Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins UGP2 (from a repository: Sat Nov 12 09:37:14 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 52 The number (and %) of the onco-proteins 20 (38.46 %) The number (and %) of the tumor suppressors 7 (13.46 %) Total number of binary PPIs (saturation %) 215 (16.21 %) The number (and %) of affected PPIs 52 (24.19 %) The number of possible different fusions 13 PPI diameter 2 PPI radius 1 The average degree of PPI 7.462 Assortativity coefficient -0.3318 The network average Clustering coefficient 0.587 The number (and %) of a zero Clustering coefficients 8 (15.38 %) The number (and %) of a zero Betweenness Centrality 17 (32.69 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: UGP2	All fusions
Proteins found in more fusions	UGP2 (see 1 fusions); HDAC7 (see 1 fusions); ILK (see 1 fusions); PLOD2 (see 1 fusions); CUL1 (see 3 fusions); ARIH2 (see 2 fusions); PUF60 (see 2 fusions); PACSIN2 (see 1 fusions); LYN (see 1 fusions); FAF1 (see 2 fusions); MCM2 (see 1 fusions); CBS (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	UGP2	parental protein	52	0.112	1696.221	UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
2	ABCA1	oncoprotein	1	0	0	ABC_tran (PF00005, IPR003439): ABC transporter ABC2_membrane_3 (PF12698): ABC-2 family transporter protein AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
3	ALDH16A1	interactor	2	1.000	0	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4	ARIH2	protein found in more fusions	3	1.000	0	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5	BUB1B	oncoprotein	3	1.000	0	Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2 Pkinase (PF00069, IPR000719): Protein kinase domain XhlA (PF10779, IPR019715): Haemolysin XhlA CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
6	CARM1	oncoprotein	7	0.762	2.567	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
7	CBS	protein found in more fusions	6	0.700	2.067	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
8	CC2D1B	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain SlyX (PF04102, IPR007236): SlyX Snf7 (PF03357, IPR005024): Snf7 DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
9	CDK2	suppressor	13	0.500	20.119	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
10	CSDE1	oncoprotein	6	0.467	5.933	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain SUZ-C (PF12901, IPR024642): SUZ-C motif S1-like (PF14444, IPR025223): S1-like
11	CUL1	suppressor	9	0.571	7.233	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12	DCAF15	interactor	1	0	0	DCAF15_WD40 (PF14939, IPR032734): DDB1-and CUL4-substrate receptor 15, WD repeat
13	DNPEP	interactor	5	0.667	1.000	Peptidase_M18 (PF02127, IPR001948): Aminopeptidase I zinc metalloprotease (M18)
14	FAF1	protein found in more fusions	17	0.483	38.302	UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain
15	FARSB	interactor	11	0.727	5.575	B3_4 (PF03483, IPR005146, SM00873): B3/4 domain B5 (PF03484, IPR005147, SM00874): tRNA synthetase B5 domain
16	GART	interactor	12	0.591	13.808	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain Formyl_trans_N (PF00551, IPR002376): Formyl transferase GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
17	GCK	interactor	1	0	0	Hexokinase_1 (PF00349, IPR022672): Hexokinase Hexokinase_2 (PF03727, IPR022673): Hexokinase
18	GK2	interactor	1	0	0	FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain FGGY_N (PF00370, IPR018484): FGGY family of carbohydrate kinases, N-terminal domain
19	GLRX3	interactor	3	1.000	0	Glutaredoxin (PF00462, IPR002109): Glutaredoxin Thioredoxin (PF00085, IPR013766): Thioredoxin TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
20	GPSM1	interactor	4	1.000	0	GoLoco (PF02188, IPR003109, SM00390): GoLoco motif TPR_12 (PF13424): Tetratricopeptide repeat
21	HDAC7	protein found in more fusions	2	0	0	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
22	HIRIP3	interactor	9	0.722	3.279	CHZ (PF09649, IPR019098, SM01082): Histone chaperone domain CHZ
23	HSPE1	interactor	6	0.533	4.400	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
24	HSPH1	oncoprotein	15	0.410	44.741	HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
25	ILK	suppressor	8	0.667	3.686	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
26	ISG15	suppressor	2	1.000	0	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27	KHK	interactor	2	1.000	0	PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
28	LYN	oncoprotein	4	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
29	MCM2	oncoprotein	13	0.576	15.213	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
30	MROH2B	interactor	1	0	0	BCS1_N (PF08740, IPR014851, SM01024): BCS1 N terminal HEAT (PF02985, IPR000357): HEAT repeat HEAT_EZ (PF13513): HEAT-like repeat
31	NTRK1	oncoprotein	29	0.230	234.265	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32	NUDC	interactor	6	0.933	0.333	CS (PF04969, IPR007052): CS domain D5_N (PF08706, IPR014818, SM00885): D5 N terminal like Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc. NuDC (PF16273, IPR032572): Nuclear distribution C domain
33	NUSAP1	interactor	4	0.833	0.500	GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
34	PACSIN2	oncoprotein	6	0.700	2.667	DegS (PF05384, IPR008595): Sensor protein DegS FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
35	PAICS	interactor	11	0.622	9.933	AIRC (PF00731, IPR000031, SM01001): AIR carboxylase SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
36	PAPOLA	interactor	6	0.933	0.333	PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain Macoilin (PF09726, IPR019130): Transmembrane protein
37	PARVA	oncoprotein	4	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
38	PCBP1	oncoprotein	7	0.762	2.633	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
39	PLOD2	protein found in more fusions	15	0.374	45.056	2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
40	PPM1G	interactor	7	0.857	0.841	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PP2C (PF00481, IPR001932): Protein phosphatase 2C DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
41	PPP2R5C	suppressor	3	0.667	0.667	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family) DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
42	PTPN12	suppressor	7	0.524	6.533	Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PTPlike_phytase (PF14566): Inositol hexakisphosphate ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
43	PUF60	protein found in more fusions	15	0.440	32.708	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
44	RANBP3	oncoprotein	11	0.673	11.878	Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
45	SET	oncoprotein	14	0.641	12.063	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
46	SNX24	interactor	1	0	0	PX (PF00787, IPR001683, SM00312): PX domain
47	TARS	interactor	12	0.500	22.586	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
48	TROVE2	interactor	9	0.667	7.375	TROVE (PF05731, IPR008858): TROVE domain DUF2201 (PF09967, IPR018698): VWA-like domain (DUF2201)
49	UNK	interactor	6	0.467	5.500	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
50	USP15	oncoprotein	5	0.667	0.867	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
51	VASN	interactor	5	0.800	1.167	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain TraW_N (PF12477, IPR025864): Sex factor F TraW protein N terminal LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
52	ZYX	suppressor	6	0.733	1.952	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) LIM (PF00412, IPR001781, SM00132): LIM domain DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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