1 |
UBQLN2 | parental protein | 79 | 0.098 | 3761.922 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family SUZ (PF12752, IPR024771): SUZ domain Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B |
2 |
AARSD1 | interactor | 5 | 0.600 | 3.167 | tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain |
3 |
ADSL | interactor | 8 | 0.821 | 1.852 | DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331) Lyase_1 (PF00206, IPR022761): Lyase ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089) |
4 |
ATXN7 | interactor | 4 | 1.000 | 0 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain Macoilin (PF09726, IPR019130): Transmembrane protein DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505) IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
5 |
BCL2L11 | suppressor | 1 | 0 | 0 | Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain Bim_N (PF06773, IPR014771): Bim protein N-terminus |
6 |
BID | oncoprotein | 3 | 1.000 | 0 | BID (PF06393, IPR010479): BH3 interacting domain (BID) |
7 |
C12orf10 | interactor | 2 | 1.000 | 0 | UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160) |
8 |
C1QA | oncoprotein | 2 | 1.000 | 0 | C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860) |
9 |
CALU | interactor | 10 | 0.422 | 17.488 | EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
10 |
CD93 | interactor | 1 | 0 | 0 | EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Plasmod_Pvs28 (PF06247, IPR010423): Pvs28 EGF domain Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site TMEM154 (PF15102, IPR028064): TMEM154 protein family |
11 |
CUL5 | suppressor | 11 | 0.473 | 17.825 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
12 |
DNAJB1 | suppressor | 10 | 0.444 | 18.638 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
13 |
EDEM1 | interactor | 3 | 0.667 | 0.400 | Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47 |
14 |
EEF1B2 | interactor | 5 | 1.000 | 0 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain |
15 |
ELAVL1 | oncoprotein | 19 | 0.222 | 93.924 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
16 |
EMC3 | interactor | 5 | 0.700 | 3.000 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 |
17 |
EMC7 | interactor | 4 | 1.000 | 0 | DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012) |
18 |
EMC8 | interactor | 4 | 1.000 | 0 | UPF0172 (PF03665, IPR005366): Uncharacterised protein family (UPF0172) |
19 |
EPN1 | interactor | 6 | 0.667 | 3.167 | ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
20 |
EPN2 | interactor | 2 | 1.000 | 0 | ENTH (PF01417, IPR001026, SM00273): ENTH domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
21 |
EPS15 | oncoprotein | 9 | 0.607 | 5.537 | Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
22 |
FAF2 | interactor | 9 | 0.429 | 8.927 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
23 |
FBXO25 | suppressor | 5 | 0.400 | 3.248 | Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A |
24 |
HERC3 | interactor | 5 | 0.700 | 3.000 | RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
25 |
HERC6 | interactor | 3 | 1.000 | 0 | RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
26 |
HERPUD1 | oncoprotein | 5 | 0.800 | 0.686 | Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
27 |
HNRNPA1 | interactor | 11 | 0.644 | 7.021 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
28 |
HNRNPA3 | oncoprotein | 8 | 0.821 | 1.390 | IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
29 |
HNRNPU | interactor | 12 | 0.530 | 14.676 | CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
30 |
HSPA13 | interactor | 3 | 1.000 | 0 | HSP70 (PF00012, IPR013126): Hsp70 protein |
31 |
HTT | protein found in more fusions | 7 | 0.467 | 4.667 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
32 |
IGBP1 | interactor | 8 | 0.357 | 13.133 | TAP42 (PF04177, IPR007304): TAP42-like family |
33 |
INSIG2 | interactor | 5 | 0.600 | 1.933 | INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG) |
34 |
MARCKS | suppressor | 6 | 0.667 | 2.450 | MARCKS (PF02063, IPR002101): MARCKS family |
35 |
MMGT1 | interactor | 5 | 0.700 | 3.000 | MMgT (PF10270, IPR018937): Membrane magnesium transporter |
36 |
NPLOC4 | interactor | 11 | 0.618 | 9.694 | NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4 |
37 |
NTRK1 | oncoprotein | 33 | 0.242 | 255.254 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
38 |
P4HB | interactor | 10 | 0.444 | 13.750 | Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain |
39 |
PDE12 | interactor | 10 | 0.711 | 5.386 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family |
40 |
