PDPK1	interactor	6	0.700	0.507	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
125	PIK3CA	oncoprotein	7	0.714	1.588	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
126	PPP1CA	suppressor	22	0.229	79.070	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
127	PRKCI	interactor	18	0.353	54.742	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
128	PRKCZ	interactor	17	0.483	27.227	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
129	PTMA	oncoprotein	9	0.639	7.340	Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
130	PTOV1	interactor	1	0	0	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
131	RAE1	interactor	7	0.476	5.556	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
132	RAF1	oncoprotein	18	0.588	22.028	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
133	RASSF2	suppressor	7	0.762	2.733	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
134	RASSF8	suppressor	13	0.487	18.317	ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
135	RBM7	interactor	7	0.714	2.098	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
136	REEP4	interactor	2	1.000	0	TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
137	REM1	interactor	4	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family AAA_33 (PF13671): AAA domain
138	RIMS1	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
139	RIMS2	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
140	RPGRIP1L	interactor	11	0.436	22.678	bZIP_1 (PF00170, IPR004827): bZIP transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FtsL (PF04999, IPR011922): Cell division protein FtsL T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1 BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4497 (PF14924): Protein of unknown function (DUF4497)
141	RPH3A	interactor	2	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
142	RPS6KB2	interactor	7	0.571	3.769	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
143	RUSC2	interactor	2	1.000	0	RUN (PF02759, IPR004012, SM00593): RUN domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
144	SAMSN1	interactor	6	1.000	0	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
145	SAV1	oncoprotein	8	0.571	5.253	WW (PF00397, IPR001202, SM00456): WW domain
146	SIK3	oncoprotein	7	0.810	0.536	GET2 (PF08690, IPR028143): GET complex subunit GET2 Pkinase (PF00069, IPR000719): Protein kinase domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
147	SNCAIP	protein found in more fusions	4	0.667	1.000	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
148	SNRPD2	interactor	10	0.489	7.426	LSM (PF01423, IPR001163): LSM domain
149	SNRPE	interactor	8	0.643	3.823	LSM (PF01423, IPR001163): LSM domain
150	SPRYD3	interactor	2	1.000	0	Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein SPRY (PF00622, IPR003877, SM00449): SPRY domain
151	SRRM2	interactor	19	0.485	34.558	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
152	SRSF8	interactor	4	0.500	0.733	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX (PF03105, IPR004331): SPX domain
153	TBCB	interactor	16	0.542	21.144	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
154	TFB1M	interactor	1	0	0	RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
155	TLX2	interactor	1	0	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
156	TMEM17	interactor	10	0.289	16.991	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
157	TNFAIP3	suppressor	8	0.857	0.250	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
158	TNK1	suppressor	7	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
159	TP53BP2	suppressor	24	0.322	109.364	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
160	TRIM32	suppressor	9	0.964	0.125	NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
161	TUBG1	protein found in more fusions	13	0.348	18.225	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
162	UBE2R2	protein found in more fusions	5	1.000	0	NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
163	UBFD1	interactor	12	0.591	6.660	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
164	USP4	oncoprotein	5	0.667	0.650	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
165	USP43	interactor	4	0.667	1.333	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
166	USP46	interactor	4	0.833	0.667	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
167	VCL	oncoprotein	20	0.596	20.066	Vinculin (PF01044, IPR006077): Vinculin family
168	VCP	protein found in more fusions	32	0.441	82.742	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
169	WDR20	interactor	7	0.476	6.665	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
170	WDR62	interactor	9	0.714	2.705	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
171	WWC1	interactor	10	0.600	5.408	APG6 (PF04111, IPR007243): Autophagy protein Apg6 bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein WW (PF00397, IPR001202, SM00456): WW domain
172	XPO1	interactor	51	0.171	635.507	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
173	YAP1	suppressor	15	0.562	14.623	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
174	YWHAB	interactor	82	0.146	1275.968	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
175	YWHAE	oncoprotein	88	0.148	1555.010	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
176	YWHAG	protein found in more fusions	86	0.149	1432.467	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
177	YWHAQ	interactor	83	0.145	1429.070	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
178	YWHAZ	protein found in more fusions	88	0.144	1534.808	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
179	ZC3H14	interactor	2	1.000	0	PWI (PF01480, IPR002483, SM00311): PWI domain zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
180	ZFP36	suppressor	5	0.700	0.465	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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