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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins9 (15.79 %)
The number (and %) of the tumor suppressors3 (5.26 %)
Total number of binary PPIs (saturation %)150 (9.40 %)
The number (and %) of affected PPIs57 (38.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.526
Assortativity coefficient-0.4451
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients17 (29.82 %)
The number (and %) of a zero Betweenness Centrality31 (54.39 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions RABEP1 (see 1 fusions); UBE2D2 (see 2 fusions); AES (see 3 fusions); TRIM26 (see 1 fusions); UBC (see 1 fusions); THAP7 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRIM26parental protein570.0472712.600Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
2 AESprotein found in more fusions40.6670.667TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 ARFGAP3interactor30.6670.500ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
4 CAND1interactor90.32118.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CASKinteractor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
6 CC2D2Ainteractor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
7 CEBPDsuppressor21.0000bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
8 CEP128interactor90.36119.667DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
9 CEP162interactor50.8001.333DivIC (PF04977, IPR007060): Septum formation initiator
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553)
DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
10 CHERPinteractor100CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
G-patch (PF01585, IPR000467, SM00443): G-patch domain
HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
Surp (PF01805, IPR000061, SM00648): Surp module
11 CNTRLoncoprotein41.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
12 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
13 DCLRE1Cinteractor100DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase
DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290)
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
14 DDRGK1interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
15 EMSYinteractor100ENT (PF03735, IPR005491): ENT domain
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
GTA_TIM (PF13547, IPR025195): GTA TIM-barrel-like domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
16 FBF1interactor50.5004.667DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
17 IFI16suppressor30.6671.000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18 IKBKGinteractor70.4676.833CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
19 IRF3suppressor41.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
20 KLC3interactor200TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
21 LCA5interactor31.0000IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
22 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
23 MEPCEinteractor50.6004.000Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
24 METTL8interactor100Methyltransf_28 (PF02636, IPR003788): Putative S-adenosyl-L-methionine-dependent methyltransferase
Methyltransf_25 (PF13649): Methyltransferase domain
25 MNAT1interactor100MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
26 MTCH1interactor100YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
27 ORC1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BAH (PF01426, IPR001025, SM00439): BAH domain
Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
28 OTUB2interactor31.0000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
29 PHF10interactor100Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
MRI (PF15325, IPR028278): Modulator of retrovirus infection
30 PHF7interactor31.0000zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
31 PHF8interactor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
32 PNKPinteractor100PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
33 PYHIN1interactor100HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
34 RABEP1oncoprotein31.0000Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
35 RNF10interactor50.5002.800GCS2 (PF04107, IPR006336): Glutamate-cysteine ligase family 2(GCS2)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
36 RNF126interactor70.6672.800Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
37 RNF2interactor100.36119.300zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
38 SONinteractor50.4005.667Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
G-patch (PF01585, IPR000467, SM00443): G-patch domain
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
RSRP (PF17069): Arginine/Serine-Rich protein 1
39 SOX2oncoprotein41.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
40 SRRM2interactor30.6670.667cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
41 SSX2IPinteractor110.37824.333ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
42 SUMO2interactor40.6671.000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
43 TBK1interactor70.6004.333DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
44 THAP1interactor200THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
45 THAP7protein found in more fusions200THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
46 TOP1oncoprotein30.6670.500DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
47 TRIM41interactor90.32117.500BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
48 UBCprotein found in more fusions130.30341.367ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49 UBE2D1interactor80.6194.633UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
50 UBE2D2oncoprotein80.6194.967UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
51 UBE2D3interactor60.6001.800UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
52 USP36interactor21.0000TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
53 USP39oncoprotein40.6671.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
54 USP5interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
55 XPO1interactor100.26731.400CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
56 ZBTB38interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon
57 ZNF707interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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