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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins14 (23.73 %)
The number (and %) of the tumor suppressors4 (6.78 %)
Total number of binary PPIs (saturation %)301 (17.59 %)
The number (and %) of affected PPIs59 (19.60 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI9.186
Assortativity coefficient-0.2142
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients5 (8.47 %)
The number (and %) of a zero Betweenness Centrality15 (25.42 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2C All fusions
: AW404348;
Proteins found in more fusions PSMC2 (see 1 fusions); UBQLN1 (see 2 fusions); RNF216 (see 1 fusions); AHCYL1 (see 3 fusions); BAG3 (see 4 fusions); UBE2C (see 1 fusions); TRIM28 (see 1 fusions); UBC (see 1 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2Cparental protein590.1292191.766UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 AHCYL1suppressor230.36477.348AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
3 ANAPC11interactor60.8001.167zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
4 ANAPC2interactor60.8001.667ANAPC2 (PF08672, IPR014786, SM01013): Anaphase promoting complex (APC) subunit 2
Cullin (PF00888, IPR001373, SM00182): Cullin family
5 ATP6V1B2interactor110.5828.199ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
6 ATP6V1Finteractor110.7273.282ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
7 BAG3oncoprotein70.5336.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 BUB1Boncoprotein70.6674.167Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
9 CDC20oncoprotein80.6674.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10 CKAP2interactor21.0000Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
CKAP2_C (PF15297, IPR029197): Cytoskeleton-associated protein 2 C-terminus
11 CXCR1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF2909 (PF11137, IPR021313): Protein of unknown function (DUF2909)
12 DTX1interactor31.0000WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 ELAVL1oncoprotein70.6004.619RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 ENO2interactor30.6671.000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 FZR1suppressor70.5248.833WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16 KLHL2interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
17 MAD2L1oncoprotein51.0000HORMA (PF02301, IPR003511): HORMA domain
18 MAPK7oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
19 NAXDinteractor30.6670.400Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
20 PCGF3interactor31.0000GAGA (PF09237, IPR015318): GAGA factor
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
21 PCMT1interactor60.3336.272PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
22 POLMinteractor21.0000HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
23 PPM1Ginteractor31.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
24 PSMA5oncoprotein90.6398.017Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
25 PSMB5interactor80.6797.067Proteasome (PF00227, IPR001353): Proteasome subunit
26 PSMC2protein found in more fusions100.7225.267AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
27 PSMC6interactor71.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
28 PSMD4interactor110.61811.850UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
29 RAG1interactor31.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-RAG1 (PF10426, IPR019485): Recombination-activating protein 1 zinc-finger domain
RAG1_imp_bd (PF12560): RAG1 importin binding
RAG1 (PF12940, IPR024627): Recombination-activation protein 1 (RAG1), recombinase
30 RELAoncoprotein70.8001.833DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
31 RNF216oncoprotein200DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
32 SEC24Ainteractor80.5364.498Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
33 SSSCA1interactor190.48428.853Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
34 TAGLN2interactor60.4676.125Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
35 TNNC1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
36 TRIM21interactor31.0000DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
37 TRIM28protein found in more fusions50.6671.400ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
38 TRIP6interactor60.6670.844DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
39 TTC9Cinteractor120.47014.595TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
40 TTLL12interactor130.57715.852TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
41 TYMSinteractor100.5787.374Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
42 UBA1protein found in more fusions70.5335.400ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
43 UBASH3Binteractor50.8330.667His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
44 UBCprotein found in more fusions240.237162.887ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
45 UBE2Binteractor180.52224.991UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 UBE2D3interactor130.25844.786UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
47 UBE2V1interactor130.59011.430UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
48 UBE3Dinteractor200HECT_2 (PF09814, IPR019193): HECT-like Ubiquitin-conjugating enzyme (E2)-binding
49 UBE4Bsuppressor170.51728.494DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
50 UBQLN1protein found in more fusions200.44456.571Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
51 UBQLN4interactor120.6187.117CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
52 UBXN1interactor140.6548.513Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
53 UBXN7interactor160.55816.221UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
54 UNKinteractor160.42528.397MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
55 USP34interactor160.60812.538Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
56 USP9Xinteractor150.63810.737DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
57 YAP1suppressor80.6074.499Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
58 ZFYVE19interactor140.60410.095Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
59 ZRANB2interactor140.58213.866RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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