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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins XRCC4 (from a repository: Thu Jul 11 22:46:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins10 (27.78 %)
The number (and %) of the tumor suppressors6 (16.67 %)
Total number of binary PPIs (saturation %)90 (14.29 %)
The number (and %) of affected PPIs36 (40.00 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI4.056
Assortativity coefficient-0.5694
The network average Clustering coefficient0.426
The number (and %) of a zero Clustering coefficients15 (41.67 %)
The number (and %) of a zero Betweenness Centrality23 (63.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: XRCC4 All fusions
Proteins found in more fusions NF2 (see 1 fusions); CSNK2A1 (see 2 fusions); CHD3 (see 1 fusions); ACTN1 (see 3 fusions); VIM (see 1 fusions); NUDT21 (see 2 fusions); PRKDC (see 2 fusions); NFKB1 (see 2 fusions); DDX5 (see 1 fusions); XRCC4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 XRCC4parental protein360.0641030.667XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
2 ACTN1protein found in more fusions200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ALDH7A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 APLFinteractor41.0000HUN (PF08729, IPR014840): HPC2 and ubinuclein domain
Pox_RNA_Pol_19 (PF05320, IPR007984): Poxvirus DNA-directed RNA polymerase 19 kDa subunit
zf-CCHH (PF10283, IPR019406): Zinc-finger (CX5CX6HX5H) motif
FAM176 (PF14851): FAM176 family
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
5 APPBP2interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
6 APTXinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
7 ASTE1interactor100XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
XPG_I_2 (PF12813): XPG domain containing
8 BIN1suppressor41.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
9 CAAP1interactor100Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
CAAP1 (PF15335): Caspase activity and apoptosis inhibitor 1
10 CALM1interactor30.6670.500EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 CHD3oncoprotein50.5002.500CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
12 CSNK2A1oncoprotein70.5336.000Pkinase (PF00069, IPR000719): Protein kinase domain
13 CWC27interactor21.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
14 DDX5oncoprotein60.5004.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 DENRoncoprotein100SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
16 ERGoncoprotein50.8001.333Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
17 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
18 IFFO1interactor100Filament (PF00038, IPR001664): Intermediate filament protein
19 IFFO2interactor100Filament (PF00038, IPR001664): Intermediate filament protein
HIN (PF02760, IPR004021): HIN-200/IF120x domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
20 LIG4interactor70.6676.000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
21 LONRF2interactor100BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
22 MED4interactor21.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
23 NBNsuppressor40.6672.000FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
24 NF2suppressor51.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
25 NFKB1suppressor200Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
26 NHEJ1interactor21.0000XLF (PF09302, IPR015381): XLF-Cernunnos, XRcc4-like factor, NHEJ component
27 NUDT21protein found in more fusions31.0000NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
28 PNKPinteractor60.8671.000PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
29 PRKDCprotein found in more fusions120.40027.667FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
30 SETMARinteractor200Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
Transposase_1 (PF01359, IPR001888): Transposase (partial DDE domain)
HTH_Tnp_Tc3_2 (PF01498, IPR002492): Transposase
DDE_3 (PF13358): DDE superfamily endonuclease
HTH_32 (PF13565): Homeodomain-like domain
31 SRP54interactor31.00005_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
SRP_SPB (PF02978, IPR004125): Signal peptide binding domain
YlbD_coat (PF14071, IPR025953): Putative coat protein
32 USP7oncoprotein200MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
33 VIMsuppressor40.6671.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
34 VPS41interactor100Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
35 XRCC5suppressor120.47318.833Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
36 XRCC6oncoprotein110.53312.500Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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