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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UROD (from a repository: Sat Nov 12 09:33:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins6 (35.29 %)
The number (and %) of the tumor suppressors3 (17.65 %)
Total number of binary PPIs (saturation %)32 (23.53 %)
The number (and %) of affected PPIs17 (53.12 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.824
Assortativity coefficient-0.4219
The network average Clustering coefficient0.484
The number (and %) of a zero Clustering coefficients6 (35.29 %)
The number (and %) of a zero Betweenness Centrality11 (64.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UROD All fusions
: AA368910;
Proteins found in more fusions CHD3 (see 1 fusions); EGFR (see 2 fusions); UROD (see 1 fusions); FAF1 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 URODparental protein170.067218.333URO-D (PF01208, IPR000257): Uroporphyrinogen decarboxylase (URO-D)
2 BAG3oncoprotein40.6670.667BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
3 CHD3oncoprotein50.5002.667CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
4 CHRAC1interactor30.6671.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
5 EGFRoncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 FAF1protein found in more fusions200UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
7 FAM84Binteractor100LRAT (PF04970, IPR007053): Lecithin retinol acyltransferase
8 HMGXB4oncoprotein100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4171 (PF13775, IPR025228): Domain of unknown function (DUF4171)
RMP (PF14996, IPR029239): Retinal Maintenance
9 MOV10interactor21.0000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
10 MTAPsuppressor21.0000PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
11 MYCBPinteractor21.0000Pox_TAA1 (PF03295, IPR004975): Poxvirus trans-activator protein A1 C-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
12 NME1suppressor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
13 NXF1interactor40.6670.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
14 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
15 TIPRLinteractor100TIP41 (PF04176, IPR007303): TIP41-like family
16 VIMsuppressor40.6670.667Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
17 WDR45Binteractor100ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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