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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins11 (17.19 %)
The number (and %) of the tumor suppressors3 (4.69 %)
Total number of binary PPIs (saturation %)164 (8.13 %)
The number (and %) of affected PPIs64 (39.02 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.406
Assortativity coefficient-0.4998
The network average Clustering coefficient0.508
The number (and %) of a zero Clustering coefficients21 (32.81 %)
The number (and %) of a zero Betweenness Centrality41 (64.06 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: USP20 All fusions
: AA393366;
Proteins found in more fusions NUP153 (see 2 fusions); ALAS1 (see 1 fusions); TRAF6 (see 1 fusions); FECH (see 1 fusions); USP20 (see 1 fusions); VHL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 USP20parental protein640.0403554.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
2 ACADMoncoprotein21.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
3 ADRB2interactor60.5004.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ALAS1protein found in more fusions31.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
5 APBA2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
6 ATAD3Binteractor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
7 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
8 BEND5interactor100LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
T4SS (PF07996, IPR014158): Type IV secretion system proteins
BEN (PF10523, IPR018379, SM01025): BEN domain
9 BEND7interactor200BEN (PF10523, IPR018379, SM01025): BEN domain
10 CALM1interactor80.32117.500EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 CBX7interactor21.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
12 CCDC36interactor100DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
13 CCP110interactor50.7002.000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
14 DBNLinteractor41.0000RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
15 DIO2oncoprotein31.0000T4_deiodinase (PF00837, IPR000643): Iodothyronine deiodinase
16 ECI2interactor51.0000ACBP (PF00887, IPR000582): Acyl CoA binding protein
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
17 EIF3Concoprotein40.8330.500eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
18 EIF3Eoncoprotein40.6671.167eIF3_N (PF09440, IPR019010): eIF3 subunit 6 N terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
19 FATE1interactor100Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
20 FECHprotein found in more fusions200Ferrochelatase (PF00762, IPR001015): Ferrochelatase
21 GPT2interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
22 HERC2interactor110.35626.500ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
23 HERC2P2interactor100NA
24 HIF1Asuppressor30.6670.667Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
25 LRRC59interactor100Hid1 (PF12722): High-temperature-induced dauer-formation protein
LRR_8 (PF13855, IPR001611): Leucine rich repeat
DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
26 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
27 MAP7D1interactor21.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
28 MDFIinteractor41.0000MDFI (PF15316, IPR026134): MyoD family inhibitor
29 MYO1Ainteractor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
30 MYO1Cinteractor21.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
31 N4BP3interactor100Fez1 (PF06818): Fez1
YqzE (PF14038, IPR025622): YqzE-like protein
32 NEURL4interactor70.5249.000Neuralized (PF07177, IPR006573, SM00588): Neuralized
33 NUP153protein found in more fusions31.0000Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
34 PJA1interactor41.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
35 PLA2G2Aoncoprotein51.0000Phospholip_A2_1 (PF00068, IPR016090, SM00085): Phospholipase A2
36 PLECinteractor100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
S10_plectin (PF03501, IPR005326): Plectin/S10 domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
YlqD (PF11068, IPR021297): YlqD protein
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
37 PLEKHA7interactor100OGG_N (PF07934, IPR012904): 8-oxoguanine DNA glycosylase, N-terminal domain
PH (PF00169, IPR001849, SM00233): PH domain
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
WW (PF00397, IPR001202, SM00456): WW domain
AAA_23 (PF13476): AAA domain
38 PLK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
39 POLDIP3interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 PRKACAinteractor40.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
41 PSMD11interactor70.4769.667DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
42 PSMD12interactor80.4769.000Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
43 PSMD6interactor41.0000RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
44 PSMD7interactor70.5717.333JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
45 RAD17interactor50.7003.000Mvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
46 RFC2interactor41.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_16 (PF13191): AAA ATPase domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
47 RFC3interactor41.0000CHB_HEX (PF03173, IPR004866, SM01081): Putative carbohydrate binding domain
DNA_pol3_delta (PF06144, IPR010372): DNA polymerase III, delta subunit
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
DNA_pol3_delta2 (PF13177): DNA polymerase III, delta subunit
48 RFC4interactor41.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
49 RGPD5interactor21.0000GRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
50 SPRY2suppressor41.0000KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
51 SUN2interactor100Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
MRP (PF09387, IPR018539): Mitochondrial RNA binding protein MRP
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
RsbRD_N (PF14361, IPR025751): RsbT co-antagonist protein rsbRD N-terminal domain
CLZ (PF16526, IPR032406): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
52 SYTL4interactor100AreA_N (PF07573, IPR011420): Nitrogen regulatory protein AreA N terminus
C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
53 TRAF6protein found in more fusions80.5248.500SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
54 TRIM23interactor31.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
55 UCHL3interactor70.7332.500Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
56 USP15oncoprotein100.52813.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
57 USP21interactor80.6196.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
58 USP28interactor80.6674.667TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
59 USP33suppressor120.28845.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
60 VAPAinteractor40.6671.500DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
61 VAPBinteractor50.6003.333ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
62 VHLoncoprotein90.35717.167Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
63 VSX2interactor21.0000OAR (PF03826, IPR003654): OAR domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
64 ZNF770interactor100IL3 (PF02059, IPR002183): Interleukin-3
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)

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