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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VPS39 (from a repository: Mon Dec 5 12:47:25 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins2 (11.76 %)
The number (and %) of the tumor suppressors5 (29.41 %)
Total number of binary PPIs (saturation %)35 (25.74 %)
The number (and %) of affected PPIs17 (48.57 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.294
Assortativity coefficient-0.5150
The network average Clustering coefficient0.630
The number (and %) of a zero Clustering coefficients4 (23.53 %)
The number (and %) of a zero Betweenness Centrality13 (76.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS39 All fusions
: BE816198;
Proteins found in more fusions VPS39 (see 1 fusions); STAT3 (see 2 fusions); HOOK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS39parental protein170.100196.667CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
2 AP3D1interactor21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AP3D1 (PF06375): AP-3 complex subunit delta-1
3 CDK2suppressor31.0000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
5 HOOK1protein found in more fusions200HOOK (PF05622, IPR008636): HOOK protein
6 NOTCH1suppressor41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
7 NTRK1oncoprotein60.4006.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
8 RAB7Asuppressor40.8330.667Ras (PF00071, IPR001806, SM00173): Ras family
9 RILPinteractor31.0000NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
10 STAT3suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
11 STX17interactor21.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
Gly-zipper_YMGG (PF13441, IPR027367): YMGG-like Gly-zipper
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
12 UAP1interactor200UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
13 UBXN6interactor21.0000PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
14 UVRAGsuppressor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
HTH_1 (PF00126, IPR000847): Bacterial regulatory helix-turn-helix protein, lysR family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
15 VIPAS39interactor100Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
16 VPS11interactor70.38112.667DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
17 XPO6interactor21.0000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein

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