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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins8 (25.00 %)
The number (and %) of the tumor suppressors3 (9.38 %)
Total number of binary PPIs (saturation %)172 (34.68 %)
The number (and %) of affected PPIs32 (18.60 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI9.812
Assortativity coefficient-0.3598
The network average Clustering coefficient0.625
The number (and %) of a zero Clustering coefficients2 (6.25 %)
The number (and %) of a zero Betweenness Centrality5 (15.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: URI1 All fusions
: DL057210; AA828807;
Proteins found in more fusions URI1 (see 2 fusions); APP (see 4 fusions); POLR2E (see 2 fusions); HSP90AA1 (see 2 fusions); OFD1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 URI1parental protein320.271364.941CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Prefoldin (PF02996, IPR004127): Prefoldin subunit
DUF3835 (PF12927, IPR024325): Domain of unknown function (DUF3835)
SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum
2 APPprotein found in more fusions100.44413.008APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ATF7interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
4 BLMsuppressor31.0000BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
5 DMAP1interactor31.0000DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1)
SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
6 GPN1interactor80.7861.640ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein
NB-ARC (PF00931, IPR002182): NB-ARC domain
7 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
8 HSP90AA1oncoprotein100.52811.434HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
9 ITCHinteractor50.8330.182C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
10 KRASoncoprotein40.6670.333Ras (PF00071, IPR001806, SM00173): Ras family
11 NEDD4suppressor70.6002.615Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
12 NPHP1interactor70.8670.364SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
13 OFD1protein found in more fusions90.8211.031APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
14 PDRG1interactor160.45832.898Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
15 PIH1D1interactor200.51636.708PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
16 POLR1Ainteractor100.6009.303RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
17 POLR2Eprotein found in more fusions180.47829.381RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
18 POLR3Einteractor100.8002.474Sin_N (PF04801, IPR006886): Sin-like protein conserved region
DUF2382 (PF09557, IPR019060): Domain of unknown function (DUF2382)
19 PPP1CAsuppressor140.6929.527Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
20 PPP1CBinteractor60.9330.333Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
21 PPP1CConcoprotein100.7335.032Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
22 PPP1R3Ainteractor80.8571.415CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
23 RPAP2interactor140.57116.075NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
24 RPAP3interactor220.45554.708TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
25 RPS6KB1interactor60.6001.833Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
26 RUVBL1oncoprotein150.57118.260TIP49 (PF06068, IPR010339): TIP49 C-terminus
27 RUVBL2oncoprotein170.55824.245TIP49 (PF06068, IPR010339): TIP49 C-terminus
28 SCP2interactor40.6670.432SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
29 SKAP1interactor60.6001.265PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 TTI1interactor61.0000Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
VHS (PF00790, IPR002014, SM00288): VHS domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
31 UXTinteractor140.52721.204Prefoldin (PF02996, IPR004127): Prefoldin subunit
32 XPO1interactor120.57617.356CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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