Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	101
The number (and %) of the onco-proteins	43 (42.57 %)
The number (and %) of the tumor suppressors	23 (22.77 %)
Total number of binary PPIs (saturation %)	656 (12.99 %)
The number (and %) of affected PPIs	101 (15.40 %)
The number of possible different fusions	29
PPI diameter	2
PPI radius	1
The average degree of PPI	11.723
Assortativity coefficient	-0.3010
The network average Clustering coefficient	0.511
The number (and %) of a zero Clustering coefficients	10 (9.90 %)
The number (and %) of a zero Betweenness Centrality	16 (15.84 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TNFRSF1A	All fusions : AU310151; X55313;
Proteins found in more fusions	TRAF6 (see 1 fusions); SYK (see 1 fusions); TNF (see 1 fusions); CASP2 (see 3 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); JAK2 (see 3 fusions); PRKCD (see 2 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); TNFRSF1A (see 2 fusions); OPTN (see 1 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); KHDRBS1 (see 1 fusions); EZR (see 2 fusions); RIPK1 (see 1 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); JAK1 (see 1 fusions); PIP4K2B (see 3 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); DAPK1 (see 1 fusions); NOL3 (see 2 fusions); STAT1 (see 1 fusions); TRPC4 (see 4 fusions);

List of the fusions

PPI for parental proteins: TNFRSF1A

All fusions

: AU310151; X55313;

