Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins YWHAG (from a repository: Sun Dec 4 03:44:16 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 272 The number (and %) of the onco-proteins 99 (36.40 %) The number (and %) of the tumor suppressors 25 (9.19 %) Total number of binary PPIs (saturation %) 2423 (6.57 %) The number (and %) of affected PPIs 272 (11.23 %) The number of possible different fusions 62 PPI diameter 2 PPI radius 1 The average degree of PPI 16.993 Assortativity coefficient -0.2715 The network average Clustering coefficient 0.515 The number (and %) of a zero Clustering coefficients 8 (2.94 %) The number (and %) of a zero Betweenness Centrality 24 (8.82 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: YWHAG	All fusions
Proteins found in more fusions	GRK5 (see 4 fusions); EEF1G (see 1 fusions); PRPF19 (see 2 fusions); GRB2 (see 1 fusions); MAP3K1 (see 1 fusions); YWHAH (see 2 fusions); MDM4 (see 2 fusions); OPTN (see 1 fusions); UBE2R2 (see 1 fusions); GSS (see 1 fusions); YWHAZ (see 1 fusions); MARK3 (see 1 fusions); PAFAH1B1 (see 1 fusions); RAB11FIP2 (see 1 fusions); HDAC5 (see 1 fusions); APP (see 4 fusions); VCP (see 4 fusions); APP/ALB (see 2 fusions); HUWE1 (see 2 fusions); HDAC4 (see 1 fusions); YWHAG/FN1 (see 1 fusions); MARK2 (see 2 fusions); PAK4 (see 1 fusions); NEDD4L (see 3 fusions); SNRNP200 (see 3 fusions); BAG3 (see 4 fusions); TGM2 (see 4 fusions); ATP5A1 (see 1 fusions); GAPDH (see 2 fusions); SH3BP4 (see 2 fusions); PPFIBP1 (see 1 fusions); MAP3K2 (see 2 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); PRKCD (see 2 fusions); CUL3 (see 1 fusions); ZBTB21 (see 2 fusions); PIK3R1 (see 1 fusions); VCL (see 2 fusions); COPS5 (see 1 fusions); MIEF1 (see 1 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); LRRK2 (see 1 fusions); SS18 (see 1 fusions); PRPF40A (see 2 fusions); YWHAE/KIF1B (see 1 fusions); YWHAG (see 1 fusions); LUC7L2 (see 2 fusions); PUF60 (see 2 fusions); FOXO1 (see 1 fusions); PABPC1 (see 2 fusions); EML3 (see 1 fusions); ATP5A1/HUWE1 (see 2 fusions); RABEP1 (see 1 fusions); EDC3 (see 1 fusions); NDEL1 (see 1 fusions); MCM2 (see 1 fusions); BRAF (see 3 fusions); G6PD (see 3 fusions); KAT5 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	YWHAG	parental protein	272	0.056	37592.868	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
2	ABL1	oncoprotein	24	0.455	45.365	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AFDN	oncoprotein	12	0.591	5.368	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FHA (PF00498, IPR000253, SM00240): FHA domain MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family MAS20 (PF02064, IPR002056): MAS20 protein import receptor Pap_E4 (PF02711, IPR003861): E4 protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain ARGLU (PF15346): Arginine and glutamate-rich 1
4	AKAP13	oncoprotein	5	0.700	0.933	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) RII_binding_1 (PF10522, IPR018459): RII binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5	AKT1	oncoprotein	30	0.229	167.735	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6	ALB	protein found in more fusions	8	0.321	7.813	Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
7	ALDH7A1	interactor	9	0.611	3.308	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
8	AMOT	oncoprotein	16	0.267	33.800	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
9	ANKHD1-EIF4EBP3	interactor	2	1.000	0	DUF572 (PF04502, IPR007590): Family of unknown function (DUF572) Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein KH_1 (PF00013, IPR004088, SM00322): KH domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
10	ANKS1A	interactor	6	0.467	3.062	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
11	APBB1	interactor	10	0.333	8.569	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) WW (PF00397, IPR001202, SM00456): WW domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
12	APP	protein found in more fusions	56	0.122	799.746	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
13	ARAF	oncoprotein	13	0.615	9.355	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
14	ARHGEF2	oncoprotein	14	0.604	10.647	IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
15	ARRB1	interactor	24	0.359	62.757	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
16	ARRB2	interactor	35	0.262	165.455	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
17	ATF2	oncoprotein	16	0.295	30.305	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
18	ATP5A1	protein found in more fusions	24	0.518	22.758	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
19	ATP6V0B	interactor	1	0	0	ATP-synt_C (PF00137, IPR002379): ATP synthase subunit C PIRT (PF15099, IPR028068): Phosphoinositide-interacting protein family
20	BAD	oncoprotein	13	0.756	4.335	Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
