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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins XBP1 (from a repository: Sat Dec 3 11:00:17 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins7 (25.00 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)61 (16.14 %)
The number (and %) of affected PPIs28 (45.90 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.500
Assortativity coefficient-0.3541
The network average Clustering coefficient0.656
The number (and %) of a zero Clustering coefficients5 (17.86 %)
The number (and %) of a zero Betweenness Centrality18 (64.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: XBP1 All fusions
: AW956952;
Proteins found in more fusions MCM2 (see 1 fusions); XBP1 (see 2 fusions); FOS (see 4 fusions); KAT2B (see 1 fusions); CREBZF (see 1 fusions); SRSF1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 XBP1parental protein280.063632.000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
2 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
3 ATF6Binteractor40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
4 CREBZFprotein found in more fusions31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
5 DERL1interactor40.6671.000DER1 (PF04511, IPR007599): Der1-like family
6 ESR1suppressor70.4677.667Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
7 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 FUBP3interactor21.0000DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
9 GLI1suppressor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
10 H1F0interactor21.0000OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
11 H1FXinteractor21.0000IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
12 HDGFinteractor50.4005.667PWWP (PF00855, IPR000313, SM00293): PWWP domain
13 HM13interactor21.0000Peptidase_A22B (PF04258, IPR007369): Signal peptide peptidase
DUF4345 (PF14248, IPR025597): Domain of unknown function (DUF4345)
14 KAT2Ainteractor40.6670.667Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
15 KAT2Bprotein found in more fusions31.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
16 MCM2oncoprotein50.5003.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
17 NR0B2suppressor21.0000Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18 PCBD2interactor100Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
19 PSMA5oncoprotein31.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
20 PSMA6interactor31.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 PSMA8interactor40.6672.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
22 RBL2suppressor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
23 SRSF1protein found in more fusions50.6671.667Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
24 SSX4oncoprotein100KRAB (PF01352, IPR001909, SM00349): KRAB box
SSXRD (PF09514, IPR019041): SSXRD motif
25 TRIP4interactor21.0000ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
26 UBE2Iinteractor60.6003.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
27 ZNF440interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
28 ZNF580interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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