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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins USP16 (from a repository: Tue Nov 15 16:01:04 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins3 (13.04 %)
The number (and %) of the tumor suppressors3 (13.04 %)
Total number of binary PPIs (saturation %)46 (18.18 %)
The number (and %) of affected PPIs23 (50.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.478
Assortativity coefficient-0.3419
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients7 (30.43 %)
The number (and %) of a zero Betweenness Centrality13 (56.52 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: USP16 All fusions
: AI221835;
Proteins found in more fusions USP16 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 USP16parental protein230.078388.667Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zinc_ribbon_9 (PF14369): zinc-ribbon
2 CALM1interactor40.6671.667EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 CDK1oncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
4 CSNK1Dinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
5 DBTinteractor1002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
6 ESR1suppressor60.4005.667Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
7 EXOSC10interactor21.0000DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
8 FBXO11oncoprotein100TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
F-box-like (PF12937, IPR001810): F-box-like
Beta_helix (PF13229): Right handed beta helix region
9 HERC2interactor50.8330.667ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
10 HIST1H2ABinteractor30.6671.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
11 HIST1H2BBinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST1H2BLinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST2H2AA3interactor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
14 HIST2H2ACinteractor40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
15 HIST4H4interactor100CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
16 IGF2BP3interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
17 PLK1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
18 PTOV1interactor21.0000Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
19 RNF8suppressor50.8330.667FHA (PF00498, IPR000253, SM00240): FHA domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
20 TXNL1interactor21.0000PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
21 UBCprotein found in more fusions100.30624.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
22 UBDinteractor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
23 XPO1interactor30.6671.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CALM1interactorEF-hand_7 (PF13499, IPR011992): EF-hand domain pairAI221835
2 CDK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domainAI221835
3 CSNK1DinteractorPkinase (PF00069, IPR000719): Protein kinase domainAI221835
4 DBTinteractor2-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
AI221835
5 ESR1suppressorOest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
AI221835
6 FBXO11oncoproteinTFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
F-box-like (PF12937, IPR001810): F-box-like
Beta_helix (PF13229): Right handed beta helix region
AI221835
7 HIST1H2BBinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4AI221835
8 HIST1H2BLinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4AI221835
9 HIST4H4interactorCENP-T_C (PF15511): Centromere kinetochore component CENP-T histone foldAI221835
10 IGF2BP3interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
AI221835
11 PLK1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
AI221835
12 PTOV1interactorMed25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2AI221835
13 RNF8suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
AI221835
14 TXNL1interactorPITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
AI221835
15 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin familyAI221835
16 UBDinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin familyAI221835
17 USP16parental proteinCwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zinc_ribbon_9 (PF14369): zinc-ribbon
AI221835

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