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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VAC14 (from a repository: Mon Nov 14 04:07:21 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins13 (20.31 %)
The number (and %) of the tumor suppressors2 (3.12 %)
Total number of binary PPIs (saturation %)112 (5.56 %)
The number (and %) of affected PPIs64 (57.14 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI2.938
Assortativity coefficient-0.5258
The network average Clustering coefficient0.335
The number (and %) of a zero Clustering coefficients36 (56.25 %)
The number (and %) of a zero Betweenness Centrality53 (82.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VAC14 All fusions
Proteins found in more fusions EIF4A2 (see 2 fusions); MTMR9 (see 1 fusions); RBFOX2 (see 2 fusions); APP (see 4 fusions); EGFR (see 2 fusions); SRPK2 (see 1 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VAC14parental protein640.0163759.167TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
2 ACSS1interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
ACAS_N (PF16177, IPR032387): Acetyl-coenzyme A synthetase N-terminus
3 APPprotein found in more fusions80.28614.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARL13Binteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
5 ASB13interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 BHLHE40interactor200Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
7 BSGinteractor21.0000Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
8 C11orf54interactor21.0000DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
9 C4orf33interactor100NA
10 CASP1oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CCDC103interactor100RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Dynein_attach_N (PF15867, IPR031733): Dynein attachment factor N-terminus
12 CD209interactor200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
13 CD274oncoprotein100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
14 CDRT4interactor100CDRT4 (PF15213, IPR029185): CMT1A duplicated region transcript 4 protein
15 COL8A1interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
16 CRKoncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 DDAH2interactor100Amidinotransf (PF02274, IPR003198): Amidinotransferase
18 EGFRoncoprotein70.4677.167Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
19 EIF4A2oncoprotein200DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20 FIG4interactor21.0000Syja_N (PF02383, IPR002013): SacI homology domain
21 FNDC3Binteractor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
22 GNAI2oncoprotein100G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
23 JMJD7interactor100Cupin_8 (PF13621): Cupin-like domain
24 KRTAP19-5interactor30.6671.000KRTAP (PF11759, IPR021743): Keratin-associated matrix
25 KRTAP19-7interactor21.0000KRTAP (PF11759, IPR021743): Keratin-associated matrix
26 KYAT1interactor21.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
27 LINC00518interactor100NA
28 LPAL2interactor100NA
29 LSM4interactor40.5003.000LSM (PF01423, IPR001163): LSM domain
30 MGAT5Binteractor21.0000Glyco_transf_18 (PF15024): Glycosyltransferase family 18
31 MICAinteractor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
32 MPPED2interactor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
33 MTMR9protein found in more fusions31.0000Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
34 MVPoncoprotein31.0000Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
35 NEURL4interactor100Neuralized (PF07177, IPR006573, SM00588): Neuralized
36 NGBinteractor100Globin (PF00042, IPR000971): Globin
37 NTRK1oncoprotein110.22234.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
38 PARP16interactor100PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
39 PCMTD2interactor100PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
SOCS_box (PF07525, IPR001496): SOCS box
40 PDE4DIPoncoprotein100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
41 PELI1interactor21.0000Pellino (PF04710, IPR006800): Pellino
42 PFASinteractor21.0000AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
43 PHF1interactor100PHD (PF00628, IPR019787, SM00249): PHD-finger
Mtf2_C (PF14061, IPR025894): Polycomb-like MTF2 factor 2
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
44 PHKA1interactor100Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
45 PHYKPLinteractor200Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
46 PIKFYVEinteractor40.5002.500Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
47 PPIP5K1interactor21.0000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
48 PPIP5K2interactor21.0000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
49 PPP2CAsuppressor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
50 PRADC1interactor100PA (PF02225, IPR003137): PA domain
51 PRR13interactor200DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
52 PRR20Ainteractor200PRR20 (PF15708, IPR031439): Proline-rich protein family 20
53 RBFOX2protein found in more fusions50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
54 RHOXF2interactor70.33310.000DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
55 SIGLEC5interactor200V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
56 SMUG1interactor100UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
57 SNF8interactor200EAP30 (PF04157, IPR007286): EAP30/Vps36 family
58 SPRYD7interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
59 SRPK2oncoprotein50.5002.500DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
60 TCEANCinteractor21.0000Ribosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
61 TP53BP1suppressor10053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
62 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
63 XPO1interactor60.4677.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
64 ZNF34interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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