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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins33 (49.25 %)
The number (and %) of the tumor suppressors11 (16.42 %)
Total number of binary PPIs (saturation %)284 (12.84 %)
The number (and %) of affected PPIs67 (23.59 %)
The number of possible different fusions20
PPI diameter2
PPI radius1
The average degree of PPI7.224
Assortativity coefficient-0.2666
The network average Clustering coefficient0.598
The number (and %) of a zero Clustering coefficients6 (8.96 %)
The number (and %) of a zero Betweenness Centrality21 (31.34 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TNK2 All fusions
Proteins found in more fusions NEDD4L (see 3 fusions); MERTK (see 1 fusions); BAG3 (see 4 fusions); KAT8 (see 1 fusions); HSP90AA1 (see 5 fusions); LYN (see 2 fusions); EGFR (see 2 fusions); CTTN (see 1 fusions); KAT5 (see 3 fusions); SIAH2 (see 1 fusions); HECW1 (see 1 fusions); EP300 (see 1 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); SIAH1 (see 4 fusions); ZBTB16 (see 3 fusions); FYN (see 1 fusions); NEDD4 (see 1 fusions); SNX9 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TNK2parental protein670.0823101.495CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
2 AKT1oncoprotein90.6433.752PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ALKoncoprotein60.6672.952MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
4 AMPHoncoprotein40.6671.500BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
5 AQP1interactor50.6672.000MIP (PF00230, IPR000425): Major intrinsic protein
6 ARoncoprotein120.49120.952Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
7 ATG16L1interactor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
8 AXLoncoprotein41.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2627 (PF11118, IPR020138): Protein of unknown function (DUF2627)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
9 BAG3oncoprotein50.6671.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 BCAR1oncoprotein100.37816.767Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
11 BIN1suppressor41.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 CDC42oncoprotein100.30620.238Ras (PF00071, IPR001806, SM00173): Ras family
13 CLTAinteractor70.6673.400Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
14 CLTConcoprotein170.26582.321Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
15 CTTNoncoprotein60.8000.833FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 EEA1interactor200ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Filament (PF00038, IPR001664): Intermediate filament protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
IncA (PF04156, IPR007285): IncA protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
17 EGFRoncoprotein240.281129.571Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
18 EP300oncoprotein110.46715.038Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
19 FABP4interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
20 FYNoncoprotein120.36421.140Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21 GAKoncoprotein60.6673.300DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
22 GALTinteractor100GalP_UDP_tr_C (PF02744, IPR005850): Galactose-1-phosphate uridyl transferase, C-terminal domain
GalP_UDP_transf (PF01087, IPR005849): Galactose-1-phosphate uridyl transferase, N-terminal domain
23 GRB2oncoprotein180.35359.374SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
24 GTSE1interactor70.4769.067GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
25 HCKoncoprotein70.5716.238Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 HECW1protein found in more fusions31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
27 HSH2Dinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
28 HSP90AA1oncoprotein230.260123.971HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
29 KAT5suppressor100.47214.733MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
30 KAT8protein found in more fusions31.0000MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
31 KCNA5interactor51.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
32 KDM3Asuppressor21.0000C1_2 (PF03107, IPR004146): C1 domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
33 KRTAP10-3interactor50.6672.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
34 LTKinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
35 LYNoncoprotein90.6434.702Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
36 MAGI3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
37 MCF2oncoprotein40.6670.400PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
38 MERTKoncoprotein40.6670.667fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
39 NBR1oncoprotein40.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
40 NCK1oncoprotein80.6075.852SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
41 NCK2interactor70.7332.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
42 NEDD4suppressor100.52810.183Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
43 NEDD4Lsuppressor40.6670.667WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
44 NEK6interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
45 NOTCH2NLinteractor40.6672.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
46 NPHP1interactor50.6671.400SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
47 NTRK1oncoprotein180.32469.786I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
48 NTRK2oncoprotein60.5334.250I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
49 NTRK3suppressor40.8330.333I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
50 PDGFRBoncoprotein100.6945.383I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
51 PDK1interactor31.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
52 SH2D1Ainteractor50.6001.650SH2 (PF00017, IPR000980, SM00252): SH2 domain
53 SIAH1suppressor40.6671.000Sina (PF03145, IPR018121): Seven in absentia protein family
54 SIAH2oncoprotein50.6672.000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
55 SMURF1interactor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
56 SNX9protein found in more fusions70.6003.650PX (PF00787, IPR001683, SM00312): PX domain
BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
57 SOCS4interactor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
58 SQSTM1oncoprotein90.28616.083PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
59 SRConcoprotein200.39854.862Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
60 TP53suppressor190.26890.536DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
61 TP73suppressor80.4768.833P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
62 TRIM50interactor21.0000Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Trm112p (PF03966, IPR005651): Trm112p-like protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
63 WASoncoprotein90.5288.617CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
64 WWOXsuppressor31.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
65 WWP2interactor31.0000WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
66 YES1oncoprotein50.8000.500Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
67 ZBTB16suppressor51.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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