Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TMCC2 (from a repository: Thu Nov 10 14:59:26 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins5 (20.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)64 (21.33 %)
The number (and %) of affected PPIs25 (39.06 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.080
Assortativity coefficient-0.0785
The network average Clustering coefficient0.588
The number (and %) of a zero Clustering coefficients4 (16.00 %)
The number (and %) of a zero Betweenness Centrality12 (48.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TMCC2 All fusions
: BM466472; BC053876; DA808828;
Proteins found in more fusions APP (see 4 fusions); TMCC2 (see 3 fusions); KAT5 (see 3 fusions); AES (see 3 fusions); AMOTL2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TMCC2parental protein250.098431.333Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
2 AESprotein found in more fusions90.28618.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 AMOTL2protein found in more fusions41.0000HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
4 APPprotein found in more fusions100.25025.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CCDC33interactor60.4007.667C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
6 CDR2interactor50.6672.000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
7 CFAP206interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
8 DIP2Ainteractor30.6670.500AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
9 DPY30interactor200Dpy-30 (PF05186, IPR007858): Dpy-30 motif
10 EIF4E2interactor50.5004.500IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
11 FAM161Ainteractor40.6671.000YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
12 FAM74A4interactor100NA
13 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
14 FBF1interactor40.6671.167DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
15 HGSinteractor40.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
16 HSPD1oncoprotein21.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 IQUBinteractor200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3664 (PF12406, IPR022131): Surface protein
Stc1 (PF12898, IPR024630): Stc1 domain
DUF4041 (PF13250, IPR025280): Domain of unknown function (DUF4041)
18 KAT5oncoprotein31.0000MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
19 PRPF31interactor50.5003.000Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
20 RHOXF2interactor50.6671.167DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
21 WT1-ASinteractor100NA
22 ZNF250interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
23 ZNF417interactor21.0000A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
24 ZNF581interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
25 ZNF587interactor30.6671.000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k    t o    T o p ⇑