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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)233
The number (and %) of the onco-proteins88 (37.77 %)
The number (and %) of the tumor suppressors17 (7.30 %)
Total number of binary PPIs (saturation %)1749 (6.47 %)
The number (and %) of affected PPIs249 (14.24 %)
The number of possible different fusions45
PPI diameter3
PPI radius2
The average degree of PPI13.888
Assortativity coefficient-0.2146
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients20 (8.58 %)
The number (and %) of a zero Betweenness Centrality23 (9.87 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions MAP3K2 (see 2 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); RAC1 (see 1 fusions); UBA1 (see 2 fusions); MYC (see 1 fusions); TNFRSF1A (see 2 fusions); WWP1 (see 1 fusions); RNF216 (see 1 fusions); UBE2D2 (see 2 fusions); AHCYL1 (see 3 fusions); ARIH2 (see 2 fusions); UBE2L3/BIRC2 (see 1 fusions); MDH2 (see 1 fusions); UBE3C (see 1 fusions); SMURF2 (see 1 fusions); AIMP2 (see 1 fusions); AREL1 (see 1 fusions); UBC (see 1 fusions); NEDD4 (see 1 fusions); ARIH1 (see 4 fusions); TRAF6 (see 1 fusions); TNF (see 1 fusions); CASP2 (see 3 fusions); TRIM28 (see 1 fusions); NR3C1 (see 8 fusions); GFAP (see 3 fusions); HUWE1 (see 2 fusions); NCOA1 (see 2 fusions); NEDD4L (see 3 fusions); CD40 (see 2 fusions); ACAT2 (see 1 fusions); UBE2L6 (see 2 fusions); SF1 (see 1 fusions); BAG3 (see 4 fusions); RIPK1 (see 1 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); UBR5 (see 4 fusions); STUB1 (see 1 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); HECW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BIRC2parental protein1200.07313591.026BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 UBE2L3parental protein1300.06216944.922UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 ABHD17Ainteractor21.0000Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Hydrolase_4 (PF12146, IPR022742): Serine aminopeptidase, S33
4 ACAT2protein found in more fusions60.5005.063Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
5 ADRM1interactor80.53628.789Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
6 AHCYL1suppressor210.411102.866AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
7 AICDAinteractor40.33337.066APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
8 AIMP2suppressor110.33333.734GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
9 AREL1protein found in more fusions80.33329.109Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
10 ARIH1protein found in more fusions80.28618.592CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
11 ARIH2protein found in more fusions90.46411.619IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
12 ATXN3interactor140.28258.915Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
13 AURKAoncoprotein210.147221.524Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
14 BAG3oncoprotein170.150175.513BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
15 BCL10oncoprotein130.45519.709CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
16 BIRC3oncoprotein570.1961692.967BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
17 BIRC5interactor120.47335.465BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
18 BIRC7interactor140.41061.507BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 BOLA1interactor200BolA (PF01722, IPR002634): BolA-like protein
20 BRCA1oncoprotein300.155588.505BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
21 CACNA1Ainteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
22 CACNA1Binteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ion_trans (PF00520, IPR005821): Ion transport protein
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
23 CASP10interactor140.65410.729DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
24 CASP2suppressor110.66716.930CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
25 CASP3interactor210.311199.819Peptidase_C14 (PF00656, IPR011600): Caspase domain
26 CASP7interactor120.7455.980Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
27 CASP8oncoprotein220.457165.971DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
28 CASP9oncoprotein120.57624.190CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
29 CBLoncoprotein180.272132.068Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
30 CBLConcoprotein90.55615.608Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
31 CCNB1IP1oncoprotein200MAD (PF05557, IPR008672): Mitotic checkpoint protein
Paramyx_P_V_C (PF03210, IPR004897): Paramyxovirus P/V phosphoprotein C-terminal
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
32 CD27interactor50.7004.103TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
33 CD40protein found in more fusions160.36270.667Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
34 CD40LGinteractor50.9000.167TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
35 CDC42oncoprotein110.31172.243Ras (PF00071, IPR001806, SM00173): Ras family
36 CLEC11Ainteractor40.50015.122ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
37 CSE1Loncoprotein130.20575.921CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
38 CUL9interactor31.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Cullin (PF00888, IPR001373, SM00182): Cullin family
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SDA1 (PF05285, IPR007949): SDA1
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
39 DAZAP1interactor120.30371.179RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
40 DCAF7interactor60.40011.082WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41 DHX9oncoprotein140.41859.013DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
42 DIABLOsuppressor160.36294.074Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
43 DNAJB2interactor70.33342.178DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
