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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRPC4 (from a repository: Tue Dec 6 06:09:13 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins2 (18.18 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)38 (69.09 %)
The number (and %) of affected PPIs11 (28.95 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.818
Assortativity coefficient-0.4992
The network average Clustering coefficient0.792
The number (and %) of a zero Clustering coefficients1 (9.09 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRPC4 All fusions
: AF063825; AF063822; AF063824; AF063823;
Proteins found in more fusions HOMER3 (see 1 fusions); TRPC4 (see 4 fusions); TNFRSF1A (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRPC4parental protein110.48927.333Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
IncA (PF04156, IPR007285): IncA protein
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
2 HOMER3protein found in more fusions41.0000COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
3 ITPR1interactor61.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
4 ITPR2interactor100Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
5 ITPR3interactor61.0000DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
6 TNFRSF1Aoncoprotein51.0000Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
7 TRPC1interactor100.6119.333Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
8 TRPC3interactor71.0000Ion_trans (PF00520, IPR005821): Ion transport protein
PBC (PF03792, IPR005542): PBC domain
Tetraspannin (PF00335, IPR018499): Tetraspanin family
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
Ank_3 (PF13606, IPR002110): Ankyrin repeat
MCM_N (PF14551, IPR027925): MCM N-terminal domain
9 TRPC4APinteractor41.0000Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
10 TRPC5interactor90.6119.333Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
11 TRPC6interactor71.0000Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding

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