PFDN2 | interactor | 7 | 0.429 | 9.800 | Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit |
41 |
PLAUR | oncoprotein | 3 | 0.667 | 0.286 | Toxin_1 (PF00087, IPR003571): Snake toxin UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain |
42 |
PRKACA | interactor | 5 | 0.700 | 2.000 | Pkinase (PF00069, IPR000719): Protein kinase domain |
43 |
PRPF40A | protein found in more fusions | 8 | 0.524 | 4.386 | FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
44 |
PSMA2 | interactor | 13 | 0.712 | 8.065 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
45 |
PSMA5 | oncoprotein | 11 | 0.764 | 3.983 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
46 |
PSMA6 | interactor | 12 | 0.727 | 6.954 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
47 |
PSMC1 | interactor | 13 | 0.641 | 14.020 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain |
48 |
PSMC2 | protein found in more fusions | 18 | 0.485 | 44.802 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) |
49 |
RAD23A | oncoprotein | 17 | 0.525 | 27.606 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
50 |
RAD23B | suppressor | 18 | 0.471 | 42.931 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) |
51 |
RNASEH2B | interactor | 3 | 0.667 | 1.000 | RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component) |
52 |
RNF11 | protein found in more fusions | 6 | 0.800 | 1.067 | zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger |
53 |
RNF185 | interactor | 9 | 0.821 | 1.419 | zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
54 |
RNH1 | suppressor | 2 | 1.000 | 0 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
55 |
RPA2 | oncoprotein | 17 | 0.301 | 69.444 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
56 |
SEC23A | interactor | 5 | 0.600 | 2.900 | Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
57 |
SHFM1 | interactor | 12 | 0.697 | 7.289 | CLLAC (PF15675, IPR031379): CLLAC-motif containing domain |
58 |
SNAP23 | protein found in more fusions | 3 | 1.000 | 0 | DivIC (PF04977, IPR007060): Septum formation initiator DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SNAP-25 (PF00835, IPR000928): SNAP-25 family DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089) |
59 |
SSSCA1 | interactor | 10 | 0.556 | 10.586 | Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) |
60 |
STAM | interactor | 8 | 0.464 | 7.752 | GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
61 |
TARDBP | interactor | 10 | 0.639 | 5.702 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
62 |
TP53 | suppressor | 12 | 0.436 | 17.910 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
63 |
TPD52L2 | protein found in more fusions | 9 | 0.429 | 11.186 | TPD52 (PF04201, IPR007327): Tumour protein D52 family |
64 |
TTC1 | interactor | 6 | 0.400 | 7.167 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat |
65 |
UBA2 | interactor | 13 | 0.423 | 30.252 | ThiF (PF00899, IPR000594): ThiF family UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus |
66 |
UBC | protein found in more fusions | 38 | 0.230 | 362.540 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
67 |
UBE2A | interactor | 8 | 0.619 | 3.919 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
68 |
UBE3A | oncoprotein | 13 | 0.545 | 16.602 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A |
69 |
UBL7 | oncoprotein | 9 | 0.583 | 9.919 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
70 |
UBQLN1 | protein found in more fusions | 33 | 0.206 | 305.446 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X |
71 |
UBQLN4 | interactor | 16 | 0.371 | 41.040 | CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain |
72 |
USP34 | interactor | 10 | 0.556 | 10.036 | Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517) |
73 |
USP9X | interactor | 11 | 0.455 | 19.319 | DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain |
74 |
VBP1 | interactor | 5 | 0.400 | 5.400 | Prefoldin (PF02996, IPR004127): Prefoldin subunit |
75 |
WDR4 | interactor | 6 | 0.733 | 1.419 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
76 |
YAP1 | suppressor | 6 | 0.600 | 3.400 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
77 |
ZFYVE19 | interactor | 10 | 0.378 | 20.133 | Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger |
78 |
ZMYM3 | interactor | 2 | 1.000 | 0 | NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR YHS (PF04945, IPR007029): YHS domain zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) SOBP (PF15279, IPR026092): Sine oculis-binding protein |
79 |
ZRANB2 | interactor | 7 | 0.714 | 3.186 | RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3 zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others |