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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UBE3A (from a repository: Thu Jul 11 22:22:42 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)161
The number (and %) of the onco-proteins38 (23.60 %)
The number (and %) of the tumor suppressors19 (11.80 %)
Total number of binary PPIs (saturation %)784 (6.09 %)
The number (and %) of affected PPIs161 (20.54 %)
The number of possible different fusions26
PPI diameter2
PPI radius1
The average degree of PPI9.068
Assortativity coefficient-0.3247
The network average Clustering coefficient0.505
The number (and %) of a zero Clustering coefficients25 (15.53 %)
The number (and %) of a zero Betweenness Centrality55 (34.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE3A All fusions
Proteins found in more fusions APP (see 5 fusions); RARA/PML (see 21 fusions); MCM7 (see 2 fusions); UBE3A/YWHAZ (see 1 fusions); CEBPA (see 1 fusions); GFAP (see 3 fusions); HSF1 (see 3 fusions); HSP90AB1 (see 3 fusions); LCK (see 1 fusions); CALR (see 8 fusions); PSAP (see 6 fusions); UBE3A (see 1 fusions); UBQLN1 (see 2 fusions); UBE2D2 (see 1 fusions); UBE2L6 (see 2 fusions); ACTB (see 7 fusions); PRDX1 (see 1 fusions); HIF1AN (see 1 fusions); RARA (see 1 fusions); YWHAZ (see 5 fusions); UBQLN2 (see 3 fusions); UBE2E1 (see 1 fusions); UBC (see 7 fusions); PML (see 4 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE3Aparental protein1610.04519992.687HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
2 ACTA1interactor50.7001.667Actin (PF00022, IPR004000, SM00268): Actin
3 ACTA2interactor60.4674.919Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBoncoprotein120.43618.958Actin (PF00022, IPR004000, SM00268): Actin
5 ACTBL2interactor40.8330.500Actin (PF00022, IPR004000, SM00268): Actin
6 ACTR3interactor80.5369.248Actin (PF00022, IPR004000, SM00268): Actin
7 ADRM1interactor150.8194.721Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
8 AFG3L1Pinteractor21.0000NA
9 AFTPHinteractor21.0000Clathrin_bdg (PF15045, IPR029205): Clathrin-binding box of Aftiphilin, vesicle trafficking
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
10 AHSPinteractor100AHSP (PF09236, IPR015317): Alpha-haemoglobin stabilising protein
11 ANXA1suppressor50.5001.467Annexin (PF00191, IPR018502, SM00335): Annexin
12 ANXA2interactor80.5008.985Annexin (PF00191, IPR018502, SM00335): Annexin
13 APPprotein found in more fusions240.190152.645APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
14 ARoncoprotein140.39725.775Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 ARCinteractor100DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
16 ARHGDIBinteractor21.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
17 ARHGEF15interactor21.0000Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
18 ARNTLsuppressor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
19 ARNTL2interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
20 ARPC1Binteractor110.43622.262WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
21 ASAP3interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
BAR_3 (PF16746): BAR domain of APPL family
22 ASPMoncoprotein31.0000CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
23 ATG9Ainteractor50.5003.833APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
24 BARD1suppressor160.29543.267BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
25 BLKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 BPY2interactor100NA
27 BRCA1suppressor240.265120.684BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
28 BTF3L4interactor41.0000NAC (PF01849, IPR002715): NAC domain
29 C11orf49interactor21.0000NA
30 CALM1interactor160.25851.585EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
31 CALM2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
32 CALRoncoprotein120.38220.429Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
33 CDKN1Bsuppressor70.6194.050CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
34 CEBPAsuppressor90.42912.841Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
35 CEBPZinteractor40.6670.287BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
36 CELA2Binteractor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
37 CFTRsuppressor80.4298.833ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
38 DBNLinteractor80.42911.702RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 DDX39Binteractor60.4673.490DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
40 DLG1suppressor30.6670.667L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
41 DR1interactor100.42219.133CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
42 EAPPinteractor100Serglycin (PF04360, IPR007455): Serglycin
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
43 EID1interactor40.6672.000NA
44 EIF4G1oncoprotein90.38910.516DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
45 ESR1suppressor240.269122.014Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
46 ESR2suppressor80.5715.733zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
47 FAF2interactor140.38531.052DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
48 GFAPprotein found in more fusions50.5002.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
49 GOLGA3interactor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
G-gamma (PF00631, IPR015898, SM00224): GGL domain
SOGA (PF11365, IPR027881): Protein SOGA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
50 GTF3C1interactor40.5000.690B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
51 HBA1interactor21.0000Globin (PF00042, IPR000971): Globin
52 HERC2interactor180.29471.502ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
53 HIF1ANprotein found in more fusions200Cupin_8 (PF13621): Cupin-like domain
54 HPCAL4interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
55 HSF1protein found in more fusions110.40019.372DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
56 HSP90AB1oncoprotein170.41738.273HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
57 HSPA4interactor160.39234.389Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
58 HSPA5oncoprotein190.31462.531HSP70 (PF00012, IPR013126): Hsp70 protein
59 HSPA8oncoprotein210.33376.467HSP70 (PF00012, IPR013126): Hsp70 protein
60 IPO11interactor90.38915.305DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
61 JADE1interactor21.0000C1_2 (PF03107, IPR004146): C1 domain
Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
62 KLHL38interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
63 KRT1interactor50.5004.400Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
64 KRT5interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
65 KRT6Binteractor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
66 KRT7interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
67 KRT9interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
68 LCKoncoprotein50.6671.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
69 LPPoncoprotein80.32111.367LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
70 LRSAM1interactor110.28927.105Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
71 LSM1interactor21.0000LSM (PF01423, IPR001163): LSM domain
72 LSM5interactor100LSM (PF01423, IPR001163): LSM domain
73 MAGEA1interactor30.6671.000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
74 MAGEA8interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
75 MAPK6oncoprotein90.32116.067Pkinase (PF00069, IPR000719): Protein kinase domain
76 MCM7protein found in more fusions90.5366.110MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
77 MDM1interactor100MDM1 (PF15501, IPR029136): Nuclear protein MDM1
78 MDM2oncoprotein280.271156.117Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
79 MEOX2interactor60.4007.133Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
80 METTL1interactor70.5246.400Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
81 MNTsuppressor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Sipho_Gp157 (PF05565, IPR008840): Siphovirus Gp157
