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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TNFAIP1 (from a repository: Fri Nov 18 04:02:45 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins9 (19.57 %)
The number (and %) of the tumor suppressors4 (8.70 %)
Total number of binary PPIs (saturation %)154 (14.88 %)
The number (and %) of affected PPIs46 (29.87 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.957
Assortativity coefficient-0.3843
The network average Clustering coefficient0.565
The number (and %) of a zero Clustering coefficients9 (19.57 %)
The number (and %) of a zero Betweenness Centrality21 (45.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TNFAIP1 All fusions
Proteins found in more fusions KDM1A (see 2 fusions); TNFAIP1 (see 1 fusions); CUL3 (see 1 fusions); PCNA (see 1 fusions); BAG3 (see 4 fusions); SUV39H1 (see 1 fusions); FAF1 (see 2 fusions); ZDHHC17 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TNFAIP1parental protein460.0931539.852BTB_2 (PF02214, IPR003131): BTB/POZ domain
2 ANLNoncoprotein81.0000Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
3 ARMC7interactor21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
4 ARNToncoprotein100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 BAG3oncoprotein70.4007.500BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 CAPN7interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
7 CAPZA2interactor90.8612.333F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
8 CARD9interactor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
9 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
10 CSNK2Binteractor70.4006.952CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
11 CUL3protein found in more fusions180.25784.719Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12 DAPP1interactor100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
13 DCUN1D1interactor50.7001.400Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
14 DVL2interactor40.6670.500DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
15 EMC2interactor100TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
16 EPM2AIP1interactor200Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
17 EXOSC5interactor40.5002.067RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
18 FAF1protein found in more fusions80.7144.400UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
19 FLNCinteractor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
20 HAT1interactor21.0000Hat1_N (PF10394, IPR019467): Histone acetyl transferase HAT1 N-terminus
Acetyltransf_7 (PF13508, IPR000182): Acetyltransferase (GNAT) domain
Acetyltransf_10 (PF13673, IPR000182): Acetyltransferase (GNAT) domain
21 HSPA1Linteractor60.4675.967HSP70 (PF00012, IPR013126): Hsp70 protein
22 KCTD10interactor110.45522.700BTB_2 (PF02214, IPR003131): BTB/POZ domain
23 KCTD13interactor120.38227.400BTB_2 (PF02214, IPR003131): BTB/POZ domain
24 KDM1Aprotein found in more fusions31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
25 LIMA1suppressor110.63612.752LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
26 MYH9suppressor81.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
27 MYO18Ainteractor100.7565.019Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
28 NXF1interactor100.38914.800NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
29 PCNAoncoprotein51.0000PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
30 POLR1Cinteractor21.0000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
31 PPP1CBinteractor110.58217.567Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 PSMA1interactor40.6670.667Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
33 RHOAsuppressor50.6002.133Ras (PF00071, IPR001806, SM00173): Ras family
34 RHOBsuppressor100Ras (PF00071, IPR001806, SM00173): Ras family
35 RIN3interactor21.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
SH2 (PF00017, IPR000980, SM00252): SH2 domain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
36 STK16interactor40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
37 SUV39H1protein found in more fusions40.6671.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
38 SVILinteractor81.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
39 SYNPOinteractor100.7338.619Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
40 TEPSINinteractor21.0000ENTH (PF01417, IPR001026, SM00273): ENTH domain
41 TUBB4Ainteractor30.6670.400Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
42 UBXN1interactor90.5369.019Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
43 UBXN7interactor60.9330.400UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
44 XPO1interactor80.28617.167CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
45 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
46 ZMYND19interactor21.0000zf-MYND (PF01753, IPR002893): MYND finger
HNH_3 (PF13392, IPR003615): HNH endonuclease

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