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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)114
The number (and %) of the onco-proteins34 (29.82 %)
The number (and %) of the tumor suppressors11 (9.65 %)
Total number of binary PPIs (saturation %)697 (10.82 %)
The number (and %) of affected PPIs114 (16.36 %)
The number of possible different fusions29
PPI diameter2
PPI radius1
The average degree of PPI11.386
Assortativity coefficient-0.2571
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients5 (4.39 %)
The number (and %) of a zero Betweenness Centrality18 (15.79 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TPM3 All fusions
: AA075545; DL051249;
Proteins found in more fusions HSPB1/OBSL1 (see 1 fusions); TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); TPM2/MYH9 (see 1 fusions); TPM2/TPM1 (see 1 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); TPM3 (see 2 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); SP1 (see 1 fusions); TPM2 (see 1 fusions); AHCYL1 (see 3 fusions); MAD1L1 (see 3 fusions); PRDX1 (see 1 fusions); EIF4A2 (see 2 fusions); TPM3/TPM2 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); ACTN2 (see 1 fusions); TLK1 (see 1 fusions); HSPB1 (see 3 fusions); THOC1 (see 3 fusions); LRRK2 (see 1 fusions); DAPK1 (see 1 fusions); TPM3/NTRK1 (see 3 fusions); TNNT1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TPM3parental protein1140.0858169.549Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
2 ACTN1protein found in more fusions250.48961.006CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ACTN2protein found in more fusions80.8570.908CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 ACTN4interactor270.44779.878CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 ADD1interactor60.8670.382Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
6 AHCYL1suppressor90.3939.819AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
7 ANLNoncoprotein130.8089.087Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
8 ATP1A1interactor100.40011.935Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 ATP5F1interactor100.42211.552Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
10 BLOC1S6interactor50.5003.000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
11 BRCA1suppressor140.37232.505BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 C1orf216interactor30.6671.000DUF4653 (PF15546, IPR027812): Domain of unknown function (DUF4653)
13 CAP1interactor110.7333.357CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
14 CAPZA2interactor230.49463.485F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
15 CCDC102Binteractor60.7002.000Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
16 CCDC114interactor21.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Histone_HNS (PF00816, IPR001801): H-NS histone family
Hydantoinase_B (PF02538, IPR003692): Hydantoinase B/oxoprolinase
DUF2353 (PF09789, IPR019179): Uncharacterized coiled-coil protein (DUF2353)
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
17 CCDC146interactor30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
18 CCHCR1interactor70.4008.000HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
19 CDC123interactor21.0000D123 (PF07065, IPR009772): D123
20 CDK2suppressor280.362106.563Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
21 CKBinteractor130.48714.777ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
22 CKMT1Ainteractor30.6670.500ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
23 CKMT1Binteractor40.6670.682ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
24 COX4I1interactor60.7332.333COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
25 COX5Ainteractor60.5333.347COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
26 CUL3protein found in more fusions260.190164.629Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27 CUL7protein found in more fusions210.28962.345ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28 CYC1interactor90.38911.733Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
29 DAPK1suppressor70.6002.003ABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
30 DVL2interactor80.5714.716DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
31 EGFRoncoprotein180.41236.891Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32 EIF4A2oncoprotein60.5003.800DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
33 ELAVL1oncoprotein270.222172.663RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 FAM9Cinteractor100Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
35 FASNinteractor150.50517.893Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
36 FBXO5oncoprotein50.4003.233IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
37 FKBP4interactor110.6555.905FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
38 FKBP5interactor90.6117.956FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
39 FN1oncoprotein190.33347.326fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
40 HDAC8interactor50.5001.943DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41 HDDC3interactor100HD_4 (PF13328, IPR003607): HD domain
42 HOOK2interactor40.6670.250HOOK (PF05622, IPR008636): HOOK protein
43 HSF2interactor21.0000HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
44 HSP90AA1oncoprotein300.320137.822HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
45 HSP90AB1oncoprotein300.325128.229HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
46 HSPB1oncoprotein210.33783.712HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
47 IFIT3interactor31.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
48 IKBIPinteractor21.0000Fez1 (PF06818): Fez1
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
49 IQGAP1interactor280.42991.332CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
50 KCNE1interactor100ISK_Channel (PF02060, IPR000369): Slow voltage-gated potassium channel