21	BAG3	oncoprotein	30	0.212	177.516	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
22	BAIAP2	interactor	8	0.667	2.378	IMD (PF08397, IPR013606): IRSp53/MIM homology domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
23	BCLAF1	oncoprotein	19	0.322	37.520	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
24	BRAF	oncoprotein	17	0.542	15.908	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
25	BTRC	oncoprotein	23	0.338	73.440	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
26	C1QBP	interactor	23	0.368	48.433	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
27	CAPNS1	interactor	13	0.538	11.445	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
28	CASP3	interactor	11	0.422	8.838	Peptidase_C14 (PF00656, IPR011600): Caspase domain
29	CCDC8	interactor	43	0.187	347.692	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
30	CDC25B	oncoprotein	13	0.513	15.730	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
31	CDC25C	oncoprotein	9	0.833	0.720	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
32	CDC5L	interactor	42	0.283	251.038	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
33	CDK11B	oncoprotein	9	0.714	2.319	DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
34	CDK16	oncoprotein	10	0.711	2.344	Pkinase (PF00069, IPR000719): Protein kinase domain
35	CDK17	interactor	8	0.607	1.850	Pkinase (PF00069, IPR000719): Protein kinase domain
36	CDK2	suppressor	48	0.198	461.644	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
37	CENPJ	interactor	11	0.436	15.018	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
38	CEP89	interactor	8	0.393	9.975	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
39	CEP95	interactor	3	0.667	0.222	HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain IncA (PF04156, IPR007285): IncA protein DUF4094 (PF13334, IPR025298): Domain of unknown function (DUF4094) DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
40	CFAP20	oncoprotein	2	1.000	0	DUF667 (PF05018, IPR007714): Protein of unknown function (DUF667)
41	CGN	interactor	8	0.429	5.095	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Filament (PF00038, IPR001664): Intermediate filament protein Laminin_II (PF06009, IPR010307): Laminin Domain II Myosin_tail_1 (PF01576, IPR002928): Myosin tail DUF4559 (PF15112, IPR027897): Domain of unknown function (DUF4559) Leu_zip (PF15294): Leucine zipper
42	CGNL1	interactor	3	1.000	0	Abhydrolase_4 (PF08386, IPR013595): TAP-like protein Myosin_tail_1 (PF01576, IPR002928): Myosin tail
43	CHAF1A	interactor	11	0.489	7.664	CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
44	CKB	interactor	20	0.268	59.240	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
45	CLASP1	interactor	10	0.689	3.079	HEAT (PF02985, IPR000357): HEAT repeat TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
46	CLK1	interactor	19	0.248	67.015	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
47	CLK2	interactor	14	0.372	21.321	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Pkinase (PF00069, IPR000719): Protein kinase domain zf-met (PF12874): Zinc-finger of C2H2 type
48	CLK3	interactor	18	0.324	40.191	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
49	COPS5	protein found in more fusions	46	0.269	265.305	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
50	CRK	oncoprotein	15	0.343	28.765	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51	CRTC2	oncoprotein	4	0.667	0.111	TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
52	CRTC3	oncoprotein	5	0.700	0.673	TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
53	CUL3	protein found in more fusions	63	0.225	698.227	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
54	CUL7	protein found in more fusions	48	0.220	330.672	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
55	DCAF7	interactor	14	0.527	10.416	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
56	DDX27	interactor	5	0.500	0.483	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
57	DDX39B	interactor	15	0.410	23.737	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
58	DENND4A	interactor	5	0.700	0.730	dDENN (PF03455, IPR005112, SM00801): dDENN domain DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain Papo_T_antigen (PF02380, IPR003354): T-antigen specific domain uDENN (PF03456, IPR005113, SM00800): uDENN domain PPR_2 (PF13041, IPR002885): PPR repeat family
59	DFFA	suppressor	6	0.533	1.965	CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
60	DHX15	interactor	34	0.357	122.248	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
61	DISC1	interactor	9	0.472	9.546	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
62	DOCK7	interactor	10	0.622	4.372	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
63	DTL	interactor	8	0.714	0.774	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