Proteins found in more fusions

TRAF6 (see 1 fusions); SYK (see 1 fusions); TNF (see 1 fusions); CASP2 (see 3 fusions); MAPK1 (see 1 fusions); CBL (see 1 fusions); JAK2 (see 3 fusions); PRKCD (see 2 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); TNFRSF1A (see 2 fusions); OPTN (see 1 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); KHDRBS1 (see 1 fusions); EZR (see 2 fusions); RIPK1 (see 1 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); JAK1 (see 1 fusions); PIP4K2B (see 3 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); DAPK1 (see 1 fusions); NOL3 (see 2 fusions); STAT1 (see 1 fusions); TRPC4 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	TNFRSF1A	parental protein	101	0.099	6412.783	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
2	ADAM17	interactor	3	0.667	0.667	Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease Disintegrin (PF00200, IPR001762, SM00050): Disintegrin Reprolysin_5 (PF13688): Metallo-peptidase family M12 ADAM17_MPD (PF16698, IPR032029): Membrane-proximal domain, switch, for ADAM17
3	ARHGDIA	interactor	15	0.791	7.702	Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4	ATF6	interactor	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
5	BAG4	interactor	3	0.667	0.667	BAG (PF02179, IPR003103, SM00264): BAG domain DMP12 (PF16779, IPR031891): DNA-mimic protein
6	BCL10	suppressor	13	0.591	11.971	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
7	BID	oncoprotein	15	0.791	8.074	BID (PF06393, IPR010479): BH3 interacting domain (BID)
8	BIRC2	oncoprotein	23	0.433	61.622	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9	BIRC3	oncoprotein	21	0.500	41.354	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10	BRE	oncoprotein	4	0.500	2.000	BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
11	CASP10	interactor	19	0.614	24.508	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
12	CASP2	suppressor	13	0.333	29.421	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
13	CASP7	interactor	9	0.643	5.919	Peptidase_C14 (PF00656, IPR011600): Caspase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
14	CASP8	suppressor	32	0.370	157.860	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
15	CAV1	suppressor	14	0.330	36.476	Caveolin (PF01146, IPR001612): Caveolin
16	CBL	suppressor	14	0.551	16.569	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
17	CHUK	suppressor	24	0.439	62.833	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
18	CLIP3	interactor	5	0.800	0.667	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
19	CRADD	interactor	3	0.667	0.400	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Death (PF00531, IPR000488, SM00005): Death domain
20	CSNK1A1L	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
21	CYLD	suppressor	11	0.600	9.776	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
22	DAB2IP	suppressor	5	0.700	1.667	C2 (PF00168, IPR000008, SM00239): C2 domain PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
23	DAPK1	suppressor	5	0.667	1.667	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
24	DAXX	oncoprotein	8	0.619	4.133	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
25	EGFR	oncoprotein	27	0.274	149.546	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26	ELAVL1	oncoprotein	16	0.257	56.060	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27	EZR	protein found in more fusions	16	0.705	14.182	DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
28	FADD	suppressor	24	0.435	82.595	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
29	FANCD2	oncoprotein	4	0.500	1.567	FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
30	FAS	suppressor	26	0.360	132.999	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
31	FASLG	interactor	17	0.588	34.552	PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1
32	FYN	oncoprotein	17	0.383	38.554	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
33	GRB2	oncoprotein	23	0.277	125.362	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
34	GYS2	interactor	2	1.000	0	Glycogen_syn (PF05693, IPR008631): Glycogen synthase
35	HNRNPD	oncoprotein	9	0.321	15.500	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
36	HRG	suppressor	1	0	0	Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
37	HSPA8	oncoprotein	11	0.364	28.419	HSP70 (PF00012, IPR013126): Hsp70 protein
38	IKBKB	protein found in more fusions	23	0.424	69.523	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
39	IKBKG	interactor	31	0.363	143.757	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40	JAK1	oncoprotein	5	0.833	0.333	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
41	JAK2	oncoprotein	11	0.600	7.800	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
42	KHDRBS1	protein found in more fusions	11	0.489	12.755	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
43	LTA	oncoprotein	3	0.667	1.000	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
44	LTB	oncoprotein	2	1.000	0	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
45	MADD	suppressor	1	0	0	DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus uDENN (PF03456, IPR005113, SM00800): uDENN domain
46	MAGEH1	interactor	1	0	0	MAGE (PF01454, IPR002190): MAGE family
47	MAP3K7	oncoprotein	17	0.533	21.743	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
48	MAPK1	oncoprotein	6	0.400	4.583	Pkinase (PF00069, IPR000719): Protein kinase domain
49	MAPK8	oncoprotein	19	0.549	44.314	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
50	MSN	oncoprotein	14	0.872	4.650	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
51	MUC1	oncoprotein	8	0.607	5.400	SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter
52	MYOC	interactor	2	0	0	IncA (PF04156, IPR007285): IncA protein OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
53	NOL3	oncoprotein	7	0.800	1.352	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
54	NSMAF	interactor	1	0	0	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain GRAM (PF02893, IPR004182, SM00568): GRAM domain NABP (PF07990, IPR012940): Nucleic acid binding protein NABP WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
55	OPTN	protein found in more fusions	8	0.571	4.841	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
56	PHAX	interactor	1	0	0	RNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
57	PIK3CA	oncoprotein	7	0.524	6.817	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
58	PIK3R1	oncoprotein	16	0.505	27.995	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
59	PIP4K2B	protein found in more fusions	2	0	0	PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
60	PPP1CA	suppressor	9	0.361	18.352	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
61	PRDX3	interactor	5	0.500	1.500	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
62	PRKCB	suppressor	9	0.571	5.502	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
63	PRKCD	suppressor	9	0.429	8.386	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
64	PSMD2	oncoprotein	6	0.400	7.333	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
65	RHOA	suppressor	16	0.650	21.512	Ras (PF00071, IPR001806, SM00173): Ras family
66	RIPK1	protein found in more fusions	33	0.347	165.174	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
67	RIPK2	interactor	14	0.756	5.035	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
68	RIPK3	interactor	8	0.750	2.917	Pkinase (PF00069, IPR000719): Protein kinase domain TrbM (PF07424, IPR009989): TrbM MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c RHIM (PF12721, IPR025735): RIP homotypic interaction motif
69	RNF31	interactor	14	0.692	8.111	Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain PUB (PF09409, IPR018997): PUB domain TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
70	RNF8	suppressor	4	0.667	0.200	FHA (PF00498, IPR000253, SM00240): FHA domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
71	SGTA	interactor	2	1.000	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
72	SH3KBP1	protein found in more fusions	16	0.438	29.620	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
73	SHARPIN	interactor	10	0.806	1.590	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
74	SOS1	oncoprotein	8	0.786	2.000	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
75	SRC	oncoprotein	21	0.400	53.183	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
76	STAMBP	interactor	3	0.667	0.400	USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
77	STAT1	suppressor	11	0.289	21.336	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
78	SUMO1	interactor	8	0.524	6.090	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
79	SYK	suppressor	11	0.600	8.314	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
80	SYNCRIP	interactor	6	0.533	5.500	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
81	TNF	oncoprotein	24	0.391	80.994	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
82	TNFAIP3	suppressor	18	0.647	14.844	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
83	TNFRSF10B	suppressor	18	0.621	23.088	Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
84	TNFRSF1B	oncoprotein	16	0.362	54.825	TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
85	TNFSF13	interactor	4	0.667	0.667	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
86	TRADD	interactor	22	0.381	66.565	Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat
87	TRAF1	oncoprotein	21	0.568	27.526	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
88	TRAF2	interactor	33	0.385	129.002	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
89	TRAF3	oncoprotein	18	0.412	39.864	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29
90	TRAF6	protein found in more fusions	26	0.367	99.830	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
91	TRAP1	oncoprotein	1	0	0	HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
92	TRPC1	interactor	8	0.476	8.667	Ion_trans (PF00520, IPR005821): Ion transport protein TRP_2 (PF08344, IPR013555): Transient receptor ion channel II Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
93	TRPC4	protein found in more fusions	5	1.000	0	Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) IncA (PF04156, IPR007285): IncA protein Ion_trans (PF00520, IPR005821): Ion transport protein TRP_2 (PF08344, IPR013555): Transient receptor ion channel II Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
94	TRPC4AP	interactor	10	0.556	16.882	Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
95	TRPC5	interactor	4	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) Ion_trans (PF00520, IPR005821): Ion transport protein TRP_2 (PF08344, IPR013555): Transient receptor ion channel II Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
96	UBE2I	interactor	15	0.319	39.180	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
97	UBQLN1	protein found in more fusions	5	0.500	1.786	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
98	UCHL1	suppressor	6	0.533	3.309	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
99	USP2	interactor	9	0.750	1.863	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
100	USP4	oncoprotein	7	0.933	0.118	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
101	VWA9	interactor	1	0	0	VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain

B a c k t o T o p ⇑

List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	TNFRSF1A	parental protein	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region	AU310151

B a c k t o T o p ⇑

Fusion ID: Protein names:	TNFRSF1A
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Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors (in fusions)