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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors6 (40.00 %)
Total number of binary PPIs (saturation %)49 (46.67 %)
The number (and %) of affected PPIs15 (30.61 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.467
Assortativity coefficient-0.4980
The network average Clustering coefficient0.564
The number (and %) of a zero Clustering coefficients5 (33.33 %)
The number (and %) of a zero Betweenness Centrality8 (53.33 %)


List of the fusions

PPI for parental proteins: TNFSF10 All fusions
: BU674610;
Proteins found in more fusions ZDHHC17 (see 2 fusions); RIPK1 (see 1 fusions); TNFSF10 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TNFSF10parental protein150.297115.400NERD (PF08378, IPR011528): Nuclease-related domain
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
2 ACP5interactor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
3 CASP3interactor41.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
4 CASP8suppressor100.7505.400DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
5 CFLARoncoprotein90.7863.667DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
6 FADDsuppressor80.8931.067Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
7 RBM48interactor100DUF2284 (PF10050, IPR019271): Predicted metal-binding protein (DUF2284)
8 RIPK1protein found in more fusions80.9520.333Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
9 SOCS3suppressor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
10 TNFAIP3suppressor71.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
11 TNFRSF10Asuppressor61.0000Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMIE (PF16038, IPR032006): TMIE protein
12 TNFRSF10Bsuppressor80.8931.067Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
13 TNFRSF10Dinteractor100NapE (PF06796, IPR010649): Periplasmic nitrate reductase protein NapE
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
P12 (PF12669): Virus attachment protein p12 family
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
14 TRAF2interactor90.8931.067MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
15 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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