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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins17 (34.00 %)
The number (and %) of the tumor suppressors4 (8.00 %)
Total number of binary PPIs (saturation %)134 (10.94 %)
The number (and %) of affected PPIs50 (37.31 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI4.520
Assortativity coefficient-0.2459
The network average Clustering coefficient0.573
The number (and %) of a zero Clustering coefficients10 (20.00 %)
The number (and %) of a zero Betweenness Centrality25 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2O All fusions
: BE928410;
Proteins found in more fusions UBE2O (see 1 fusions); TRAF6 (see 1 fusions); GRK5 (see 4 fusions); RNF11 (see 1 fusions); UBC (see 1 fusions); TRAF4 (see 1 fusions); LUC7L2 (see 2 fusions); LUC7L (see 1 fusions); NAP1L1 (see 3 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2Oparental protein500.0542024.967BUD22 (PF09073, IPR015158): BUD22
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
2 ANKRD1interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
3 APPL1interactor50.8330.400ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
4 BAP1suppressor21.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
5 ECT2suppressor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
6 FRG1interactor21.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
FRG1 (PF06229, IPR010414): FRG1-like domain
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
7 FTSJ3interactor50.4005.067DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
8 GRK5protein found in more fusions40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
9 GSTP1suppressor50.5001.800GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
10 HEXIM1oncoprotein30.6671.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
11 HIST1H2BAinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST1H2BGoncoprotein30.6671.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 ITGB3BPinteractor200CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R
14 KIAA0753interactor31.0000MNR (PF15718, IPR031447): Protein moonraker
15 LCA5interactor50.5004.667IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
16 LUC7Lprotein found in more fusions41.0000LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
17 LUC7L2protein found in more fusions41.0000LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
18 MED4interactor40.6672.000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
19 MGC39584interactor100NA
20 MYConcoprotein50.6672.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
21 NAP1L1protein found in more fusions80.4769.567NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
22 NOL12interactor21.0000DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
23 NTRK1oncoprotein150.23164.500I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
24 NXF1interactor90.25020.167NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 OSMinteractor100LIF_OSM (PF01291, IPR001581, SM00080): LIF / OSM family
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
26 PNKPinteractor21.0000PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
27 POLA2interactor30.6671.000DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
28 POP7interactor21.0000Rpp20 (PF12328, IPR014612): Rpp20 subunit of nuclear RNase MRP and P
29 RAD21oncoprotein60.6673.233Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
30 RNF10interactor21.0000GCS2 (PF04107, IPR006336): Glutamate-cysteine ligase family 2(GCS2)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
31 RNF11protein found in more fusions31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
32 SFRP4suppressor100NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Fz (PF01392, IPR020067, SM00063): Fz domain
33 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
34 SIRT7interactor60.4006.333DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
35 SMAD6interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
36 SMAD7interactor30.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
37 SYT11interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
38 TRAF1oncoprotein60.8001.167HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
39 TRAF2interactor100.44414.667MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
40 TRAF3oncoprotein50.8330.500ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
41 TRAF4oncoprotein41.0000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
42 TRAF5interactor60.6002.833Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
43 TRAF6protein found in more fusions90.5368.567SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
44 TRIM27oncoprotein50.5002.167IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
45 UBCprotein found in more fusions130.28842.733ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 WBSCR22interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
WBS_methylT (PF12589, IPR022238): Methyltransferase involved in Williams-Beuren syndrome
47 WDR26interactor40.6672.000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
48 ZFP41interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
49 ZNF687interactor21.0000PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Fer4_21 (PF14697): 4Fe-4S dicluster domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
50 ZNF707interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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