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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CXCR4, TSC22D3 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins26 (46.43 %)
The number (and %) of the tumor suppressors4 (7.14 %)
Total number of binary PPIs (saturation %)179 (11.62 %)
The number (and %) of affected PPIs55 (30.73 %)
The number of possible different fusions17
PPI diameter5
PPI radius3
The average degree of PPI5.286
Assortativity coefficient-0.3088
The network average Clustering coefficient0.439
The number (and %) of a zero Clustering coefficients14 (25.00 %)
The number (and %) of a zero Betweenness Centrality21 (37.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TSC22D3,CXCR4 All fusions
: CT004483;
Proteins found in more fusions JAK2 (see 3 fusions); FOS (see 4 fusions); MYBL2 (see 4 fusions); NEDD4L (see 3 fusions); PTPN11 (see 1 fusions); PTK2 (see 2 fusions); MAD1L1 (see 3 fusions); HLA-B (see 2 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); B2M (see 9 fusions); SGK1 (see 2 fusions); CXCL12 (see 1 fusions); MYOD1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TSC22D3parental protein310.1151203.421TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
2 CXCR4parental protein240.083923.8177tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
3 ALDH3B1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 ATP13A2interactor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
5 B2Moncoprotein31.0000C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
6 C19orf57interactor200DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
7 CASP8oncoprotein41.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
8 CAV1oncoprotein60.33312.993Caveolin (PF01146, IPR001612): Caveolin
9 CCR5interactor40.66710.3147tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 CD4suppressor31.0000ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
11 CXCL12suppressor200IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
12 CXCR5interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
13 DCLK2interactor100DCX (PF03607, IPR003533, SM00537): Doublecortin
Metallothio_Pro (PF02069, IPR000518): Prokaryotic metallothionein
Pkinase (PF00069, IPR000719): Protein kinase domain
14 EID3interactor31.0000Nse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
15 ELAVL1oncoprotein160.143522.013RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 ENDOVinteractor100Endonuclease_5 (PF04493, IPR007581): Endonuclease V
17 FIGNL1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
18 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
19 GNA13interactor30.33351.993G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
20 GOLT1Binteractor30.33319.475Got1 (PF04178, IPR007305): Got1/Sft2-like family
21 GRK3interactor100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
22 HDAC1suppressor120.38241.409FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23 HDAC2oncoprotein80.61916.790Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
24 HLA-Boncoprotein40.33361.011MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
25 HPCAL4interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26 ITCHinteractor100.250278.507C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 JAK2oncoprotein100.38973.745FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
28 JAK3oncoprotein40.8331.321Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
29 JUNoncoprotein100.50083.735bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
30 MAD1L1oncoprotein50.6672.783MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
31 MDM2oncoprotein100.58387.404Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32 MTA2interactor50.9002.886BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
33 MYBL2oncoprotein200Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
34 MYOD1oncoprotein41.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
35 NEDD4Loncoprotein70.6677.754WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
36 NFKB1oncoprotein60.40066.009Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
37 NFKB2oncoprotein31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38 P4HBinteractor200Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
39 PCK1interactor30.33382.900PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
40 PLEKHF2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
41 PTK2protein found in more fusions100.389192.965FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
42 PTPN11oncoprotein70.60024.875SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
43 PTPN6oncoprotein40.6671.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
44 RAF1oncoprotein70.400100.144Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
45 SCNN1Boncoprotein50.60017.132ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
46 SGK1oncoprotein70.6677.754Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
47 SOCS3suppressor70.476116.031SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
48 ST13oncoprotein2015.183Hox9_act (PF04617, IPR006711): Hox9 activation region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
49 STAMinteractor50.50056.049GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50 SUMO1interactor70.8671.427Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
51 TMEM63Binteractor40.16744.322RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
52 TP53oncoprotein130.409153.156DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
53 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
54 UBCprotein found in more fusions140.256231.312ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55 UBE2Iinteractor80.7145.297UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56 USP14interactor2026.740UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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