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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins17 (26.56 %)
The number (and %) of the tumor suppressors4 (6.25 %)
Total number of binary PPIs (saturation %)313 (15.53 %)
The number (and %) of affected PPIs64 (20.45 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI9.031
Assortativity coefficient-0.1882
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients3 (4.69 %)
The number (and %) of a zero Betweenness Centrality12 (18.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TPD52L2 All fusions
: BF815403;
Proteins found in more fusions AHCYL1 (see 3 fusions); APP (see 4 fusions); VCP (see 4 fusions); EZR (see 2 fusions); TRIM25 (see 2 fusions); UBQLN2 (see 2 fusions); COPS5 (see 1 fusions); PPP2R5E (see 1 fusions); CTH (see 3 fusions); ECHS1 (see 1 fusions); TPD52L2 (see 2 fusions); RANGAP1 (see 2 fusions); CALR (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TPD52L2parental protein640.1162600.490TPD52 (PF04201, IPR007327): Tumour protein D52 family
2 AARSinteractor110.43619.005DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 AARSD1interactor110.56415.397tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACTR2interactor170.54435.877Actin (PF00022, IPR004000, SM00268): Actin
5 ACTR3interactor140.62615.502Actin (PF00022, IPR004000, SM00268): Actin
6 ADORA2Binteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GPR_Gpa2_C (PF11970, IPR022596): G protein-coupled glucose receptor regulating Gpa2 C-term
7 AHCYL1suppressor90.32117.119AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
8 ANP32Asuppressor40.6671.333SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
9 APPprotein found in more fusions130.25839.548APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ARPC1Ainteractor110.7454.699WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 ARPC1Binteractor180.37962.044WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
12 ARPC2interactor170.55127.341P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
13 BTF3L4interactor21.0000NAC (PF01849, IPR002715): NAC domain
14 CALRoncoprotein140.44925.959Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
15 CALUinteractor260.354129.806EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
16 CLNS1Ainteractor40.8330.667Voldacs (PF03517): Regulator of volume decrease after cellular swelling
17 COPS5protein found in more fusions90.4299.886JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18 CTHprotein found in more fusions40.6671.000Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
19 CUL5suppressor90.33315.867Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20 DRAP1interactor31.0000CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
21 ECHS1protein found in more fusions60.6002.952ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
22 EFL1interactor61.0000EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
23 EZRprotein found in more fusions70.4675.967DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
24 GABPB1oncoprotein100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
25 HSD17B10interactor90.36115.719adh_short (PF00106, IPR002198): short chain dehydrogenase
26 IPO11interactor80.7142.660DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
27 MED20interactor30.6670.667Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
28 METTL1interactor100.7114.238Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
29 MOV10interactor90.30617.167AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
30 MRPS2interactor40.5001.567Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
31 MTRinteractor70.5715.305B12-binding (PF02310, IPR006158): B12 binding domain
B12-binding_2 (PF02607, IPR003759, SM01018): B12 binding domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
Met_synt_B12 (PF02965, IPR004223): Vitamin B12 dependent methionine synthase, activation domain
Pterin_bind (PF00809, IPR000489): Pterin binding enzyme
S-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
DUF2760 (PF10816, IPR021212): Domain of unknown function (DUF2760)
32 NIF3L1interactor160.56224.659NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
33 NXF1interactor140.23145.271NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
34 OGTinteractor40.5002.500TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
35 OSGEPinteractor110.7783.800Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
36 P4HBinteractor110.42219.100Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
37 PAFAH1B2oncoprotein21.0000Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
38 PANK4interactor70.9050.733DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
39 PDIA6interactor90.27822.067FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
40 PFDN2interactor50.7002.167Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
41 PPM1Ginteractor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
42 PPP2R5Dinteractor70.8101.001B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
43 PPP2R5Eprotein found in more fusions50.8330.500B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
44 PSMD4interactor50.4004.233UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
45 PTGES3interactor70.6004.233CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
46 RANGAP1protein found in more fusions190.51038.141RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 RPA2oncoprotein120.43925.939RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
48 SAE1interactor100.46717.605ThiF (PF00899, IPR000594): ThiF family
49 SEC31Ainteractor60.3338.352P3A (PF08727, IPR014838): Poliovirus 3A protein like
SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
50 SH3GLB1suppressor160.61016.611BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
51 SSSCA1interactor31.0000Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
52 TARSinteractor21.0000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
53 THG1Linteractor120.7095.502Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
54 TP53RKoncoprotein150.52429.602APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
55 TPD52oncoprotein120.29131.519TPD52 (PF04201, IPR007327): Tumour protein D52 family
56 TPD52L1interactor41.0000TPD52 (PF04201, IPR007327): Tumour protein D52 family
57 TPRKBinteractor160.63315.796CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
58 TRIM25protein found in more fusions60.4005.667Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
59 TXNRD1interactor30.6670.667Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
60 UBQLN2protein found in more fusions90.42912.700Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
61 VAV2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
62 VCPprotein found in more fusions120.30930.689AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
63 WDFY1interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin
64 YWHAQinteractor60.4007.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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