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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)101
The number (and %) of the onco-proteins43 (42.57 %)
The number (and %) of the tumor suppressors23 (22.77 %)
Total number of binary PPIs (saturation %)656 (12.99 %)
The number (and %) of affected PPIs101 (15.40 %)
The number of possible different fusions29
PPI diameter2
PPI radius1
The average degree of PPI11.723
Assortativity coefficient-0.3010
The network average Clustering coefficient0.511
The number (and %) of a zero Clustering coefficients10 (9.90 %)
The number (and %) of a zero Betweenness Centrality16 (15.84 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: TNFRSF1A All fusions
: AU310151; X55313;
Proteins found in more fusions TRAF6 (see 1 fusions); SYK (see 1 fusions); TNF (see 1 fusions); CASP2 (see 3 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); JAK2 (see 3 fusions); PRKCD (see 2 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); TNFRSF1A (see 2 fusions); OPTN (see 1 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); KHDRBS1 (see 1 fusions); EZR (see 2 fusions); RIPK1 (see 1 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); JAK1 (see 1 fusions); PIP4K2B (see 3 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); DAPK1 (see 1 fusions); NOL3 (see 2 fusions); STAT1 (see 1 fusions); TRPC4 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TNFRSF1Aparental protein1010.0996412.783Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
2 ADAM17interactor30.6670.667Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
Reprolysin_5 (PF13688): Metallo-peptidase family M12
ADAM17_MPD (PF16698, IPR032029): Membrane-proximal domain, switch, for ADAM17
3 ARHGDIAinteractor150.7917.702Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4 ATF6interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
5 BAG4interactor30.6670.667BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
6 BCL10suppressor130.59111.971CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
7 BIDoncoprotein150.7918.074BID (PF06393, IPR010479): BH3 interacting domain (BID)
8 BIRC2oncoprotein230.43361.622BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 BIRC3oncoprotein210.50041.354BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 BREoncoprotein40.5002.000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
11 CASP10interactor190.61424.508DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CASP2suppressor130.33329.421CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CASP7interactor90.6435.919Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 CASP8suppressor320.370157.860DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
15 CAV1suppressor140.33036.476Caveolin (PF01146, IPR001612): Caveolin
16 CBLsuppressor140.55116.569Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
17 CHUKsuppressor240.43962.833Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
18 CLIP3interactor50.8000.667Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
19 CRADDinteractor30.6670.400CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Death (PF00531, IPR000488, SM00005): Death domain
20 CSNK1A1Linteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
21 CYLDsuppressor110.6009.776CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
22 DAB2IPsuppressor50.7001.667C2 (PF00168, IPR000008, SM00239): C2 domain
PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
23 DAPK1suppressor50.6671.667ABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
24 DAXXoncoprotein80.6194.133Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
25 EGFRoncoprotein270.274149.546Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26 ELAVL1oncoprotein160.25756.060RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27 EZRprotein found in more fusions160.70514.182DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
28 FADDsuppressor240.43582.595Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
29 FANCD2oncoprotein40.5001.567FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
30 FASsuppressor260.360132.999Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
31 FASLGinteractor170.58834.552PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
32 FYNoncoprotein170.38338.554Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
33 GRB2oncoprotein230.277125.362SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
34 GYS2interactor21.0000Glycogen_syn (PF05693, IPR008631): Glycogen synthase
35 HNRNPDoncoprotein90.32115.500CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
36 HRGsuppressor100Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
37 HSPA8oncoprotein110.36428.419HSP70 (PF00012, IPR013126): Hsp70 protein
38 IKBKBprotein found in more fusions230.42469.523FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
39 IKBKGinteractor310.363143.757CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40 JAK1oncoprotein50.8330.333FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
41 JAK2oncoprotein110.6007.800FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
42 KHDRBS1protein found in more fusions110.48912.755KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
43 LTAoncoprotein30.6671.000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
44 LTBoncoprotein21.0000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
45 MADDsuppressor100DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus
uDENN (PF03456, IPR005113, SM00800): uDENN domain
46 MAGEH1interactor100MAGE (PF01454, IPR002190): MAGE family
47 MAP3K7oncoprotein170.53321.743Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
48 MAPK1oncoprotein60.4004.583Pkinase (PF00069, IPR000719): Protein kinase domain
49 MAPK8oncoprotein190.54944.314DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
50 MSNoncoprotein140.8724.650DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
51 MUC1oncoprotein80.6075.400SEA (PF01390, IPR000082, SM00200): SEA domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
Collectrin (PF16959, IPR031588): Renal amino acid transporter
52 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
53 NOL3oncoprotein70.8001.352CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
54 NSMAFinteractor100Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
55 OPTNprotein found in more fusions80.5714.841ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
56 PHAXinteractor100RNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
57 PIK3CAoncoprotein70.5246.817PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
58 PIK3R1oncoprotein160.50527.995RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
59 PIP4K2Bprotein found in more fusions200PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
60 PPP1CAsuppressor90.36118.352Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
61 PRDX3interactor50.5001.500AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
62 PRKCBsuppressor90.5715.502C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
63 PRKCDsuppressor90.4298.386Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
64 PSMD2oncoprotein60.4007.333PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
65 RHOAsuppressor160.65021.512Ras (PF00071, IPR001806, SM00173): Ras family
66 RIPK1protein found in more fusions330.347165.174Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
67 RIPK2interactor140.7565.035CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
68 RIPK3interactor80.7502.917Pkinase (PF00069, IPR000719): Protein kinase domain
TrbM (PF07424, IPR009989): TrbM
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
69 RNF31interactor140.6928.111Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
70 RNF8suppressor40.6670.200FHA (PF00498, IPR000253, SM00240): FHA domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
71 SGTAinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
72 SH3KBP1protein found in more fusions160.43829.620Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
73 SHARPINinteractor100.8061.590DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
74 SOS1oncoprotein80.7862.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
75 SRConcoprotein210.40053.183Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
76 STAMBPinteractor30.6670.400USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
77 STAT1suppressor110.28921.336SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
78 SUMO1interactor80.5246.090Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
79 SYKsuppressor110.6008.314Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
80 SYNCRIPinteractor60.5335.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
81 TNFoncoprotein240.39180.994TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
82 TNFAIP3suppressor180.64714.844OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
83 TNFRSF10Bsuppressor180.62123.088Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
84 TNFRSF1Boncoprotein160.36254.825TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
85 TNFSF13interactor40.6670.667DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
86 TRADDinteractor220.38166.565Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
87 TRAF1oncoprotein210.56827.526HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
88 TRAF2interactor330.385129.002MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
89 TRAF3oncoprotein180.41239.864ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
90 TRAF6protein found in more fusions260.36799.830SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
91 TRAP1oncoprotein100HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
92 TRPC1interactor80.4768.667Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
93 TRPC4protein found in more fusions51.0000Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
IncA (PF04156, IPR007285): IncA protein
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
94 TRPC4APinteractor100.55616.882Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
95 TRPC5interactor41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
96 UBE2Iinteractor150.31939.180UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
97 UBQLN1protein found in more fusions50.5001.786Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
98 UCHL1suppressor60.5333.309Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
99 USP2interactor90.7501.863UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
100 USP4oncoprotein70.9330.118UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
101 VWA9interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 TNFRSF1Aparental proteinDeath (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
AU310151

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