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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins USF2 (from a repository: Sat Dec 3 23:16:08 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins10 (43.48 %)
The number (and %) of the tumor suppressors4 (17.39 %)
Total number of binary PPIs (saturation %)56 (22.13 %)
The number (and %) of affected PPIs23 (41.07 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.913
Assortativity coefficient-0.3419
The network average Clustering coefficient0.567
The number (and %) of a zero Clustering coefficients6 (26.09 %)
The number (and %) of a zero Betweenness Centrality13 (56.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: USF2 All fusions
: S50537;
Proteins found in more fusions S100A8 (see 3 fusions); FOS (see 4 fusions); EP300 (see 1 fusions); SERPINB4/SERPINB3 (see 1 fusions); USF2 (see 1 fusions); USF1 (see 3 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 USF2parental protein230.100383.333DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
2 ADAMTS12interactor21.0000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 BIRC5interactor200BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
4 BRCA1suppressor60.7003.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 EP300oncoprotein90.53610.000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
6 FOSoncoprotein60.7001.833bZIP_1 (PF00170, IPR004827): bZIP transcription factor
7 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
8 FUSsuppressor31.0000Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
9 HSPA4Linteractor100HSP70 (PF00012, IPR013126): Hsp70 protein
10 LZTS2suppressor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
11 MAFoncoprotein41.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
12 NPM1suppressor60.8001.333Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
13 PPARGC1Ainteractor40.8330.500Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
14 PSG1interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
15 PTP4A2interactor100Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
16 RELAoncoprotein80.5716.500DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
17 S100A8oncoprotein40.6671.000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 S100A9oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
19 SERPINB3oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
20 SERPINB4oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
21 TEAD2interactor100TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
22 TFAP4oncoprotein30.6671.000DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
23 USF1oncoprotein70.4677.500HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion

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