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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins17 (23.29 %)
The number (and %) of the tumor suppressors19 (26.03 %)
Total number of binary PPIs (saturation %)253 (9.63 %)
The number (and %) of affected PPIs73 (28.85 %)
The number of possible different fusions19
PPI diameter2
PPI radius1
The average degree of PPI5.945
Assortativity coefficient-0.2818
The network average Clustering coefficient0.630
The number (and %) of a zero Clustering coefficients8 (10.96 %)
The number (and %) of a zero Betweenness Centrality28 (38.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: WWP1 All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); UBE2D2 (see 2 fusions); ATN1 (see 1 fusions); TRAF6 (see 1 fusions); EWSR1 (see 2 fusions); EZH2 (see 1 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); SMAD4 (see 2 fusions); UBC (see 1 fusions); SFTPC (see 1 fusions); TRAF4 (see 1 fusions); LZTR1 (see 2 fusions); EZR (see 2 fusions); HSP90AA1 (see 2 fusions); SMAD3 (see 3 fusions); WWP1 (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 WWP1parental protein730.0573957.490C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
2 ARRDC1interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3 ARRDC2interactor100Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 ARRDC3interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ASH2Linteractor200SPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
6 ATN1protein found in more fusions50.8330.667Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
7 CDK8interactor70.7333.333Pkinase (PF00069, IPR000719): Protein kinase domain
8 CPSF6interactor50.7002.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
9 DAZAP2protein found in more fusions40.6671.000DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
10 DIDO1suppressor21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
SlyX (PF04102, IPR007236): SlyX
SPOC (PF07744, IPR012921): SPOC domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
11 DVL2interactor50.6672.000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
12 ERBB4suppressor40.6670.667Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 ESR2suppressor60.4005.167zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
14 EWSR1oncoprotein80.42910.286RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 EZH2suppressor70.4008.333CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
16 EZRprotein found in more fusions200DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
17 FAM189A2interactor31.0000CD20 (PF04103, IPR007237): CD20-like family
18 FAM189Binteractor31.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
19 FBXL15interactor30.6670.667LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
20 FBXL18interactor40.5002.667LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
21 H2AFY2interactor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
22 HIVEP3suppressor30.6670.667Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
23 HSP90AA1oncoprotein110.20034.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
24 HSPB1oncoprotein70.3338.167HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
25 IKBKGinteractor70.4676.786CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
26 ITCHinteractor360.111506.871C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 KLF2interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
28 KLF5suppressor50.7002.333zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
29 LAPTM5oncoprotein31.0000Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
30 LATS1suppressor40.6671.000Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
31 LDLRAD4interactor41.0000Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
32 LITAFsuppressor30.6671.000zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
33 LNX1interactor50.5003.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
34 LZTR1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
35 NOTCH1suppressor50.6671.333Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
36 PCBD1interactor40.6671.000Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
37 PHF20L1interactor21.0000MBT (PF02820, IPR004092, SM00561): mbt repeat
PHD (PF00628, IPR019787, SM00249): PHD-finger
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PEHE (PF15275, IPR029332): PEHE domain
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
38 PRKAA2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
39 PTCH1suppressor21.0000Patched (PF02460, IPR003392): Patched family
40 PTENsuppressor80.39312.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
41 PTPN14oncoprotein40.8330.500FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
42 RNF11protein found in more fusions100.47214.419zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
43 RTN4suppressor200CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
44 RUNX2suppressor70.5718.667DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
45 SCNN1Ainteractor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
46 SETD4interactor100Rubis-subs-bind (PF09273, IPR015353): Rubisco LSMT substrate-binding
SET (PF00856, IPR001214, SM00317): SET domain
47 SFTPCprotein found in more fusions200BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
48 SKILsuppressor61.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
49 SMAD1interactor120.58212.952MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
50 SMAD2suppressor140.52619.571MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
51 SMAD3oncoprotein150.42935.119MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
52 SMAD4suppressor120.50918.252MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
53 SMAD5interactor80.7862.486MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
54 SMAD6interactor70.8101.452MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
55 SMAD7interactor80.7144.571MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
56 SPG20interactor31.0000MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
57 STAT6oncoprotein30.6671.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal
58 TMEM255Ainteractor21.0000FAM70 (PF14967, IPR028014): FAM70 protein
59 TMEM255Binteractor100FAM70 (PF14967, IPR028014): FAM70 protein
60 TMEM51interactor21.0000WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
TMEM51 (PF15345, IPR029265): Transmembrane protein 51
61 TP63suppressor50.8330.667Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
62 TRAF4oncoprotein40.6671.000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
63 TRAF6protein found in more fusions100.55611.300SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
64 UBCprotein found in more fusions190.25597.752ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65 UBE2D1interactor80.7622.286UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
66 UBE2D2oncoprotein90.6797.119UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
67 UBE2D3interactor60.9000.286UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
68 UBE2L3interactor80.6674.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
69 WBP1interactor21.0000WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
70 WBP2interactor21.0000GRAM (PF02893, IPR004182, SM00568): GRAM domain
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
71 XRCC5suppressor50.5002.667Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
72 YWHAQinteractor40.5002.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
73 ZNF638interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-met (PF12874): Zinc-finger of C2H2 type
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus

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