64	DYRK1A	oncoprotein	13	0.409	12.553	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
65	EDC3	protein found in more fusions	7	0.867	0.111	FDF (PF09532, IPR019050, SM01199): FDF domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus LSM14 (PF12701, IPR025609): Scd6-like Sm domain Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3 DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
66	EEF1G	protein found in more fusions	19	0.386	31.889	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
67	ELAVL1	oncoprotein	53	0.192	534.288	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
68	EML3	protein found in more fusions	4	1.000	0	HELP (PF03451, IPR005108): HELP motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat PQQ_2 (PF13360, IPR002372): PQQ-like domain
69	EPB41L2	interactor	8	0.607	3.049	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain SAB (PF04382, IPR007477): SAB domain TCP (PF03634, IPR005333): TCP family transcription factor
70	EPB41L3	suppressor	20	0.437	47.173	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain
71	ERC1	oncoprotein	7	0.476	5.908	RBD-FIP (PF09457, IPR019018): FIP domain BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
72	EXO1	interactor	8	0.750	1.285	XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
73	FAM13B	interactor	5	0.700	0.422	COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 MazG (PF03819, IPR004518): MazG nucleotide pyrophosphohydrolase domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Drc1-Sld2 (PF11719, IPR021110): DNA replication and checkpoint protein GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
74	FAM189A2	interactor	7	0.619	2.405	CD20 (PF04103, IPR007237): CD20-like family
75	FAM53C	interactor	6	0.733	0.643	FAM53 (PF15242, IPR029356): Family of FAM53
76	FAM65B	interactor	2	1.000	0	Glu-tRNAGln (PF02686, IPR003837): Glu-tRNAGln amidotransferase C subunit HEAT_2 (PF13646): HEAT repeats PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
77	FBXO6	interactor	28	0.272	87.358	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
78	FBXW11	interactor	36	0.217	234.427	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
79	FN1	oncoprotein	44	0.247	275.108	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
80	FOXO1	suppressor	6	0.700	0.407	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
81	FRMD5	interactor	4	1.000	0	FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
82	FRMD6	interactor	5	0.800	0.650	FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain HTH_24 (PF13412, IPR011991): Winged helix-turn-helix DNA-binding
83	FRYL	oncoprotein	7	0.571	3.283	MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
84	G6PD	protein found in more fusions	23	0.524	32.117	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
85	GAPDH	oncoprotein	31	0.299	119.096	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
86	GBF1	interactor	7	0.762	1.121	DUF1045 (PF06299, IPR009389): Protein of unknown function (DUF1045) DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) DUF758 (PF05527, IPR008477): Domain of unknown function (DUF758) Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
87	GRB2	oncoprotein	38	0.314	218.275	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
88	GRK5	protein found in more fusions	17	0.300	35.155	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
89	GSK3A	interactor	6	0.467	4.286	Pkinase (PF00069, IPR000719): Protein kinase domain
90	GSS	protein found in more fusions	8	0.619	2.340	GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
91	HDAC4	oncoprotein	17	0.533	21.426	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
92	HDAC5	protein found in more fusions	32	0.340	98.330	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
93	HDAC7	protein found in more fusions	13	0.773	5.743	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
94	HIST1H3A	interactor	19	0.327	54.059	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
95	HIVEP2	interactor	5	1.000	0	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
96	HMGB2	interactor	11	0.418	12.127	HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
97	HNF1A	oncoprotein	7	0.867	0.206	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
98	HNRNPH1	oncoprotein	23	0.407	33.798	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
99	HOXC10	interactor	1	0	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
100	HSPA1A	interactor	18	0.405	28.148	HSP70 (PF00012, IPR013126): Hsp70 protein
101	HSPA9	oncoprotein	26	0.298	58.711	HSP70 (PF00012, IPR013126): Hsp70 protein
102	HUWE1	oncoprotein	35	0.328	121.484	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
103	IGF1R	oncoprotein	9	0.528	4.633	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
104	IGKV1-12	interactor	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain