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
82 MYCBP2interactor40.8330.286ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHR (PF08005, IPR012983): PHR domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SH3_3 (PF08239, IPR003646): Bacterial SH3 domain
XPA_N (PF01286, IPR022652): XPA protein N-terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
83 MYH9suppressor180.31466.566IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
84 NCOA3oncoprotein120.42424.722DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
85 NDUFA13interactor21.0000GRIM-19 (PF06212, IPR009346): GRIM-19 protein
86 NELFCDoncoprotein60.5333.024TH1 (PF04858, IPR006942): TH1 protein
87 NEURL4interactor50.7001.833Neuralized (PF07177, IPR006573, SM00588): Neuralized
88 NOMO2interactor100DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
DUF4198 (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
SdrD_B (PF17210): SdrD B-like domain
89 NPLOC4interactor120.42426.375NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
90 NTRK1oncoprotein540.118983.162I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
91 P3H1interactor70.4768.952TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
92 PARVAoncoprotein31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
93 PDE1Binteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
PDEase_I_N (PF08499, IPR013706): 3'5'-cyclic nucleotide phosphodiesterase N-terminal
94 PDIA3interactor100.5337.850Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
95 PDIA6interactor60.6672.483FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
96 PGRsuppressor60.9000.286Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
97 PHKA2interactor41.0000Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
98 PHKBinteractor60.6002.422Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
99 PHKG1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
100 PHKG2interactor50.9000.500APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
101 PLAURoncoprotein30.6671.000Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
102 PMLsuppressor80.3818.826zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
103 POLE4interactor200CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
104 PRDX1oncoprotein80.4296.800AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
105 PSAPoncoprotein60.4005.667SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
106 PSMC1interactor220.48164.397AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
107 PSMC3interactor210.51651.151AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
108 PSMD14interactor170.72115.735JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
109 PSMD3interactor140.7918.260Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
110 PSMD4interactor220.53245.795UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
111 PTPN3interactor100FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
112 RAD23Aoncoprotein210.56833.560UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
113 RAD23Bsuppressor170.52928.483K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
114 RARAoncoprotein90.32115.817zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
115 RMI1interactor100RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
RMI1_C (PF16099, IPR032199): Recq-mediated genome instability protein 1, C-terminal OB-fold
116 RNF2interactor250.210152.789zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
117 RPS15Ainteractor80.3939.141Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
118 SACSinteractor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
HEPN (PF05168, IPR007842, SM00748): HEPN domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DUF4368 (PF14287, IPR025378): Domain of unknown function (DUF4368)
ThaI (PF15514, IPR029128): Restriction endonuclease ThaI
119 SCAMP1interactor31.0000SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
120 SCRIBsuppressor21.0000Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SDA1 (PF05285, IPR007949): SDA1
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
121 SENP3interactor70.7141.527Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
122 SF3B3interactor50.6001.502CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
123 SGK223interactor30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Serglycin (PF04360, IPR007455): Serglycin
124 SHBGoncoprotein40.6670.500Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
125 SHFM1interactor190.57331.294CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
126 SOD1interactor80.5713.782Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
127 SPINK1interactor100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
128 SRPRBinteractor40.6671.167MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
129 SRSF9interactor50.5001.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
130 SUMO3interactor60.6003.033Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
131 TALDO1interactor21.0000TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
132 TATsuppressor200Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
TAT_ubiq (PF07706, IPR011715): Aminotransferase ubiquitination site
133 TBC1D14interactor21.0000Sds3 (PF08598, IPR013907): Sds3-like
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
134 TCF19interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
135 TNPO3interactor40.6671.333HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
136 TP53suppressor400.171457.755DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
137 TRIM65interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
138 TRPV5interactor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
139 TSC2suppressor70.6192.853Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
Tuberin (PF03542, IPR018515): Tuberin
DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
140 TTC3interactor31.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
NuiA (PF07924, IPR012489): Nuclease A inhibitor-like protein
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
FlxA (PF14282, IPR025577): FlxA-like protein
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
141 TXNL1interactor150.76211.687PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
142 UBBinteractor60.4672.927ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
143 UBCprotein found in more fusions420.256400.059ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
144 UBE2D1interactor120.45516.429UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
145 UBE2D2oncoprotein140.41026.629UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
146 UBE2D3interactor90.5005.293UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
147 UBE2E1protein found in more fusions80.3339.811UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
148 UBE2L3interactor120.41820.119UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
149 UBE2L6protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
150 UBQLN1protein found in more fusions200.38667.184Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
151 UBQLN2protein found in more fusions130.54517.069Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
152 UBXN1interactor150.35228.829Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
153 UCHL5oncoprotein280.333169.504Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
154 UFD1Linteractor100.51110.802UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
155 UNC45Ainteractor100.37816.656Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
156 USP14interactor150.75214.140UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
157 WDCPinteractor100DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
158 XRCC6oncoprotein170.34249.820Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
159 YOD1interactor51.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
160 YWHAEoncoprotein140.33036.91614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
161 YWHAZprotein found in more fusions160.36239.32414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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