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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)115
The number (and %) of the onco-proteins51 (44.35 %)
The number (and %) of the tumor suppressors6 (5.22 %)
Total number of binary PPIs (saturation %)583 (8.89 %)
The number (and %) of affected PPIs115 (19.73 %)
The number of possible different fusions27
PPI diameter2
PPI radius1
The average degree of PPI9.235
Assortativity coefficient-0.2410
The network average Clustering coefficient0.508
The number (and %) of a zero Clustering coefficients7 (6.09 %)
The number (and %) of a zero Betweenness Centrality18 (15.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBR5 All fusions
: BF154933; BU677222;
Proteins found in more fusions TUBG1 (see 1 fusions); PSMC2 (see 1 fusions); MAGED1 (see 1 fusions); BUB1 (see 1 fusions); CRY2 (see 3 fusions); VCP (see 4 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); DCAF1 (see 1 fusions); PABPC1 (see 2 fusions); CUL3 (see 1 fusions); NCOA1 (see 2 fusions); RANGAP1 (see 2 fusions); RNF168 (see 1 fusions); VHL (see 1 fusions); GTF2E2 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2L3/BIRC2 (see 1 fusions); TOPBP1 (see 2 fusions); UBR5 (see 4 fusions); SRSF1 (see 1 fusions); UBC (see 1 fusions); DDB1 (see 2 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBR5parental protein1150.0659131.992CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
2 ACTR1Ainteractor50.7000.718Actin (PF00022, IPR004000, SM00268): Actin
3 ANKRD28interactor40.6672.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 ARRB2interactor110.45515.125Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ATMINinteractor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 ATP6V1Finteractor60.7331.689ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
7 AURKBinteractor140.39728.608Pkinase (PF00069, IPR000719): Protein kinase domain
8 BARD1oncoprotein140.23139.074BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
9 BIRC2oncoprotein120.50918.555BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 BUB1oncoprotein70.7332.333Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
11 BUB1Boncoprotein90.6435.833Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
12 BUB3interactor90.47213.289WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
13 C1QBPinteractor120.34832.319MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
14 CADoncoprotein160.31751.045Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
MGS (PF02142, IPR011607, SM00851): MGS-like domain
OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
15 CALM1interactor60.6003.619EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
16 CALR3interactor100Calreticulin (PF00262, IPR001580): Calreticulin family
17 CCDC8interactor130.48514.943Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
18 CDC20oncoprotein100.47211.317WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19 CDK9protein found in more fusions100.36119.733Pkinase (PF00069, IPR000719): Protein kinase domain
20 CDKN1Aoncoprotein90.33314.147CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
21 CEBPDsuppressor21.0000bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
22 CEP250interactor100.35614.960ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 CHEK2oncoprotein70.8001.733FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
24 CIB1interactor30.6670.500EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 CRY2protein found in more fusions100.30612.527DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
26 CUL3protein found in more fusions350.164346.662Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27 DCAF1protein found in more fusions150.35237.102DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
28 DDB1protein found in more fusions250.225150.772CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
29 DPPA4interactor60.6002.667Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
30 DSN1interactor31.0000MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
31 DYRK2interactor80.46410.789Pkinase (PF00069, IPR000719): Protein kinase domain
32 EEF1A1oncoprotein180.30956.346GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
33 EIF3Ioncoprotein40.6671.182ISN1 (PF06437, IPR009453): IMP-specific 5'-nucleotidase
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
34 FAF2interactor130.48519.825DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
35 FBXW11interactor120.29127.786WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
36 FOXB1interactor50.4004.500Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
37 FOXG1oncoprotein40.6671.667SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
38 FOXJ2interactor21.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
39 GEMIN5interactor70.3336.084WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
40 GSK3Boncoprotein90.39310.102Pkinase (PF00069, IPR000719): Protein kinase domain
41 GSPT1oncoprotein70.4299.333GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
42 GSPT2interactor31.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
43 GTF2E2protein found in more fusions31.0000TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain
VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
44 GTF2F2interactor40.5003.000TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
45 HDAC11interactor40.5001.082Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
46 IGBP1interactor80.39311.269TAP42 (PF04177, IPR007304): TAP42-like family
47 JAK3interactor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
48 KATNA1interactor50.8000.733AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
49 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
50 KPNA1interactor50.5003.186Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
51 MAGED1protein found in more fusions110.33319.703MAGE (PF01454, IPR002190): MAGE family
52 MAPK1oncoprotein120.40024.752Pkinase (PF00069, IPR000719): Protein kinase domain
53 MAPK3oncoprotein120.38222.819Pkinase (PF00069, IPR000719): Protein kinase domain
54 MCRS1interactor30.6670.667FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
55 MRPL4interactor50.6003.067Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
