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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UBE2R2 (from a repository: Sun Dec 4 20:18:00 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins15 (46.88 %)
The number (and %) of the tumor suppressors1 (3.12 %)
Total number of binary PPIs (saturation %)91 (18.35 %)
The number (and %) of affected PPIs32 (35.16 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI4.562
Assortativity coefficient-0.3866
The network average Clustering coefficient0.569
The number (and %) of a zero Clustering coefficients7 (21.88 %)
The number (and %) of a zero Betweenness Centrality17 (53.12 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2R2 All fusions
: AA639068;
Proteins found in more fusions UBE2R2 (see 1 fusions); EZR (see 2 fusions); UBE2D2 (see 2 fusions); DTX3L (see 2 fusions); ARIH2 (see 2 fusions); UBA1 (see 2 fusions); YWHAH (see 2 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2R2parental protein320.090758.400NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 APPBP2interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
3 ARHGDIAinteractor31.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4 ARIH2protein found in more fusions41.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 BTRConcoprotein90.50010.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 C9orf78interactor31.0000DHOR (PF06537, IPR010538): Di-haem oxidoreductase, putative peroxidase
Hep_59 (PF07052, IPR010756): Hepatocellular carcinoma-associated antigen 59
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
7 CBLConcoprotein31.0000Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
8 DRG2interactor100MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
9 DTX3Lprotein found in more fusions31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
10 DZIP3interactor31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
11 EZRprotein found in more fusions50.5002.667DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
12 FBXW11interactor70.6004.067WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
13 FBXW5interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
14 GNPDA1interactor40.5002.667Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
15 INF2interactor100Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
16 KRASoncoprotein40.6670.400Ras (PF00071, IPR001806, SM00173): Ras family
17 MEOX1interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
18 NUBP2interactor40.6672.000ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
19 PAK2protein found in more fusions60.8001.333PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
20 PNPLA2interactor100Patatin (PF01734, IPR002641): Patatin-like phospholipase
21 RAD23Aoncoprotein50.6671.667UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
22 RBX1oncoprotein50.8330.500zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
23 RNF113Binteractor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 SFNsuppressor41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
25 UBA1protein found in more fusions80.38110.333ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
26 UBCprotein found in more fusions100.38918.733ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27 UBE2D2oncoprotein100.36120.067UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UBR7interactor31.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
29 WDR4interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
30 YWHAEoncoprotein60.7332.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
31 YWHAGprotein found in more fusions90.53610.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 YWHAHprotein found in more fusions51.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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