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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VPS4A (from a repository: Mon Dec 5 23:42:02 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins4 (15.38 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)66 (20.31 %)
The number (and %) of affected PPIs26 (39.39 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI4.231
Assortativity coefficient-0.5401
The network average Clustering coefficient0.428
The number (and %) of a zero Clustering coefficients10 (38.46 %)
The number (and %) of a zero Betweenness Centrality14 (53.85 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS4A All fusions
: BQ334182;
Proteins found in more fusions VPS4A (see 1 fusions); CHMP1A (see 2 fusions); CENPQ (see 1 fusions); CHMP3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS4Aparental protein260.100489.800AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
2 ARL8Binteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
3 ATP1A3interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 BABAM1interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
5 CENPQprotein found in more fusions200CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
6 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 CHMP1Aprotein found in more fusions60.8000.833Snf7 (PF03357, IPR005024): Snf7
8 CHMP1Binteractor80.5715.067Snf7 (PF03357, IPR005024): Snf7
9 CHMP2Ainteractor60.7001.333Snf7 (PF03357, IPR005024): Snf7
10 CHMP3protein found in more fusions70.6003.233Snf7 (PF03357, IPR005024): Snf7
11 CHMP4Ainteractor70.6003.233Snf7 (PF03357, IPR005024): Snf7
12 CHMP4Binteractor100.50010.800Snf7 (PF03357, IPR005024): Snf7
13 CHMP4Cinteractor50.8330.400Snf7 (PF03357, IPR005024): Snf7
14 CHMP5interactor70.6002.900Snf7 (PF03357, IPR005024): Snf7
15 FBXO6interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 HGSinteractor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
17 IST1interactor50.8000.833Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
18 KCND3interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3399 (PF11879, IPR024587): Domain of unknown function (DUF3399)
19 KMT2Einteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
21 NPC1interactor21.0000Patched (PF02460, IPR003392): Patched family
VirB3 (PF05101, IPR007792): Type IV secretory pathway, VirB3-like protein
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
NPC1_N (PF16414, IPR032190): Niemann-Pick C1 N terminus
22 RHEBoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
23 TMEM248interactor100TMEM219 (PF14940): Transmembrane 219
24 VPS4Binteractor90.33320.167AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
25 VTA1interactor50.7001.400Vta1 (PF04652): Vta1 like
26 ZFYVE19interactor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger

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