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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins20 (43.48 %)
The number (and %) of the tumor suppressors7 (15.22 %)
Total number of binary PPIs (saturation %)111 (10.72 %)
The number (and %) of affected PPIs46 (41.44 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI3.435
Assortativity coefficient-0.5154
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients17 (36.96 %)
The number (and %) of a zero Betweenness Centrality30 (65.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2L6 All fusions
: AA480609; AA502470;
Proteins found in more fusions PJA2 (see 1 fusions); RUNX1 (see 1 fusions); ARIH1 (see 4 fusions); RNF216 (see 1 fusions); MAP3K1 (see 1 fusions); TRIM25 (see 2 fusions); SIAH2 (see 1 fusions); RNF40 (see 2 fusions); MCM2 (see 1 fusions); ARIH2 (see 2 fusions); UBE2L6 (see 2 fusions); UBA1 (see 2 fusions); SIAH1 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2L6parental protein460.0341835.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 ARHGDIAinteractor31.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
3 ARIH1protein found in more fusions31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
4 ARIH2protein found in more fusions31.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 BIRC2oncoprotein50.5003.000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 CBLConcoprotein21.0000Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
7 DTX3oncoprotein21.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 FLT3suppressor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
9 HERC5interactor31.0000Peptidase_S51 (PF03575, IPR005320): Peptidase family S51
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
10 ISG15suppressor50.5005.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
11 LONRF1interactor31.0000LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DZR (PF12773, IPR025874): Double zinc ribbon
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
12 MAP3K1oncoprotein40.6670.667zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
13 MCM2oncoprotein70.4008.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
14 MUL1interactor200DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15 PARK2suppressor40.6671.000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16 PJA2protein found in more fusions200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
17 RAD21oncoprotein30.6670.667Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
18 RBCK1interactor50.5002.667GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
19 RBX1oncoprotein31.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
20 RNF122interactor200zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
21 RNF125interactor200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
22 RNF144Asuppressor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
23 RNF144Binteractor100IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 RNF150interactor100PA (PF02225, IPR003137): PA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PspB (PF06667, IPR009554): Phage shock protein B
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
25 RNF19Ainteractor100IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
26 RNF19Binteractor100HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
27 RNF216oncoprotein200DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
28 RNF25interactor31.0000RWD (PF05773, IPR006575, SM00591): RWD domain
Sin_N (PF04801, IPR006886): Sin-like protein conserved region
XK-related (PF09815, IPR018629): XK-related protein
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
29 RNF4interactor200Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
30 RNF40protein found in more fusions200BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
31 RUNX1suppressor40.6671.000Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
32 SIAH1suppressor90.32118.667Sina (PF03145, IPR018121): Seven in absentia protein family
33 SIAH2oncoprotein50.6672.000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
34 SPENoncoprotein21.0000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
35 TIMM8Ainteractor100dDENN (PF03455, IPR005112, SM00801): dDENN domain
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
36 TOPORSsuppressor100Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
37 TRAF7oncoprotein100Sina (PF03145, IPR018121): Seven in absentia protein family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
38 TRIM25protein found in more fusions70.4008.000Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
39 TRIM27oncoprotein60.4006.000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
40 TRIM8interactor50.6671.667dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
41 TYK2interactor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
42 UBA1protein found in more fusions60.5004.667ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
43 UBA6interactor100ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
44 UBA7oncoprotein21.0000ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
45 UBE3Aoncoprotein200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
46 XIAPinteractor80.33314.000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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