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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins7 (17.95 %)
The number (and %) of the tumor suppressors6 (15.38 %)
Total number of binary PPIs (saturation %)111 (14.98 %)
The number (and %) of affected PPIs39 (35.14 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.769
Assortativity coefficient-0.3035
The network average Clustering coefficient0.525
The number (and %) of a zero Clustering coefficients10 (25.64 %)
The number (and %) of a zero Betweenness Centrality20 (51.28 %)


List of the fusions

PPI for parental proteins: USP25 All fusions
Proteins found in more fusions MYO6 (see 3 fusions); SENP1 (see 1 fusions); APP (see 4 fusions); SYK (see 1 fusions); CUL3 (see 1 fusions); USP25 (see 1 fusions); UBC (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 USP25parental protein390.0781124.233UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UBA_4 (PF14555): UBA-like domain
2 ACTA1interactor100Actin (PF00022, IPR004000, SM00268): Actin
3 ANXA1suppressor50.6671.667Annexin (PF00191, IPR018502, SM00335): Annexin
4 APPprotein found in more fusions70.4008.067APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BTBD9interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
6 CDC37L1interactor31.0000CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
7 CROTinteractor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
8 CUL2suppressor60.7332.500Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 CUL3protein found in more fusions150.30854.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 FLNCinteractor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
11 GAPDHoncoprotein70.6005.000Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
12 HSP90B1suppressor50.6004.000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
13 KCTD10interactor50.8001.333BTB_2 (PF02214, IPR003131): BTB/POZ domain
14 KCTD13interactor50.8330.667BTB_2 (PF02214, IPR003131): BTB/POZ domain
15 KIAA1468interactor31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
HEAT (PF02985, IPR000357): HEAT repeat
Nuc_H_symport (PF03825): Nucleoside H+ symporter
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4128 (PF13554, IPR025395): Bacteriophage related domain of unknown function
HEAT_2 (PF13646): HEAT repeats
16 KLHL13interactor40.8330.500BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
17 KLHL9interactor40.8330.500BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
18 KRT4interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
19 LYZinteractor100Lys (PF00062, IPR001916, SM00263): C-type lysozyme/alpha-lactalbumin family
20 MAGEB4interactor100MAGE (PF01454, IPR002190): MAGE family
Pap_E4 (PF02711, IPR003861): E4 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
21 MT2Asuppressor100Metallothio (PF00131, IPR003019): Metallothionein
22 MYBPC1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
23 MYO6protein found in more fusions41.0000BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
24 NEDD8interactor100.50012.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 PIPinteractor100SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
26 RAD23Aoncoprotein50.8330.667UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27 SENP1protein found in more fusions60.4003.500Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
28 SKILsuppressor31.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
29 SONinteractor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
G-patch (PF01585, IPR000467, SM00443): G-patch domain
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
RSRP (PF17069): Arginine/Serine-Rich protein 1
30 SUMO1interactor50.5001.400Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
31 SUMO2interactor70.4676.400Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
32 SUMO3interactor60.4676.067Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
33 SYKsuppressor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
34 UBCprotein found in more fusions140.28251.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
35 UBE2Iinteractor80.33311.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 USP28interactor41.0000TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
37 WRNIP1interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
38 ZG16Binteractor100Jacalin (PF01419, IPR001229, SM00915): Jacalin-like lectin domain
39 ZNF426interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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