44 DNASE2Binteractor31.0000DNase_II (PF03265, IPR004947): Deoxyribonuclease II
45 DTX3oncoprotein80.35716.112zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
46 DZIP3interactor120.30931.702DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
47 E2F1oncoprotein110.364100.331Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
48 EAF2interactor100Paf1 (PF03985, IPR007133): Paf1
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
49 EGFRoncoprotein380.168679.709Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
50 EGLN3suppressor70.46730.1972OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
51 EIF4E2interactor40.5002.774IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
52 ELAVL1oncoprotein500.1041792.480RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
53 ENDOGinteractor30.3333.287Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
54 EXOSC5interactor3046.686RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
55 FBXO2interactor60.6672.281FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
56 FBXO7interactor50.8001.435Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
57 FN1oncoprotein240.149388.851fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
58 FOSoncoprotein60.3006.659bZIP_1 (PF00170, IPR004827): bZIP transcription factor
59 FSD1interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
60 GCC1interactor30.3332.455DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
61 GFAPprotein found in more fusions40.3335.579Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
62 GSK3Boncoprotein210.247169.474Pkinase (PF00069, IPR000719): Protein kinase domain
63 GSPT1oncoprotein40.5001.765GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
64 HACE1suppressor306.970HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
65 HEBP1interactor21.0000SOUL (PF04832, IPR006917): SOUL heme-binding protein
66 HECW1protein found in more fusions100.36136.944C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
67 HECW2interactor80.42910.373C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
68 HERC3interactor60.46717.081RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
69 HERC4interactor60.50014.845RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
70 HERC6interactor40.6670.667RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
71 HSP90B1oncoprotein80.25034.684CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
72 HSPA4interactor280.180436.852Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
73 HSPE1interactor100.24475.203Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
74 HTRA2suppressor160.276132.577Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
75 HUWE1oncoprotein290.206381.495BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
76 IGF2BP1oncoprotein80.32127.078RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
77 IKBKEinteractor130.59119.370IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
78 IKBKGinteractor400.252591.828CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
79 ILF2interactor90.41726.921DZF (PF07528, IPR006561, SM00572): DZF domain
80 ILF3oncoprotein130.29597.808dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
81 ITCHinteractor270.255244.048C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
82 JUPsuppressor100.24446.508Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
83 LIG4interactor30.6670.667APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
84 LTBRoncoprotein100.6679.146Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
85 MAGEA11interactor80.23827.248MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
86 MAP1LC3Binteractor40.33318.092Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
87 MAP3K14interactor170.47555.186Pkinase (PF00069, IPR000719): Protein kinase domain
88 MAP3K2protein found in more fusions110.26742.621PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
89 MAP3K3oncoprotein130.28855.844PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
90 MAPK6oncoprotein80.14366.951Pkinase (PF00069, IPR000719): Protein kinase domain
91 MAVSinteractor180.37593.957Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
92 MCM2oncoprotein230.229290.288AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
93 MDH2protein found in more fusions90.39312.096Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
94 MDM2oncoprotein330.230429.812Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
95 MID1oncoprotein100.33316.391Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
96 MKRN3oncoprotein120.200127.425zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
97 MMACHCinteractor100MMACHC (PF16690, IPR032037): Methylmalonic aciduria and homocystinuria type C family
98 MRPL53interactor50.5004.072MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
99 MSI2oncoprotein40.33315.159NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
100 MUL1interactor110.22246.905DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
101 MXD1oncoprotein203.819HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
102 MYConcoprotein240.182251.239HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
103 NCOA1oncoprotein90.28617.858DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
104 NDFIP1interactor90.33323.542DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
105 NDUFA7interactor40.6671.081CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
106 NEDD4suppressor210.247170.599Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
107 NEDD4Loncoprotein160.200137.058WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
108 NFKB2oncoprotein90.46420.019Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
109 NFKBIAoncoprotein190.257232.929Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
110 NMBinteractor100Bombesin (PF02044, IPR000874): Bombesin-like peptide
111 NOD2interactor120.8363.469CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