56 MRPS18Binteractor70.5245.102Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
HTH_21 (PF13276, IPR025948): HTH-like domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
57 MRS2interactor100CcmB (PF03379, IPR003544): CcmB protein
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
58 NCOA1oncoprotein90.46410.367DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
59 NCOA2oncoprotein80.46411.682DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
60 NESinteractor31.0000Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
61 NLRP3interactor100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
62 NR1I2suppressor50.6003.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
63 PABPC1oncoprotein210.247109.314RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
64 PAIP1interactor40.8330.667MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
65 PAIP2suppressor50.7001.833PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
66 PCK1interactor70.5244.967PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
67 PGRsuppressor50.6671.167Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
68 PMS1oncoprotein60.5003.000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
69 PMS2oncoprotein80.50010.002DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
MORN_2 (PF07661, IPR011652): MORN repeat variant
MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
70 POU5F1oncoprotein100.47211.522Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
71 PSMC2protein found in more fusions130.39421.095AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
72 RANGAP1protein found in more fusions90.39311.800RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
73 RECQL5oncoprotein21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5)
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
TAtT (PF16811, IPR031823): TRAP transporter T-component
74 RNF168protein found in more fusions50.8330.400ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
75 SATB1oncoprotein30.6670.667CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
76 SEToncoprotein80.4298.700NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
77 SHFM1interactor50.6001.202CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
78 SIRT6suppressor50.4003.011SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
79 SIRT7interactor190.23493.677DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
80 SMAD2oncoprotein80.6673.682MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
81 SNW1protein found in more fusions250.217148.147SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
82 SOX2oncoprotein100.38917.300HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
83 SPRTNinteractor80.5365.705GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
84 SRSF1protein found in more fusions110.37812.775Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
85 TCEA1oncoprotein30.6671.000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
86 TERToncoprotein90.38917.586RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
87 TNRC6Ainteractor50.7000.952CreD (PF06123, IPR010364): Inner membrane protein CreD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Ago_hook (PF10427, IPR019486): Argonaute hook
M_domain (PF12938, IPR026805): M domain of GW182
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
88 TOB1interactor30.6670.500PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
BTG (PF07742, IPR002087, SM00099): BTG family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
89 TOB2oncoprotein31.0000PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
BTG (PF07742, IPR002087, SM00099): BTG family
90 TOPBP1protein found in more fusions60.6002.400BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
91 TP53oncoprotein360.180369.787DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
92 TPD52L1interactor200TPD52 (PF04201, IPR007327): Tumour protein D52 family
93 TUBG1protein found in more fusions140.41024.815Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
94 TUBGCP3interactor80.39310.867Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
95 TXN2interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
96 UBCprotein found in more fusions360.205337.415ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
97 UBE2Ainteractor80.6673.852UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
98 UBE2Binteractor110.5789.638UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
99 UBE2D1interactor180.30163.633UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
100 UBE2D2oncoprotein110.6007.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
101 UBE2D3interactor80.3818.050UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
102 UBE2L3protein found in more fusions100.6397.538UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
103 UBXN1interactor150.42928.386Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
104 UBXN7interactor150.52422.844UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
105 UQCRC2oncoprotein60.4674.319Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
106 USP49interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
107 UTP15interactor40.6670.404UTP15_C (PF09384, IPR018983): UTP15 C terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
108 VCPprotein found in more fusions230.247119.429AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
109 VHLoncoprotein80.6674.138Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
110 WDR43interactor50.7001.333Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Zip (PF02535, IPR003689): ZIP Zinc transporter
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
111 WDR48suppressor50.7001.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
112 XPNPEP3interactor50.6671.400AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
113 XPO1interactor290.143284.876CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
114 XRCC3oncoprotein40.6672.000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
115 ZNF207interactor21.0000MCPVI (PF02993, IPR004243): Minor capsid protein VI
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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