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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TROAP (from a repository: Sun Nov 13 10:14:47 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins6 (30.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)45 (23.68 %)
The number (and %) of affected PPIs20 (44.44 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.600
Assortativity coefficient-0.4726
The network average Clustering coefficient0.588
The number (and %) of a zero Clustering coefficients4 (20.00 %)
The number (and %) of a zero Betweenness Centrality11 (55.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TROAP All fusions
: AA704972;
Proteins found in more fusions MAPRE1 (see 1 fusions); TROAP (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TROAPparental protein200.099283.000Strep_pep (PF14404, IPR025744): Ribosomally synthesized peptide in Streptomyces species
2 BANPsuppressor31.0000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
3 BYSLinteractor50.6003.667Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
4 CCNJLinteractor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 CLTConcoprotein30.6671.000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
6 DYRK1Aoncoprotein60.4005.667DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
7 DYRK1Boncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
8 ELAVL1oncoprotein40.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 FNTBinteractor21.0000Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
10 KRT31interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
11 KRT40interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
12 KRT8interactor40.8330.667Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 MAPRE1oncoprotein50.5003.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
14 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
15 NINLinteractor100PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
16 SPICE1interactor100SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
17 TRAF2interactor70.3339.667MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
18 TRAF3oncoprotein40.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
19 TRIM23interactor200Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
20 TROinteractor21.0000MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1

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