105	IL7R	interactor	7	0.571	1.633	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
106	ING1	suppressor	10	0.556	4.335	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
107	IRS2	oncoprotein	13	0.654	5.199	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
108	IRS4	interactor	17	0.522	21.285	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
109	ITGA4	interactor	29	0.344	66.314	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
110	KAT5	suppressor	12	0.345	16.516	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
111	KDR	oncoprotein	4	0.667	0.472	Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt) Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
112	KIAA0408	interactor	3	0.667	0.222	IncA (PF04156, IPR007285): IncA protein DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
113	KIAA0930	interactor	9	0.667	2.762	DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045)
114	KIF1B	suppressor	8	0.500	5.752	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
115	KIF1C	interactor	7	0.810	1.107	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
116	KIF23	interactor	15	0.400	31.512	DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730) Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
117	KIF5B	interactor	18	0.575	19.006	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
118	KIF5C	interactor	7	0.952	0.182	DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
119	KLC1	interactor	18	0.412	44.227	Gly_radical (PF01228, IPR001150): Glycine radical SOGA (PF11365, IPR027881): Protein SOGA TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
120	KLC2	interactor	14	0.593	12.357	TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
121	KLC3	interactor	10	0.667	3.463	TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TPR_12 (PF13424): Tetratricopeptide repeat
122	KLC4	interactor	15	0.552	19.704	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat LUD_dom (PF02589): LUD domain
123	KRT18	interactor	14	0.372	18.317	Filament (PF00038, IPR001664): Intermediate filament protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
124	KRT31	interactor	9	0.278	9.474	Filament (PF00038, IPR001664): Intermediate filament protein
125	KRT33B	interactor	3	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein
126	KRT85	interactor	5	0.600	0.994	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
127	LARP1	interactor	14	0.593	8.188	La (PF05383, IPR006630, SM00715): La domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
128	LATS2	suppressor	26	0.190	129.256	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
129	LBR	interactor	7	0.429	3.144	ERG4_ERG24 (PF01222, IPR001171): Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor (PF09465, IPR019023): Lamin-B receptor of TUDOR domain
130	LCA5	interactor	7	0.952	0.286	IncA (PF04156, IPR007285): IncA protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Tantalus (PF15386, IPR028149): Drosophila Tantalus-like Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
131	LDHB	interactor	28	0.365	83.453	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
132	LRRK2	oncoprotein	15	0.462	18.944	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
133	LSR	interactor	5	0.600	0.392	LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR) V-set (PF07686, IPR013106): Immunoglobulin V-set domain
134	LTB4R	interactor	2	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
135	LUC7L2	protein found in more fusions	29	0.328	111.205	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
136	LUC7L3	interactor	9	0.464	3.188	LUC7 (PF03194, IPR004882): LUC7 N_terminus Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
137	MAGOHB	interactor	4	0.833	0.222	Mago_nashi (PF02792, IPR004023): Mago nashi protein
138	MAP3K1	oncoprotein	16	0.419	23.113	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
139	MAP3K2	protein found in more fusions	11	0.644	5.216	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
140	MAP3K3	oncoprotein	8	0.571	2.386	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
141	MAPK7	oncoprotein	16	0.533	13.617	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
142	MARK2	protein found in more fusions	25	0.424	69.680	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
143	MARK3	protein found in more fusions	14	0.833	2.285	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
144	MCFD2	interactor	6	0.467	1.410	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
145	MCM2	oncoprotein	48	0.307	255.164	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
146	MCM3	interactor	17	0.353	19.928	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
147	MDM4	oncoprotein	11	0.711	1.392	zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
148	MEX3B	interactor	6	0.733	0.495	KH_1 (PF00013, IPR004088, SM00322): KH domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
