Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins TNF (from a repository: Fri Nov 11 23:00:55 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 97 The number (and %) of the onco-proteins 28 (28.87 %) The number (and %) of the tumor suppressors 13 (13.40 %) Total number of binary PPIs (saturation %) 380 (8.16 %) The number (and %) of affected PPIs 97 (25.53 %) The number of possible different fusions 19 PPI diameter 2 PPI radius 1 The average degree of PPI 6.969 Assortativity coefficient -0.4533 The network average Clustering coefficient 0.449 The number (and %) of a zero Clustering coefficients 32 (32.99 %) The number (and %) of a zero Betweenness Centrality 48 (49.48 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TNF	All fusions : AI880081;
Proteins found in more fusions	OPTN (see 1 fusions); HNRNPD (see 1 fusions); TAB2 (see 1 fusions); TNF (see 1 fusions); POU2F1 (see 1 fusions); RIPK1 (see 1 fusions); LYN (see 1 fusions); HSPB1 (see 3 fusions); MAP3K7 (see 7 fusions); IKBKB (see 2 fusions); UBC (see 1 fusions); RAC1 (see 1 fusions); FYN (see 1 fusions); CLU (see 5 fusions); UBE2N (see 1 fusions); B4GALT1 (see 2 fusions); LAMP2 (see 1 fusions); TNFRSF1A (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	TNF	parental protein	97	0.053	7513.557	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
2	ABCB6	interactor	1	0	0	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter MTABC_N (PF16185, IPR032410): Mitochondrial ABC-transporter N-terminal five TM region
3	ACP2	interactor	2	1.000	0	His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
4	AGO2	interactor	5	0.700	0.872	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
5	B4GALT1	protein found in more fusions	3	1.000	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
6	B4GALT5	oncoprotein	2	1.000	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
7	BDH1	interactor	1	0	0	adh_short (PF00106, IPR002198): short chain dehydrogenase DUF1776 (PF08643, IPR013952): Fungal family of unknown function (DUF1776)
8	BGN	oncoprotein	2	1.000	0	LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
9	BIRC2	oncoprotein	13	0.606	12.802	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10	BTRC	oncoprotein	15	0.407	33.029	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
11	CAPNS1	interactor	2	1.000	0	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12	CASP8	suppressor	14	0.628	11.676	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
13	CAV1	suppressor	9	0.528	12.252	Caveolin (PF01146, IPR001612): Caveolin
14	CDC42	oncoprotein	7	0.667	2.483	Ras (PF00071, IPR001806, SM00173): Ras family
15	CDYL	interactor	2	1.000	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
16	CELSR2	interactor	1	0	0	7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family) EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif Laminin_G_2 (PF02210, IPR001791): Laminin G domain Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF Cadherin_3 (PF16184): Cadherin-like GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
17	CHUK	suppressor	22	0.414	69.264	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
18	CLU	suppressor	6	0.800	0.582	Clusterin (PF01093, IPR000753): Clusterin
19	CPD	interactor	2	1.000	0	Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
20	CYLD	suppressor	11	0.673	5.988	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
21	DAG1	interactor	4	0.667	1.167	DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
22	DCN	suppressor	1	0	0	LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
23	DDX19B	interactor	3	0.667	0.667	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
24	ELAVL1	oncoprotein	22	0.190	148.510	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
25	FADD	suppressor	10	0.733	5.072	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
26	FAS	suppressor	11	0.511	18.300	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
27	FBXW11	interactor	7	0.733	1.586	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
28	FLT4	interactor	2	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
29	FREM2	interactor	1	0	0	Calx-beta (PF03160, IPR003644, SM00237): Calx-beta domain Cadherin_3 (PF16184): Cadherin-like
30	FYN	oncoprotein	7	0.667	3.067	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31	GK	interactor	1	0	0	FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain FGGY_N (PF00370, IPR018484): FGGY family of carbohydrate kinases, N-terminal domain
32	GLS	interactor	1	0	0	Glutaminase (PF04960, IPR015868): Glutaminase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
33	GUF1	interactor	1	0	0	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 LepA_C (PF06421, IPR013842): GTP-binding protein LepA C-terminus SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit RF3_C (PF16658, IPR032090): Class II release factor RF3, C-terminal domain
34	HNRNPA1	interactor	11	0.444	16.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
35	HNRNPD	oncoprotein	9	0.393	13.286	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
36	HS6ST2	interactor	1	0	0	Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family Clr2 (PF10383, IPR018839): Transcription-silencing protein Clr2
37	HSP90B3P	interactor	1	0	0	NA
38	HSPA12A	interactor	1	0	0	HSP70 (PF00012, IPR013126): Hsp70 protein
39	HSPA13	interactor	1	0	0	HSP70 (PF00012, IPR013126): Hsp70 protein
40	HSPB1	oncoprotein	12	0.436	16.373	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
41	HSPB2	interactor	5	0.500	2.667	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
42	ICOS	interactor	2	0	0	V-set_2 (PF15910, IPR013106): ICOS V-set domain
43	IKBKB	protein found in more fusions	16	0.581	16.787	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
44	IKBKG	interactor	27	0.345	139.549	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
45	INTS5	interactor	1	0	0	INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
46	ITIH2	interactor	1	0	0	ITI_HC_C (PF06668, IPR010600): Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
