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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MT1G, WNK4 (from a repository: Sun Mar 19 05:18:58 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins6 (42.86 %)
The number (and %) of the tumor suppressors2 (14.29 %)
Total number of binary PPIs (saturation %)34 (37.36 %)
The number (and %) of affected PPIs12 (35.29 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI3.429
Assortativity coefficient0.2454
The network average Clustering coefficient0.488
The number (and %) of a zero Clustering coefficients4 (28.57 %)
The number (and %) of a zero Betweenness Centrality6 (42.86 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: WNK4,MT1G All fusions
: DD229468; DI093562; H91370;
Proteins found in more fusions BCL6 (see 2 fusions); CUL3 (see 1 fusions); NEDD4L (see 3 fusions); HSP90AA1 (see 2 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 WNK4parental protein100.26748.667Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
2 MT1Gparental protein202.000Metallothio (PF00131, IPR003019): Metallothionein
3 AKT1oncoprotein40.6670.667PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 BCL6oncoprotein41.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
5 CUL3protein found in more fusions70.4008.333Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 HSP90AA1oncoprotein60.5004.333HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
7 KLHL2interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
8 KLHL3interactor40.6670.667BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
9 NEDD4Lsuppressor41.0000WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
10 SGK1oncoprotein50.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
11 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
12 SPINK7suppressor100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
13 STK39interactor200BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
14 YWHAQinteractor40.6671.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MT1Gparental proteinMetallothio (PF00131, IPR003019): MetallothioneinDD229468, DI093562, H91370
2 SHBGoncoproteinLaminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
DD229468, DI093562, H91370
3 SPINK7suppressorKazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domainDD229468, DI093562, H91370
4 WNK4parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DD229468, DI093562, H91370

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