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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins2 (10.53 %)
The number (and %) of the tumor suppressors1 (5.26 %)
Total number of binary PPIs (saturation %)78 (45.61 %)
The number (and %) of affected PPIs19 (24.36 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI7.263
Assortativity coefficient-0.3871
The network average Clustering coefficient0.594
The number (and %) of a zero Clustering coefficients3 (15.79 %)
The number (and %) of a zero Betweenness Centrality5 (26.32 %)


List of the fusions

PPI for parental proteins: TRAPPC10 All fusions
Proteins found in more fusions AMOTL2 (see 1 fusions); TRAPPC10 (see 3 fusions); TRAPPC8 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TRAPPC10parental protein190.333140.574Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
TRAPPC10 (PF12584, IPR022233): Trafficking protein particle complex subunit 10, TRAPPC10
2 AMOTL2protein found in more fusions31.0000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
3 BCL2L14interactor80.5714.417Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
CF222 (PF15661, IPR031362): C6orf222, uncharacterised family
4 CABS1interactor70.5713.267CABS1 (PF15367, IPR026118): Calcium-binding and spermatid-specific protein 1
5 DMTNinteractor100VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
6 GPD2interactor100DAO (PF01266, IPR006076): FAD dependent oxidoreductase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
7 NOTCH1suppressor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
8 RDXinteractor100ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
9 TRAPPC1interactor50.5001.357Sybindin (PF04099, IPR007233): Sybindin-like family
10 TRAPPC12interactor120.6557.817TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
11 TRAPPC2interactor120.6557.140Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
12 TRAPPC2Linteractor110.6895.074Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
13 TRAPPC3Linteractor110.6557.817TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
14 TRAPPC4interactor110.7783.040Sybindin (PF04099, IPR007233): Sybindin-like family
15 TRAPPC5interactor60.6671.357TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
16 TRAPPC6Ainteractor70.9330.200TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
17 TRAPPC6Binteractor90.8062.200TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
18 TRAPPC8protein found in more fusions90.9290.450TRAPPC-Trs85 (PF12739, IPR024420): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
19 TRAPPC9interactor110.54519.290PMBR (PF09373, IPR018975): Pseudomurein-binding repeat
TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Vps23_core (PF09454, IPR017916): Vps23 core domain

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