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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VEGFA (from a repository: Sun Dec 4 16:59:14 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins12 (48.00 %)
The number (and %) of the tumor suppressors4 (16.00 %)
Total number of binary PPIs (saturation %)50 (16.67 %)
The number (and %) of affected PPIs25 (50.00 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.360
Assortativity coefficient-0.4110
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients8 (32.00 %)
The number (and %) of a zero Betweenness Centrality12 (48.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VEGFA All fusions
: BF340246;
Proteins found in more fusions VPS35 (see 2 fusions); HNRNPD (see 1 fusions); HSP90AA1 (see 2 fusions); HNRNPL (see 2 fusions); VEGFA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VEGFAparental protein250.065490.500PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
VEGF_C (PF14554, IPR027928): VEGF heparin-binding domain
2 ADAMTS1oncoprotein100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 CRYABoncoprotein31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
4 CTGFsuppressor21.0000Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
5 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 FLT1oncoprotein40.5002.000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
7 GPC1interactor100Glypican (PF01153, IPR001863): Glypican
8 HGSinteractor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
9 HNRNPDoncoprotein50.5003.000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 HNRNPLprotein found in more fusions50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 HSP90AA1oncoprotein40.6671.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
12 HSPA4interactor40.5003.000Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
13 IGFBP7suppressor100IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ig_3 (PF13927): Immunoglobulin domain
14 ILF3oncoprotein40.5003.000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
15 KDRoncoprotein30.6670.500Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt)
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
16 LYVE1interactor100Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
BtrH_N (PF14399, IPR026935): Butirosin biosynthesis protein H, N-terminal
17 NRP1interactor50.4005.000CUB (PF00431, IPR000859, SM00042): CUB domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF3481 (PF11980, IPR022579): C-terminal domain of neuropilin glycoprotein
18 PGFoncoprotein40.6670.500PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
19 PRRG4interactor100Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
20 SPARCsuppressor100FOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
21 U2AF1oncoprotein100DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
22 UBIAD1suppressor100UbiA (PF01040, IPR000537): UbiA prenyltransferase family
23 VEGFBinteractor30.6670.500PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
24 VPS35protein found in more fusions40.6671.000FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
25 VTNinteractor21.0000Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain

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