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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins3 (17.65 %)
The number (and %) of the tumor suppressors3 (17.65 %)
Total number of binary PPIs (saturation %)40 (29.41 %)
The number (and %) of affected PPIs17 (42.50 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI4.118
Assortativity coefficient-0.2875
The network average Clustering coefficient0.585
The number (and %) of a zero Clustering coefficients4 (23.53 %)
The number (and %) of a zero Betweenness Centrality10 (58.82 %)


List of the fusions

PPI for parental proteins: UBAP1 All fusions
Proteins found in more fusions MAP3K1 (see 1 fusions); UBC (see 1 fusions); UBAP1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 UBAP1parental protein170.158170.667MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
2 ACTA2interactor100Actin (PF00022, IPR004000, SM00268): Actin
3 CDC37L1interactor30.6671.000CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
4 ENO1oncoprotein100Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
5 ITGA5suppressor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
6 KIAA1468interactor21.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
HEAT (PF02985, IPR000357): HEAT repeat
Nuc_H_symport (PF03825): Nucleoside H+ symporter
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4128 (PF13554, IPR025395): Bacteriophage related domain of unknown function
HEAT_2 (PF13646): HEAT repeats
7 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
8 MOV10interactor31.0000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
9 NXF1interactor50.8330.500NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
10 PPICinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
11 PTPN23suppressor31.0000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SOGA (PF11365, IPR027881): Protein SOGA
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
12 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
13 TSG101suppressor90.5369.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
14 UBCprotein found in more fusions80.4768.833ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
15 VPS28interactor50.8001.167VPS28 (PF03997, IPR007143): VPS28 protein
16 VPS37Ainteractor41.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
UEV (PF05743, IPR008883): UEV domain
17 XPO1interactor70.47610.167CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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