112 NR3C1protein found in more fusions150.264164.153GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
113 OTUB1interactor250.270339.450Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
114 PACS2interactor31.0000Pacs-1 (PF10254, IPR019381): PACS-1 cytosolic sorting protein
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
115 PARK2suppressor320.155595.186IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116 PCK2interactor30.33312.214PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
117 PCSK9interactor30.6671.401Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
118 PGAM5interactor80.10726.452His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
119 PIRinteractor80.35735.691Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
120 PITPNAinteractor100IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
121 PJA1interactor110.44427.762zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
122 POLR2Aprotein found in more fusions160.24898.892RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
123 PPM1Kinteractor200PP2C (PF00481, IPR001932): Protein phosphatase 2C
124 PRDX3interactor80.28619.869AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
125 PSMA5oncoprotein130.333109.728Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
126 PSMD2oncoprotein160.22587.818PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
127 PTENoncoprotein150.286178.883DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
128 PTRHD1interactor100PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2
129 RAB10oncoprotein60.5336.283Ras (PF00071, IPR001806, SM00173): Ras family
130 RAC1oncoprotein110.267114.639Ras (PF00071, IPR001806, SM00173): Ras family
131 RAF1oncoprotein150.35263.818Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
132 RBCK1interactor240.368225.880GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
133 RBX1oncoprotein130.25886.943zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
134 RC3H1interactor70.47614.393PaaA_PaaC (PF05138, IPR007814): Phenylacetic acid catabolic protein
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
135 RELAoncoprotein230.333183.570DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
136 RHOAoncoprotein130.30856.765Ras (PF00071, IPR001806, SM00173): Ras family
137 RIPK1protein found in more fusions250.446153.441Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
138 RIPK2interactor160.72412.015CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
139 RIPK3interactor70.9520.272Pkinase (PF00069, IPR000719): Protein kinase domain
TrbM (PF07424, IPR009989): TrbM
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
140 RIPK4interactor50.40016.922Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
141 RNF103interactor50.2006.525VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
142 RNF113Binteractor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
143 RNF125interactor80.28614.391zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
144 RNF144Asuppressor60.20016.971IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
145 RNF144Binteractor40.16711.067IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
146 RNF181interactor80.6196.415AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
147 RNF19Ainteractor30.3334.788IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
148 RNF19Binteractor40.33318.360HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
149 RNF2interactor300.187496.321zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
150 RNF20interactor70.6676.812Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
151 RNF216oncoprotein60.20030.685DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
152 RNF31interactor200.550154.246Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
153 SF1protein found in more fusions100.22249.756UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
154 SH3KBP1protein found in more fusions120.43634.571Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
155 SMAD7interactor130.25640.366MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
156 SMURF1interactor230.255214.350C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
157 SMURF2protein found in more fusions170.308116.042C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
158 SNX12interactor30.6670.445PX (PF00787, IPR001683, SM00312): PX domain
159 SNX3interactor120.28886.079PX (PF00787, IPR001683, SM00312): PX domain
160 SOD1interactor160.30591.932Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
161 SRPRBinteractor110.18275.150MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
162 STUB1suppressor330.244518.049U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
163 SUGP1interactor60.5335.698G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
164 TANKsuppressor120.6917.119DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
165 TAS2R7interactor100TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
166 TIGARinteractor100His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
167 TNFoncoprotein160.46769.751TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
168 TNFAIP3oncoprotein190.59546.677OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
169 TNFRSF12Asuppressor31.0000stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
170 TNFRSF1Aoncoprotein260.363175.006Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
171 TNFSF12suppressor30.6670.167TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
172 TNFSF14interactor50.9000.470TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
173 TOLLIPinteractor130.34882.556C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
174 TP53BP1oncoprotein60.60023.03353-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
175 TRAF1oncoprotein310.359240.871HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
176 TRAF2interactor530.2031231.633MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