47	LAMP2	protein found in more fusions	4	1.000	0	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
48	LNPEP	oncoprotein	1	0	0	Peptidase_M1 (PF01433, IPR014782): Peptidase family M1 ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain Dynactin (PF12455, IPR022157): Dynein associated protein
49	LYN	oncoprotein	5	0.667	1.286	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50	MAP2K2	interactor	2	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
51	MAP3K7	oncoprotein	14	0.615	11.177	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
52	MTX3	interactor	1	0	0	Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
53	NCLN	interactor	1	0	0	Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
54	NCR3LG1	interactor	1	0	0	Gag_MA (PF01140, IPR000840): Matrix protein (MA), p15 V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
55	NEK7	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
56	NEO1	interactor	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
57	NFKBIA	oncoprotein	11	0.491	15.386	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
58	NRP1	interactor	2	1.000	0	CUB (PF00431, IPR000859, SM00042): CUB domain MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain DUF3481 (PF11980, IPR022579): C-terminal domain of neuropilin glycoprotein
59	OPTN	protein found in more fusions	11	0.467	13.123	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
60	OTULIN	interactor	6	0.667	1.836	Peptidase_C101 (PF16218, IPR023235): Peptidase family C101
61	PCDH7	interactor	1	0	0	Cadherin_2 (PF08266, IPR013164): Cadherin-like Protocadherin (PF08374, IPR013585): Protocadherin Cadherin (PF00028, IPR002126, SM00112): Cadherin domain SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG Cadherin_3 (PF16184): Cadherin-like
62	PLXNA2	interactor	1	0	0	IncA (PF04156, IPR007285): IncA protein Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain
63	POU2F1	protein found in more fusions	2	0	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
64	PSMD9	interactor	4	1.000	0	Remorin_C (PF03763, IPR005516): Remorin, C-terminal region DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046) PDZ_2 (PF13180, IPR001478): PDZ domain
65	PTPRS	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase Ig_3 (PF13927): Immunoglobulin domain
66	RAB18	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
67	RAB5A	oncoprotein	4	0.667	1.667	Ras (PF00071, IPR001806, SM00173): Ras family
68	RAC1	oncoprotein	6	0.500	2.567	Ras (PF00071, IPR001806, SM00173): Ras family
69	RALBP1	interactor	6	0.533	3.082	DDHD (PF02862, IPR004177, SM01127): DDHD domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SlyX (PF04102, IPR007236): SlyX Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505) Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
70	RBCK1	interactor	12	0.636	7.748	GAGA (PF09237, IPR015318): GAGA factor IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
71	RC3H1	interactor	2	1.000	0	PaaA_PaaC (PF05138, IPR007814): Phenylacetic acid catabolic protein zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
72	RHEB	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
73	RIPK1	protein found in more fusions	22	0.505	42.774	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
74	RNF31	interactor	13	0.727	6.375	Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain PUB (PF09409, IPR018997): PUB domain TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
75	RNF8	suppressor	5	0.667	0.468	FHA (PF00498, IPR000253, SM00240): FHA domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
76	SEC61A1	interactor	2	1.000	0	DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430) SecY (PF00344, IPR002208): SecY translocase Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
77	SEMA4C	interactor	1	0	0	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049) PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
78	SFXN5	interactor	2	1.000	0	Mtc (PF03820, IPR004686): Tricarboxylate carrier
79	SHARPIN	interactor	11	0.667	5.872	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
80	TAB1	interactor	7	0.857	0.983	PP2C (PF00481, IPR001932): Protein phosphatase 2C
81	TAB2	oncoprotein	11	0.778	3.031	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
82	TAMM41	interactor	2	0	0	Mmp37 (PF09139, IPR015222): Mitochondrial matrix Mmp37
83	TBK1	interactor	11	0.489	10.837	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
84	TM2D3	interactor	1	0	0	TM2 (PF05154, IPR007829): TM2 domain
85	TMEM259	interactor	1	0	0	Membralin (PF09746, IPR019144): Tumour-associated protein
86	TNFAIP3	suppressor	20	0.485	41.441	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
87	TNFRSF1A	oncoprotein	24	0.391	86.845	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
88	TNFRSF1B	oncoprotein	8	0.905	0.733	TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
89	TNFSF9	suppressor	1	0	0	Albumin_I (PF08027, IPR012512): Albumin I chain b TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
90	TNIP1	interactor	8	0.667	3.027	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
91	TRADD	interactor	12	0.691	6.855	Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat
92	TRAF2	interactor	28	0.333	152.745	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
93	UBC	protein found in more fusions	25	0.272	142.400	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
94	UBE2N	protein found in more fusions	12	0.509	16.756	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
95	UFL1	suppressor	1	0	0	CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone Helicase_RecD (PF05127, IPR007807): Helicase DUF2042 (PF09743, IPR018611): Uncharacterized conserved protein (DUF2042) UBN_AB (PF14075, IPR026947): Ubinuclein conserved middle domain IL31 (PF15209, IPR027987): Interleukin 31
96	YWHAQ	interactor	7	0.381	10.452	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
97	ZFP36	suppressor	3	0.667	0.667	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

B a c k    t o    T o p ⇑