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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UBE3C (from a repository: Sun Dec 4 20:18:45 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins14 (34.15 %)
The number (and %) of the tumor suppressors3 (7.32 %)
Total number of binary PPIs (saturation %)141 (17.20 %)
The number (and %) of affected PPIs41 (29.08 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI6.049
Assortativity coefficient-0.2367
The network average Clustering coefficient0.612
The number (and %) of a zero Clustering coefficients4 (9.76 %)
The number (and %) of a zero Betweenness Centrality11 (26.83 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE3C All fusions
Proteins found in more fusions KDM1A (see 2 fusions); UBE2D2 (see 2 fusions); APP (see 4 fusions); UBC (see 1 fusions); UBE3C (see 1 fusions); PSMC5 (see 2 fusions); MYC (see 1 fusions); TLK1 (see 1 fusions); UTRN (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE3Cparental protein410.1081143.541IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
2 ANXA7suppressor30.6670.667Annexin (PF00191, IPR018502, SM00335): Annexin
3 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 CAND2interactor40.5003.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
5 CCNB1oncoprotein21.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 CPEB4interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
RRM_7 (PF16367, IPR000504): RNA recognition motif
7 ECT2suppressor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
8 EEF2Kinteractor30.6670.667Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
9 EFNB2interactor21.0000Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
10 ELAVL1oncoprotein120.27335.133RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 ESR1suppressor70.6003.233Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
12 FAF2interactor70.4675.356DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
13 GOLGA2interactor40.8330.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
14 KDM1Aprotein found in more fusions80.5716.733Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
15 MTA2interactor50.7001.500BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
16 MYConcoprotein130.40928.433HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
17 NTRK1oncoprotein170.34264.856I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 PANK4interactor30.6670.667DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
19 PHKA2interactor100Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
20 PSMA2interactor100.8062.475Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 PSMC5protein found in more fusions110.6898.141AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
22 PSMD14interactor80.8930.841JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
23 PSMD2oncoprotein110.54514.452PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
24 PSMD6interactor70.9520.286RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
25 RAD21oncoprotein50.8000.556Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
26 RBM15oncoprotein41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SPOC (PF07744, IPR012921): SPOC domain
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
27 SCN2Binteractor21.0000DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
28 SHFM1interactor70.9050.556CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
29 THOC2interactor40.5003.000Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
30 THOC7interactor30.6671.000EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
31 TLK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
32 UBCprotein found in more fusions140.33341.819ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 UBE2D1interactor80.38112.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2D2oncoprotein60.6003.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2D3interactor40.6670.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 UBE2L3interactor70.5334.356UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 USP13interactor40.6672.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
38 UTRNprotein found in more fusions40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
39 VSIG4interactor21.0000EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
40 WDR74interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
41 WDR92interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2

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