51 KIFC3oncoprotein50.8330.667Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
52 KXD1interactor21.0000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
53 KYNUinteractor30.6671.000Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
54 LCA5Linteractor100DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
55 LRRK2oncoprotein110.5119.370Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
56 LURAP1interactor21.0000LURAP (PF14854): Leucine rich adaptor protein
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
57 MAD1L1suppressor50.5001.821MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
58 MAGEA11interactor60.4005.400MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
59 MAGED2interactor110.5649.120CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
MAGE (PF01454, IPR002190): MAGE family
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
60 MCCsuppressor21.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
FAM76 (PF16046, IPR032017): FAM76 protein
61 MCM2oncoprotein240.45158.518AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
62 MCM3interactor130.52611.260MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
63 MDC1suppressor90.52810.164FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
64 MGEA5oncoprotein110.50915.309NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
65 MOV10interactor120.25833.545AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
66 MTCH1interactor40.5000.952YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
67 MYH7Binteractor70.7142.650Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
68 MYH9suppressor240.56535.264IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
69 MYO18Ainteractor170.59625.875Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
70 MYO19interactor150.7815.812IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
71 MYO5Cinteractor130.7694.174DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
72 NDUFB10interactor50.7001.083NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
73 NEK2interactor60.4005.500Pkinase (PF00069, IPR000719): Protein kinase domain
74 NTRK1oncoprotein420.217412.206I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
75 NXF1interactor140.32133.244NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
76 OBSL1protein found in more fusions240.31685.707BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
77 OIP5interactor30.6670.500Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
78 OSTF1interactor30.6670.182SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
79 PAN2interactor140.50518.870RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
80 PARK2suppressor130.37921.437IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
81 PAXIP1interactor60.5333.686BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
82 PBX3interactor100Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
PBC (PF03792, IPR005542): PBC domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
83 PDLIM7interactor150.58118.543LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
84 PPP1CBinteractor200.60525.582Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
85 PPP1CConcoprotein130.46225.532Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
86 PRDX1oncoprotein110.4226.326AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
87 PSMA2interactor70.7330.869Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
88 PSMA6interactor120.37920.254Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
89 RAD21oncoprotein100.5339.375Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
90 RNF2interactor120.27323.688zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
91 SEC23IPinteractor30.6671.000DDHD (PF02862, IPR004177, SM01127): DDHD domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
WWE (PF02825, IPR004170, SM00678): WWE domain
92 SEPT9oncoprotein50.4001.597Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
93 SF3A2interactor70.6672.652Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
94 SHMT2interactor90.33311.227SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
95 SP1protein found in more fusions120.6188.655zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
96 STMN1interactor70.4295.004Stathmin (PF00836, IPR000956): Stathmin family
97 SYCE1interactor50.5003.952CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
98 TBCDinteractor40.8330.286HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
99 TFPToncoprotein31.0000GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
100 THAP1interactor41.0000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
101 THOC1protein found in more fusions50.5000.915Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
102 TLK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
103 TNNT1protein found in more fusions40.6670.167Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
104 TP53suppressor280.288148.753DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
105 TP73suppressor51.0000P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
106 TPM1protein found in more fusions400.227396.622Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
107 TPM2protein found in more fusions280.362135.479DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
108 TPM4oncoprotein380.270301.456Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
109 TRAP1oncoprotein120.42415.399HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
110 TRIM27oncoprotein80.42911.333IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
111 TRIP6interactor70.4297.967DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
112 UQCRC2oncoprotein80.5716.003Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
113 VPS52interactor40.6671.000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
114 WASH3Pinteractor21.0000NA

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