149	MFAP1	interactor	4	0.833	0.143	MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464) SIR4_SID (PF16991, IPR031556): Sir4 SID domain
150	MICALL1	interactor	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain LIM (PF00412, IPR001781, SM00132): LIM domain DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585) FAM70 (PF14967, IPR028014): FAM70 protein
151	MIEF1	protein found in more fusions	2	0	0	Mab-21 (PF03281, IPR024810): Mab-21 protein
152	MPHOSPH9	interactor	6	0.600	1.901	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus IL15 (PF02372, IPR003443): Interleukin 15 Tup_N (PF08581, IPR013890): Tup N-terminal KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
153	MPRIP	interactor	9	0.500	7.063	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 (PF06818): Fez1 FliT (PF05400, IPR008622): Flagellar protein FliT HalX (PF08663, IPR013971): HalX domain Mnd1 (PF03962, IPR005647): Mnd1 family OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57 YlqD (PF11068, IPR021297): YlqD protein DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015) Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
154	MSL2	interactor	3	1.000	0	MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2 zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
155	MST1R	suppressor	9	0.778	0.888	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain
156	MYCBP2	interactor	9	0.639	2.343	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHR (PF08005, IPR012983): PHR domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SH3_3 (PF08239, IPR003646): Bacterial SH3 domain XPA_N (PF01286, IPR022652): XPA protein N-terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
157	MYH10	interactor	10	0.444	7.817	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
158	NADK	interactor	7	0.857	0.458	NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
159	NDEL1	protein found in more fusions	7	0.533	3.156	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
160	NEDD4L	suppressor	22	0.429	50.343	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
161	NEFL	interactor	6	0.400	3.883	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region NOA36 (PF06524, IPR010531): NOA36 protein BORG_CEP (PF14957, IPR029273): Cdc42 effector
162	NOLC1	interactor	16	0.467	19.096	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
163	NOS2	interactor	13	0.455	10.498	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
164	NTRK1	oncoprotein	94	0.152	1988.942	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
165	OPTN	protein found in more fusions	9	0.571	4.323	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
166	OSBPL3	oncoprotein	5	0.600	0.306	Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH_8 (PF15409): Pleckstrin homology domain
167	PABPC1	oncoprotein	31	0.287	113.496	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
168	PABPC4	interactor	24	0.413	44.097	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
169	PAFAH1B1	suppressor	10	0.472	8.344	LisH (PF08513, IPR013720, SM00667): LisH Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
170	PAFAH1B2	oncoprotein	10	0.489	8.910	Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
171	PAK1	oncoprotein	13	0.424	15.050	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
172	PAK2	protein found in more fusions	25	0.333	78.925	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
173	PAK4	protein found in more fusions	16	0.514	14.021	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
174	PARD3	interactor	13	0.577	10.435	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
175	PGD	oncoprotein	11	0.545	7.981	6PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
176	PI4KB	interactor	5	0.600	0.248	PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
177	PIK3C3	interactor	5	0.600	1.543	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
178	PIK3R1	oncoprotein	12	0.418	10.516	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
179	PLA2G12A	interactor	2	1.000	0	PLA2G12 (PF06951, IPR010711): Group XII secretory phospholipase A2 precursor (PLA2G12)
180	POT1	interactor	15	0.341	26.049	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
181	PPARG	suppressor	10	0.417	6.418	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
182	PPFIBP1	oncoprotein	11	0.644	3.252	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
183	PPIG	interactor	6	0.667	1.633	Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
184	PRKCA	interactor	14	0.256	26.836	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
185	PRKCB	suppressor	12	0.273	26.013	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
186	PRKCD	suppressor	13	0.288	23.976	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
187	PRKCG	interactor	5	0.500	1.300	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
188	PRKCQ	interactor	5	0.500	0.786	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
