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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins USP1 (from a repository: Tue Nov 15 11:37:51 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins11 (21.15 %)
The number (and %) of the tumor suppressors9 (17.31 %)
Total number of binary PPIs (saturation %)117 (8.82 %)
The number (and %) of affected PPIs52 (44.44 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.038
Assortativity coefficient-0.3819
The network average Clustering coefficient0.443
The number (and %) of a zero Clustering coefficients18 (34.62 %)
The number (and %) of a zero Betweenness Centrality28 (53.85 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: USP1 All fusions
: BG291031;
Proteins found in more fusions HSPB1 (see 3 fusions); VPS26A (see 1 fusions); TRAF6 (see 1 fusions); USP1 (see 1 fusions); PCNA (see 1 fusions); TP53 (see 3 fusions); UBC (see 1 fusions); JUP/MYH9 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 USP1parental protein520.0422298.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
2 ALDH16A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ANAPC1suppressor30.6670.500PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
4 ANXA2P2interactor100NA
5 ATAD5interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
AAA_16 (PF13191): AAA ATPase domain
6 BAG6interactor60.4006.000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
7 CALML3interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
8 CALML5interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9 CAPNS1interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CERKinteractor21.0000DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
11 CSE1Loncoprotein50.5004.500CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
12 DSC1interactor40.8330.667Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
13 DSG1interactor40.8330.667Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
14 DTX3oncoprotein100zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 FANCD2oncoprotein60.3338.500FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
16 FLGinteractor100Filaggrin (PF03516, IPR003303): Filaggrin
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
Hid1 (PF12722): High-temperature-induced dauer-formation protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
17 FZR1suppressor40.5001.833WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 HSPB1oncoprotein41.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 ID2oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
20 JUPsuppressor50.5005.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
21 KATNA1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
22 KPNA1interactor30.6671.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
23 KRT17interactor100DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798)
Filament (PF00038, IPR001664): Intermediate filament protein
24 KRT4interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
25 LGALS7suppressor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
26 LYZinteractor21.0000Lys (PF00062, IPR001916, SM00263): C-type lysozyme/alpha-lactalbumin family
27 MYH9suppressor50.4005.667IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
28 PCNAoncoprotein80.4298.667PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
29 PHF7interactor100zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
30 PHLPP1suppressor31.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
31 PHLPP2suppressor31.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
32 PKP1interactor31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
33 RAD51AP1interactor30.6671.000RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
34 RSRP1oncoprotein100RSRP (PF17069): Arginine/Serine-Rich protein 1
35 SGTBinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
36 SOCS6interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
37 SORT1interactor21.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
38 SYNCRIPinteractor30.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
39 TAGLN2interactor100Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
40 TOR1AIP1interactor100LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
41 TP53suppressor110.33325.833DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
42 TRAF6protein found in more fusions50.8330.667SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
43 TRIM46interactor100FlgN (PF05130, IPR007809): FlgN protein
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
44 UBCprotein found in more fusions130.25842.833ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
45 UBE2Ainteractor60.6002.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 UNC45Ainteractor40.6671.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
47 USP4oncoprotein50.6671.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
48 USP43interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
49 VPS26Aprotein found in more fusions40.6671.000Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
50 VPS36interactor40.6671.000EAP30 (PF04157, IPR007286): EAP30/Vps36 family
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
51 WDR48suppressor80.39316.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
52 WDR5interactor60.5335.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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