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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRAPPC8 (from a repository: Sun Nov 13 01:18:53 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins4 (22.22 %)
The number (and %) of the tumor suppressors1 (5.56 %)
Total number of binary PPIs (saturation %)74 (48.37 %)
The number (and %) of affected PPIs18 (24.32 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI7.111
Assortativity coefficient-0.4045
The network average Clustering coefficient0.703
The number (and %) of a zero Clustering coefficients2 (11.11 %)
The number (and %) of a zero Betweenness Centrality6 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRAPPC8 All fusions
: D82760;
Proteins found in more fusions TRAPPC11 (see 1 fusions); TRAPPC10 (see 3 fusions); TRAPPC8 (see 1 fusions); ACAT2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRAPPC8parental protein180.346120.932TRAPPC-Trs85 (PF12739, IPR024420): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
2 ACAT2protein found in more fusions31.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 BARD1suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
4 NTRK1oncoprotein60.6003.286I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
5 PAXIP1interactor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
6 TECPR1interactor31.0000DUF1768 (PF08719, IPR012816): Domain of unknown function (DUF1768)
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
PH (PF00169, IPR001849, SM00233): PH domain
Hyd_WA (PF06462, IPR006624, SM00706): Propeller
7 TRAPPC10protein found in more fusions90.9290.508Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
TRAPPC10 (PF12584, IPR022233): Trafficking protein particle complex subunit 10, TRAPPC10
8 TRAPPC11protein found in more fusions110.53315.175DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974)
Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
Gryzun-like (PF12742, IPR025876): Gryzun, putative Golgi trafficking
9 TRAPPC12interactor140.57719.932TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
10 TRAPPC13interactor41.0000DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974)
Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Trs65 (PF12735, IPR024662): TRAPP trafficking subunit Trs65
11 TRAPPC2interactor100.8062.210Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
12 TRAPPC2Linteractor110.7115.710Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
13 TRAPPC3interactor80.7862.675TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
14 TRAPPC3Linteractor90.8611.413TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
15 TRAPPC4interactor110.8222.432Sybindin (PF04099, IPR007233): Sybindin-like family
16 TRAPPC6Binteractor80.8930.841TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
17 TRAPPC9interactor80.7862.889PMBR (PF09373, IPR018975): Pseudomurein-binding repeat
TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Vps23_core (PF09454, IPR017916): Vps23 core domain
18 UNKinteractor100MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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