189	PRKCZ	interactor	15	0.495	15.415	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
190	PRPF19	protein found in more fusions	20	0.591	16.016	Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
191	PRPF38B	interactor	2	1.000	0	PRP38 (PF03371, IPR005037): PRP38 family PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
192	PRPF40A	protein found in more fusions	17	0.567	18.588	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
193	PRPF4B	oncoprotein	13	0.423	16.666	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease (PF07168, IPR009834): Ureide permease Pkinase (PF00069, IPR000719): Protein kinase domain Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
194	PTPN3	interactor	5	0.700	0.255	FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
195	PUF60	protein found in more fusions	19	0.464	22.655	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
196	RAB11A	oncoprotein	9	0.333	10.898	Ras (PF00071, IPR001806, SM00173): Ras family
197	RAB11FIP2	protein found in more fusions	9	0.679	4.186	C2 (PF00168, IPR000008, SM00239): C2 domain RBD-FIP (PF09457, IPR019018): FIP domain
198	RABEP1	oncoprotein	7	0.733	1.141	Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major) Rab5-bind (PF09311, IPR015390): Rabaptin-like protein Rabaptin (PF03528, IPR018514): Rabaptin
199	RABGEF1	interactor	6	0.900	0.333	Rho_Binding (PF08912, IPR015008): Rho Binding VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein
200	RACGAP1	interactor	10	0.422	12.650	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
201	RAF1	oncoprotein	23	0.472	39.879	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
202	RAI14	interactor	7	0.762	1.394	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Fez1 (PF06818): Fez1 FliJ (PF02050, IPR012823): Flagellar FliJ protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_13 (PF13166, IPR026866): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
203	RALGPS2	oncoprotein	4	0.833	0.037	PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
204	RASAL2	suppressor	4	0.667	0.451	C2 (PF00168, IPR000008, SM00239): C2 domain FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
205	RASSF2	suppressor	7	0.857	0.384	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
206	RASSF8	suppressor	9	0.556	6.368	ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
207	RBM7	interactor	9	0.500	6.189	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
208	RMDN3	interactor	5	0.800	0.139	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_16 (PF13432): Tetratricopeptide repeat
209	RNPS1	interactor	24	0.366	69.385	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
210	SAMD4A	interactor	3	0.667	0.054	PHAT (PF09246, IPR015327): PHAT SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
211	SAMD4B	interactor	7	0.571	2.450	PHAT (PF09246, IPR015327): PHAT SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
212	SAMSN1	interactor	7	0.857	0.135	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
213	SF3B3	interactor	25	0.453	46.000	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
214	SFN	suppressor	68	0.109	973.785	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
215	SH3BP4	protein found in more fusions	5	0.833	0.043	SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
216	SH3BP5L	interactor	1	0	0	SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5) DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
217	SHCBP1	interactor	5	0.700	2.333	Methyltransf_10 (PF05971, IPR010286): Protein of unknown function (DUF890) DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408) Pectate_lyase_3 (PF12708, IPR024535): Pectate lyase superfamily protein Beta_helix (PF13229): Right handed beta helix region
218	SIMC1	interactor	2	1.000	0	FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
219	SKP1	oncoprotein	23	0.285	72.967	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
220	SMARCD1	interactor	8	0.321	10.183	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
221	SNAP23P1	interactor	1	0	0	NA
222	SNRNP200	protein found in more fusions	25	0.467	37.092	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603 Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
223	SON	interactor	11	0.527	7.431	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
224	SRGAP2	interactor	5	0.800	0.619	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) KIP1 (PF07765, IPR011684): KIP1-like protein RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF2987 (PF11205, IPR021370): Protein of unknown function (DUF2987)
225	SRRM1	interactor	21	0.486	33.494	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
226	SRRM2	interactor	37	0.353	145.483	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
227	SRSF10	interactor	10	0.644	3.223	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
