Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VPS4A (from a repository: Mon Dec 5 23:42:02 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins4 (15.38 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)66 (20.31 %)
The number (and %) of affected PPIs26 (39.39 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI4.231
Assortativity coefficient-0.5401
The network average Clustering coefficient0.428
The number (and %) of a zero Clustering coefficients10 (38.46 %)
The number (and %) of a zero Betweenness Centrality14 (53.85 %)


List of the fusions

PPI for parental proteins: VPS4A All fusions
: BQ334182;
Proteins found in more fusions VPS4A (see 1 fusions); CHMP1A (see 2 fusions); CENPQ (see 1 fusions); CHMP3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 VPS4Aparental protein260.100489.800AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
2 ARL8Binteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
3 ATP1A3interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 BABAM1interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
5 CENPQprotein found in more fusions200CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
6 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 CHMP1Aprotein found in more fusions60.8000.833Snf7 (PF03357, IPR005024): Snf7
8 CHMP1Binteractor80.5715.067Snf7 (PF03357, IPR005024): Snf7
9 CHMP2Ainteractor60.7001.333Snf7 (PF03357, IPR005024): Snf7
10 CHMP3protein found in more fusions70.6003.233Snf7 (PF03357, IPR005024): Snf7
11 CHMP4Ainteractor70.6003.233Snf7 (PF03357, IPR005024): Snf7
12 CHMP4Binteractor100.50010.800Snf7 (PF03357, IPR005024): Snf7
13 CHMP4Cinteractor50.8330.400Snf7 (PF03357, IPR005024): Snf7
14 CHMP5interactor70.6002.900Snf7 (PF03357, IPR005024): Snf7
15 FBXO6interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 HGSinteractor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
17 IST1interactor50.8000.833Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
18 KCND3interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3399 (PF11879, IPR024587): Domain of unknown function (DUF3399)
19 KMT2Einteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
21 NPC1interactor21.0000Patched (PF02460, IPR003392): Patched family
VirB3 (PF05101, IPR007792): Type IV secretory pathway, VirB3-like protein
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
NPC1_N (PF16414, IPR032190): Niemann-Pick C1 N terminus
22 RHEBoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
23 TMEM248interactor100TMEM219 (PF14940): Transmembrane 219
24 VPS4Binteractor90.33320.167AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
25 VTA1interactor50.7001.400Vta1 (PF04652): Vta1 like
26 ZFYVE19interactor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger

B a c k    t o    T o p ⇑