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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TSC22D3 (from a repository: Thu Nov 10 14:59:26 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins16 (51.61 %)
The number (and %) of the tumor suppressors1 (3.23 %)
Total number of binary PPIs (saturation %)101 (21.72 %)
The number (and %) of affected PPIs31 (30.69 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.161
Assortativity coefficient-0.3176
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients7 (22.58 %)
The number (and %) of a zero Betweenness Centrality16 (51.61 %)


List of the fusions

PPI for parental proteins: TSC22D3 All fusions
: AA098994; AA099067;
Proteins found in more fusions FOS (see 4 fusions); NEDD4L (see 3 fusions); MYOD1 (see 1 fusions); MAD1L1 (see 3 fusions); TSC22D3 (see 2 fusions); TP53 (see 3 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TSC22D3parental protein310.115657.033TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
2 ALDH3B1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 C19orf57interactor200DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
4 CASP8oncoprotein41.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
5 DCLK2interactor100DCX (PF03607, IPR003533, SM00537): Doublecortin
Metallothio_Pro (PF02069, IPR000518): Prokaryotic metallothionein
Pkinase (PF00069, IPR000719): Protein kinase domain
6 EID3interactor31.0000Nse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
7 ELAVL1oncoprotein80.47610.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 ENDOVinteractor100Endonuclease_5 (PF04493, IPR007581): Endonuclease V
9 FIGNL1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
10 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
11 HDAC1suppressor120.38228.833FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
12 HDAC2oncoprotein80.6195.667Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
13 HPCAL4interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14 JUNoncoprotein90.5718.533bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
15 MAD1L1oncoprotein50.6671.067MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
16 MDM2oncoprotein80.8101.533Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
17 MTA2interactor50.9000.500BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
18 MYOD1oncoprotein41.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
19 NEDD4Loncoprotein70.6673.167WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20 NFKB1oncoprotein50.6672.000Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
21 NFKB2oncoprotein31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
22 PCK1interactor21.0000PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
23 PLEKHF2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
24 RAF1oncoprotein51.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
25 SCNN1Boncoprotein41.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
26 SGK1oncoprotein70.6673.167Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
27 SUMO1interactor70.8670.733Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
28 TP53oncoprotein110.48917.867DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
29 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
30 UBCprotein found in more fusions110.35625.833ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 UBE2Iinteractor80.7143.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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