228	SRSF3	oncoprotein	19	0.427	31.090	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
229	SS18	oncoprotein	7	0.600	2.536	SSXT (PF05030, IPR007726): SSXT protein (N-terminal region) Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
230	SSFA2	interactor	7	0.619	3.960	KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
231	SYNPO	interactor	9	0.417	10.448	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
232	SYNPO2	suppressor	4	0.833	0.143	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
233	TBC1D1	interactor	3	1.000	0	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) IncA (PF04156, IPR007285): IncA protein PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350) FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
234	TERF1	interactor	23	0.203	95.475	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
235	TESPA1	interactor	3	1.000	0	PUB (PF09409, IPR018997): PUB domain DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain
236	TGM2	protein found in more fusions	19	0.444	34.027	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
237	THRAP3	oncoprotein	19	0.322	49.371	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
238	TIAM1	oncoprotein	11	0.273	21.158	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain AAA_22 (PF13401, IPR003593): AAA domain
239	TINF2	interactor	9	0.571	5.575	TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
240	TJP2	oncoprotein	12	0.439	12.356	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
241	TMEM102	interactor	1	0	0	Mab-21 (PF03281, IPR024810): Mab-21 protein
242	TNFAIP3	suppressor	9	0.750	0.555	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
243	TNK1	suppressor	8	0.857	0.135	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
244	TRA2A	interactor	23	0.474	46.451	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
245	TRA2B	interactor	15	0.457	15.904	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
246	TRIM21	interactor	11	0.622	3.212	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
247	TRIM32	suppressor	14	0.615	7.922	NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
248	TSC1	suppressor	8	0.571	4.103	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
249	TUBA3C	interactor	9	0.861	0.497	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
250	TXNDC5	interactor	11	0.582	6.059	Thioredoxin (PF00085, IPR013766): Thioredoxin
251	UBC	protein found in more fusions	48	0.213	413.006	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
252	UBE2R2	protein found in more fusions	9	0.536	2.342	NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
253	UBE2V1	interactor	11	0.582	6.865	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
254	UBFD1	interactor	10	0.622	3.798	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
255	UNK	interactor	18	0.340	33.610	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
256	USP37	interactor	12	0.436	12.675	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
257	USP8	interactor	14	0.551	13.754	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain SET (PF00856, IPR001214, SM00317): SET domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
258	VCL	oncoprotein	20	0.503	28.320	Vinculin (PF01044, IPR006077): Vinculin family
259	VCP	protein found in more fusions	52	0.292	333.057	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
260	VIM	suppressor	29	0.341	101.923	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
261	WDR62	interactor	8	0.857	0.651	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
262	WNK1	interactor	12	0.673	3.221	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
263	WWC1	interactor	16	0.375	26.245	APG6 (PF04111, IPR007243): Autophagy protein Apg6 bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein WW (PF00397, IPR001202, SM00456): WW domain
264	WWTR1	interactor	8	0.571	2.728	WW (PF00397, IPR001202, SM00456): WW domain
265	XPO1	interactor	59	0.148	769.002	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
266	YAP1	suppressor	18	0.464	33.427	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
267	YWHAB	interactor	135	0.090	4532.974	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
268	YWHAE	oncoprotein	130	0.099	4102.487	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
269	YWHAH	protein found in more fusions	86	0.149	1366.359	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
270	YWHAQ	interactor	123	0.105	3444.607	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
271	YWHAZ	protein found in more fusions	133	0.105	4109.011	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
272	ZBTB21	protein found in more fusions	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Mut7-C (PF01927, IPR002782): Mut7-C RNAse domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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