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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TXNIP (from a repository: Sun Dec 4 21:15:34 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors8 (30.77 %)
Total number of binary PPIs (saturation %)61 (18.77 %)
The number (and %) of affected PPIs26 (42.62 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.769
Assortativity coefficient-0.5950
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients6 (23.08 %)
The number (and %) of a zero Betweenness Centrality16 (61.54 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TXNIP All fusions
: AI949744; BF847181;
Proteins found in more fusions SMURF2 (see 1 fusions); ZBTB16 (see 3 fusions); COPS5 (see 1 fusions); TP53 (see 3 fusions); TXNIP (see 2 fusions); PTPN11 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TXNIPparental protein260.080501.833Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
2 CDKN1Bsuppressor31.0000CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
3 COPS5protein found in more fusions60.7002.333JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
4 DDIT4interactor21.0000RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
5 ECDinteractor21.0000Bradykinin (PF06753, IPR009608): Bradykinin
SGT1 (PF07093, IPR010770): SGT1 protein
6 ELAVL1oncoprotein90.35717.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 FHL1suppressor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
8 HDAC1suppressor50.8330.500FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
9 HDAC3suppressor40.6670.500Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
10 HSPB2interactor40.6671.000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
11 IL12RB1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
12 ITCHinteractor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
13 KDRoncoprotein21.0000Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt)
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
14 NLGN3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
15 PRKAA1suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
16 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
17 RAB5Aoncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
18 RELAoncoprotein50.6671.333DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
19 RGMAinteractor100RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
20 SCELinteractor100FlaF (PF07309, IPR010845): Flagellar protein FlaF
LIM (PF00412, IPR001781, SM00132): LIM domain
IFT43 (PF15305, IPR029302): Intraflagellar transport protein 43
21 SLC2A1interactor21.0000Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
22 SMURF2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
23 TP53suppressor100.36121.833DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
24 TXNoncoprotein31.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
25 ZBTB16suppressor60.5004.333BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
26 ZBTB32interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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