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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ULK1 (from a repository: Tue Nov 15 17:30:50 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins13 (28.26 %)
The number (and %) of the tumor suppressors9 (19.57 %)
Total number of binary PPIs (saturation %)185 (17.87 %)
The number (and %) of affected PPIs46 (24.86 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI7.261
Assortativity coefficient-0.2608
The network average Clustering coefficient0.607
The number (and %) of a zero Clustering coefficients4 (8.70 %)
The number (and %) of a zero Betweenness Centrality14 (30.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ULK1 All fusions
: BG820543; BF886750;
Proteins found in more fusions GABARAP (see 2 fusions); TRAF6 (see 1 fusions); SQSTM1 (see 5 fusions); CDC37 (see 2 fusions); G3BP1 (see 1 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); ULK1 (see 2 fusions); USP10 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ULK1parental protein460.1231367.470Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
2 AMBRA1interactor90.41716.452Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 ATG101interactor60.6004.056ATG101 (PF07855, IPR012445): Autophagy-related protein 101
4 ATG13oncoprotein130.42325.858ATG13 (PF10033, IPR018731): Autophagy-related protein 13
5 ATG16L1interactor80.5246.205ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
6 ATG4Binteractor80.7143.222Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
7 BECN1suppressor90.35715.452APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
8 CDC37protein found in more fusions60.6003.000CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
9 DAPK3suppressor200OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase (PF00069, IPR000719): Protein kinase domain
PspA_IM30 (PF04012, IPR007157): PspA/IM30 family
10 EXOC2interactor40.8330.667PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
TIG (PF01833, IPR002909): IPT/TIG domain
Sec5 (PF15469): Exocyst complex component Sec5
11 EXOC8interactor40.8330.667K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
12 FLCNsuppressor40.6671.667Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
Folliculin_C (PF16692, IPR032035): Folliculin C-terminal domain
13 G3BP1protein found in more fusions51.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
14 GABARAPsuppressor160.43835.364Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
15 GABARAPL1interactor100.6445.751Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
16 GABARAPL2interactor100.7114.098Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
17 HTTprotein found in more fusions50.8330.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
18 IRF3suppressor40.6670.500IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
19 IRGMinteractor50.6671.333IIGP (PF05049, IPR007743): Interferon-inducible GTPase (IIGP)
20 MAP1LC3Ainteractor100.48912.129Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
21 MAP1LC3Binteractor100.57810.479Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
22 MAP1LC3Cinteractor90.6395.207Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
23 MBPinteractor21.0000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
24 MEFVinteractor90.41713.6897TMR-HDED (PF07697, IPR011624): 7TM-HD extracellular
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
25 MLST8interactor41.0000Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
26 MTORoncoprotein100.52811.000DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
27 MUL1interactor41.0000DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
28 NLRP3oncoprotein21.0000NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
29 OCLNinteractor100MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
30 PPP1CAsuppressor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
31 PRKAA1suppressor100.46719.000Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
32 PRKAA2suppressor100.44419.833Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
33 PRKAB1oncoprotein51.0000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
34 PRKAB2interactor70.8002.000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
35 PRKAG1interactor51.0000CBS (PF00571, IPR000644, SM00116): CBS domain
36 RAB1Aoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
37 RALBoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
38 RB1CC1suppressor100.44419.150Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
39 RPTORprotein found in more fusions100.50012.500HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
40 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
41 SESN2interactor40.6670.650PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
42 SQSTM1oncoprotein180.32476.777PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
43 SYNGAP1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF2647 (PF10839, IPR022546): Protein of unknown function (DUF2647)
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
44 TRAF6protein found in more fusions110.35625.167SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
45 TRIM21interactor110.53313.825DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
46 USP10protein found in more fusions60.7002.167PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
YukD (PF08817, IPR024962): WXG100 protein secretion system (Wss), protein YukD

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