177 TRAF3oncoprotein230.364132.207ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
178 TRAF6protein found in more fusions370.311576.348SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
179 TRAF7oncoprotein80.107106.311Sina (PF03145, IPR018121): Seven in absentia protein family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
180 TRIM21interactor140.32182.878DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
181 TRIM28protein found in more fusions170.35074.544ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
182 TRIM32suppressor120.56430.158NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
183 TRIM34interactor307.501SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF2951 (PF11166, IPR021337): Protein of unknown function (DUF2951)
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
184 TRIM39interactor100.38914.050Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
185 TRIP12interactor60.4007.212Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
WWE (PF02825, IPR004170, SM00678): WWE domain
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_2 (PF13646): HEAT repeats
186 TSG101oncoprotein110.244105.412APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
187 TSGA10interactor200Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
188 TSNAXIP1interactor100MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
XH (PF03469, IPR005379): XH domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4600 (PF15372, IPR028022): Domain of unknown function (DUF4600)
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
189 TUFT1interactor201.043USP8_interact (PF08941, IPR015036): USP8 interacting
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
190 UBA1protein found in more fusions210.263213.891ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
191 UBA6interactor120.45537.505ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
192 UBA7oncoprotein203.563ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
193 UBASH3Ainteractor60.8002.718His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
194 UBCprotein found in more fusions960.1344544.598ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
195 UBE2Ainteractor160.37164.550UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
196 UBE2Binteractor170.46780.851UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
197 UBE2D1interactor700.1131902.218UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
198 UBE2D2oncoprotein670.1391705.045UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
199 UBE2D3interactor570.0981102.905UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
200 UBE2J1interactor60.2008.097UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
201 UBE2L6protein found in more fusions230.026446.683UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
202 UBE2Q2interactor50.5001.595Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
203 UBE2Sinteractor120.40031.375ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
204 UBE2V1interactor290.236377.703UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
205 UBE2V2interactor230.277208.495UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
206 UBE2Winteractor190.085154.136UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
207 UBE3Aoncoprotein170.275171.720HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
208 UBE3Cprotein found in more fusions90.4296.465IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
209 UBE4Bsuppressor250.315182.647DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
210 UBOX5interactor90.42912.824U-box (PF04564, IPR003613, SM00504): U-box domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
211 UBR4interactor100.62213.587CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
RecR (PF02132, IPR023628): RecR protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
DZR (PF12773, IPR025874): Double zinc ribbon
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
FAM176 (PF14851): FAM176 family
212 UBR5protein found in more fusions140.42394.093CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
213 UBXN1interactor260.293345.879Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
214 UBXN7interactor200.468117.914UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
215 UCHL3interactor190.33399.560Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
216 UFM1interactor210.324157.300Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
217 USP15oncoprotein190.261185.263UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
218 USP19interactor110.32748.891CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
219 USP26interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
220 USP34interactor120.65218.395Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
221 USP7oncoprotein280.256293.448MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
222 USP9Xinteractor280.328299.208DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
223 VDAC2interactor60.53314.693Porin_3 (PF01459, IPR027246): Eukaryotic porin
224 VPS4Binteractor100.40061.788AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
225 WDR1interactor70.23874.498eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
226 WDR82oncoprotein50.20017.736MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
227 WDYHV1interactor50.5004.983Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
228 WWP1oncoprotein110.53317.185C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
229 WWP2interactor120.32732.718WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
230 XAF1oncoprotein40.8330.154Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
231 XIAPinteractor550.1721813.521BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
232 YAP1oncoprotein160.39260.782Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
233 ZPR1interactor130.52629.977zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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