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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UGP2 (from a repository: Sat Nov 12 09:37:14 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins20 (38.46 %)
The number (and %) of the tumor suppressors7 (13.46 %)
Total number of binary PPIs (saturation %)215 (16.21 %)
The number (and %) of affected PPIs52 (24.19 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI7.462
Assortativity coefficient-0.3318
The network average Clustering coefficient0.587
The number (and %) of a zero Clustering coefficients8 (15.38 %)
The number (and %) of a zero Betweenness Centrality17 (32.69 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UGP2 All fusions
Proteins found in more fusions UGP2 (see 1 fusions); HDAC7 (see 1 fusions); ILK (see 1 fusions); PLOD2 (see 1 fusions); CUL1 (see 3 fusions); ARIH2 (see 2 fusions); PUF60 (see 2 fusions); PACSIN2 (see 1 fusions); LYN (see 1 fusions); FAF1 (see 2 fusions); MCM2 (see 1 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UGP2parental protein520.1121696.221UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
2 ABCA1oncoprotein100ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
3 ALDH16A1interactor21.0000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 ARIH2protein found in more fusions31.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 BUB1Boncoprotein31.0000Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
6 CARM1oncoprotein70.7622.567K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain
CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
7 CBSprotein found in more fusions60.7002.067CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
8 CC2D1Binteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
SlyX (PF04102, IPR007236): SlyX
Snf7 (PF03357, IPR005024): Snf7
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
9 CDK2suppressor130.50020.119Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
10 CSDE1oncoprotein60.4675.933CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
SUZ-C (PF12901, IPR024642): SUZ-C motif
S1-like (PF14444, IPR025223): S1-like
11 CUL1suppressor90.5717.233Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 DCAF15interactor100DCAF15_WD40 (PF14939, IPR032734): DDB1-and CUL4-substrate receptor 15, WD repeat
13 DNPEPinteractor50.6671.000Peptidase_M18 (PF02127, IPR001948): Aminopeptidase I zinc metalloprotease (M18)
14 FAF1protein found in more fusions170.48338.302UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
15 FARSBinteractor110.7275.575B3_4 (PF03483, IPR005146, SM00873): B3/4 domain
B5 (PF03484, IPR005147, SM00874): tRNA synthetase B5 domain
16 GARTinteractor120.59113.808AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
Formyl_trans_N (PF00551, IPR002376): Formyl transferase
GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain
GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
17 GCKinteractor100Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
18 GK2interactor100FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain
FGGY_N (PF00370, IPR018484): FGGY family of carbohydrate kinases, N-terminal domain
19 GLRX3interactor31.0000Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Thioredoxin (PF00085, IPR013766): Thioredoxin
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
20 GPSM1interactor41.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_12 (PF13424): Tetratricopeptide repeat
21 HDAC7protein found in more fusions200Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
22 HIRIP3interactor90.7223.279CHZ (PF09649, IPR019098, SM01082): Histone chaperone domain CHZ
23 HSPE1interactor60.5334.400Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
24 HSPH1oncoprotein150.41044.741HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
25 ILKsuppressor80.6673.686Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
26 ISG15suppressor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27 KHKinteractor21.0000PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
28 LYNoncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
29 MCM2oncoprotein130.57615.213AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
30 MROH2Binteractor100BCS1_N (PF08740, IPR014851, SM01024): BCS1 N terminal
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_EZ (PF13513): HEAT-like repeat
31 NTRK1oncoprotein290.230234.265I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 NUDCinteractor60.9330.333CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
33 NUSAP1interactor40.8330.500GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
34 PACSIN2oncoprotein60.7002.667DegS (PF05384, IPR008595): Sensor protein DegS
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
35 PAICSinteractor110.6229.933AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
36 PAPOLAinteractor60.9330.333PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
37 PARVAoncoprotein41.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
38 PCBP1oncoprotein70.7622.633Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
39 PLOD2protein found in more fusions150.37445.0562OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
40 PPM1Ginteractor70.8570.841Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
41 PPP2R5Csuppressor30.6670.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
42 PTPN12suppressor70.5246.533Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTPlike_phytase (PF14566): Inositol hexakisphosphate
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
43 PUF60protein found in more fusions150.44032.708RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
44 RANBP3oncoprotein110.67311.878Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
45 SEToncoprotein140.64112.063NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
46 SNX24interactor100PX (PF00787, IPR001683, SM00312): PX domain
47 TARSinteractor120.50022.586HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
48 TROVE2interactor90.6677.375TROVE (PF05731, IPR008858): TROVE domain
DUF2201 (PF09967, IPR018698): VWA-like domain (DUF2201)
49 UNKinteractor60.4675.500MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
50 USP15oncoprotein50.6670.867UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
51 VASNinteractor50.8001.167EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TraW_N (PF12477, IPR025864): Sex factor F TraW protein N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
52 ZYXsuppressor60.7331.952DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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