Find Fusion Network

Enter

Fusion ID: Protein names:	TSC22D3 CXCR4
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:

all

affected

independent (normal)

nothing (blank)

Visualization interactions

Cytoscape Web for: parental proteins CXCR4, TSC22D3 (from a repository: Thu Nov 10 14:59:26 2016)

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	56
The number (and %) of the onco-proteins	26 (46.43 %)
The number (and %) of the tumor suppressors	4 (7.14 %)
Total number of binary PPIs (saturation %)	179 (11.62 %)
The number (and %) of affected PPIs	55 (30.73 %)
The number of possible different fusions	17
PPI diameter	5
PPI radius	3
The average degree of PPI	5.286
Assortativity coefficient	-0.3088
The network average Clustering coefficient	0.439
The number (and %) of a zero Clustering coefficients	14 (25.00 %)
The number (and %) of a zero Betweenness Centrality	21 (37.50 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TSC22D3,CXCR4	All fusions : CT004483;
Proteins found in more fusions	JAK2 (see 3 fusions); FOS (see 4 fusions); MYBL2 (see 4 fusions); NEDD4L (see 3 fusions); PTPN11 (see 1 fusions); PTK2 (see 2 fusions); MAD1L1 (see 3 fusions); HLA-B (see 2 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); B2M (see 9 fusions); SGK1 (see 2 fusions); CXCL12 (see 1 fusions); MYOD1 (see 1 fusions); TP53 (see 3 fusions);

List of the fusions

PPI for parental proteins: TSC22D3,CXCR4

All fusions

: CT004483;

Proteins found in more fusions

JAK2 (see 3 fusions); FOS (see 4 fusions); MYBL2 (see 4 fusions); NEDD4L (see 3 fusions); PTPN11 (see 1 fusions); PTK2 (see 2 fusions); MAD1L1 (see 3 fusions); HLA-B (see 2 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); B2M (see 9 fusions); SGK1 (see 2 fusions); CXCL12 (see 1 fusions); MYOD1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	TSC22D3	parental protein	31	0.115	1203.421	TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
2	CXCR4	parental protein	24	0.083	923.817	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
3	ALDH3B1	interactor	1	0	0	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4	ATP13A2	interactor	1	0	0	E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase MARVEL (PF01284, IPR008253): Membrane-associating domain P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
5	B2M	oncoprotein	3	1.000	0	C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
6	C19orf57	interactor	2	0	0	DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
7	CASP8	oncoprotein	4	1.000	0	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
8	CAV1	oncoprotein	6	0.333	12.993	Caveolin (PF01146, IPR001612): Caveolin
9	CCR5	interactor	4	0.667	10.314	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10	CD4	suppressor	3	1.000	0	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
11	CXCL12	suppressor	2	0	0	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
12	CXCR5	interactor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
13	DCLK2	interactor	1	0	0	DCX (PF03607, IPR003533, SM00537): Doublecortin Metallothio_Pro (PF02069, IPR000518): Prokaryotic metallothionein Pkinase (PF00069, IPR000719): Protein kinase domain
14	EID3	interactor	3	1.000	0	Nse4_C (PF08743, IPR014854): Nse4 C-terminal Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
15	ELAVL1	oncoprotein	16	0.143	522.013	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16	ENDOV	interactor	1	0	0	Endonuclease_5 (PF04493, IPR007581): Endonuclease V
17	FIGNL1	interactor	1	0	0	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
18	FOS	oncoprotein	4	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
19	GNA13	interactor	3	0.333	51.993	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
20	GOLT1B	interactor	3	0.333	19.475	Got1 (PF04178, IPR007305): Got1/Sft2-like family
21	GRK3	interactor	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
22	HDAC1	suppressor	12	0.382	41.409	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23	HDAC2	oncoprotein	8	0.619	16.790	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
24	HLA-B	oncoprotein	4	0.333	61.011	MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
25	HPCAL4	interactor	1	0	0	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26	ITCH	interactor	10	0.250	278.507	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27	JAK2	oncoprotein	10	0.389	73.745	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
28	JAK3	oncoprotein	4	0.833	1.321	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
29	JUN	oncoprotein	10	0.500	83.735	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
30	MAD1L1	oncoprotein	5	0.667	2.783	MAD (PF05557, IPR008672): Mitotic checkpoint protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
31	MDM2	oncoprotein	10	0.583	87.404	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32	MTA2	interactor	5	0.900	2.886	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
33	MYBL2	oncoprotein	2	0	0	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
34	MYOD1	oncoprotein	4	1.000	0	Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Mfp-3 (PF04202, IPR007328): Foot protein 3 Myf5 (PF12232, IPR022032): Myogenic determination factor 5
35	NEDD4L	oncoprotein	7	0.667	7.754	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
36	NFKB1	oncoprotein	6	0.400	66.009	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
37	NFKB2	oncoprotein	3	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Death (PF00531, IPR000488, SM00005): Death domain RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38	P4HB	interactor	2	0	0	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
39	PCK1	interactor	3	0.333	82.900	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
40	PLEKHF2	interactor	2	1.000	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PH (PF00169, IPR001849, SM00233): PH domain
41	PTK2	protein found in more fusions	10	0.389	192.965	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
42	PTPN11	oncoprotein	7	0.600	24.875	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
43	PTPN6	oncoprotein	4	0.667	1.333	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
44	RAF1	oncoprotein	7	0.400	100.144	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
45	SCNN1B	oncoprotein	5	0.600	17.132	ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
46	SGK1	oncoprotein	7	0.667	7.754	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
47	SOCS3	suppressor	7	0.476	116.031	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
48	ST13	oncoprotein	2	0	15.183	Hox9_act (PF04617, IPR006711): Hox9 activation region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
49	STAM	interactor	5	0.500	56.049	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50	SUMO1	interactor	7	0.867	1.427	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
51	TMEM63B	interactor	4	0.167	44.322	RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate Wzy_C (PF04932, IPR007016): O-Antigen ligase DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006) RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
52	TP53	oncoprotein	13	0.409	153.156	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
53	TSC22D4	interactor	1	0	0	AflR (PF08493, IPR013700): Aflatoxin regulatory protein TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
54	UBC	protein found in more fusions	14	0.256	231.312	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55	UBE2I	interactor	8	0.714	5.297	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56	USP14	interactor	2	0	26.740	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

B a c k t o T o p ⇑